Results 101 to 110 of about 4,226,166 (391)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Population and Reproductive Health in National Adaptation Programs of Action [PDF]

, 2009
This paper reviews 41 National Adaptation Programmes of Action (NAPAs) submitted by Least Developed Countries (LDCs) to the United Nations Framework Convention on Climate Change (UNFCCC), and identifies the range of interventions included in countries ...
Clive Mutunga, Karen Hardee
core  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Digital communication between mothers and community health workers to support neonatal health (CHV-NEO): study protocol for a randomized controlled trial

Trials
Background Provision of essential newborn care at home, rapid identification of illness, and care-seeking by caregivers can prevent neonatal mortality.
Keshet Ronen, Lincoln C. Pothan, Violet Apondi, Felix A. Otieno, Daniel Mwakanema, Felix O. Otieno, Lusi Osborn, Julia C. Dettinger, Priyanka Shrestha, Helena Manguerra, Ferdinand Mukumbang, Millicent Masinde, Evelyn Waweru, Mercy Amulele, Christine Were, Beatrice Wasunna, Grace John-Stewart, Bryan Weiner, Arianna Rubin Means, Barbra A. Richardson, Anna B. Hedstrom, Jennifer A. Unger, John Kinuthia   +22 more
doaj   +1 more source

Health Care for Veterans: Answers to Frequently Asked Questions [PDF]

, 2015
The Veterans Health Administration (VHA), within the Department of Veterans Affairs (VA), operates the nation’s largest integrated direct health care delivery system, provides care to approximately 6.6 million unique veteran patients, and employs more ...
Panangala, Sidath Viranga
core   +4 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Attitudes toward a future norovirus vaccine among members of an integrated healthcare delivery system in Portland, Oregon, 2016-2017

Human Vaccines & Immunotherapeutics
With recent advances in U.S. clinical trials for norovirus vaccines, it is an opportune time to examine what is known about the public receptivity to this novel vaccine. From October 2016–September 2017, we surveyed Kaiser Permanente Northwest members in
Holly C. Groom, Mark Schmidt, Laura E. Calderwood, Sara A. Mirza, Claire Mattison, Suzanne Salas, Judy Donald, Allison L. Naleway   +7 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Microbial ligand costimulation drives neutrophilic steroid-refractory asthma [PDF]

, 2015
Funding: The authors thank the Wellcome Trust (102705) and the Universities of Aberdeen and Cape Town for funding. This research was also supported, in part, by National Institutes of Health GM53522 and GM083016 to DLW. KF and BNL are funded by the Fonds
AT Nathan, B Schaub, BA Fallert, Bart N. Lambrecht, Bernhard Ryffel, Beth A. Fallert Junecko, BN Lambrecht, BN Lambrecht, BN Lambrecht, BR O'Driscoll, C Braun-Fahrlander, CE Reed, David L. Williams, DC Newcomb, EC Cates, F Gerosa, F Kirstein, Frank Brombacher, Frank Kirstein, G Trinchieri, GD Brown, Gordon D. Brown, GP Anderson, Graeme Murray, H Hammad, HE Ensley, HS Goodridge, I Agache, J Chakir, J Douwes, J Thorn, J Zhao, Jay K. Kolls, JB Allard, JH Bonlokke, JL Simpson, Kaat Fierens, KM Dennehy, KM Dennehy, Kong Chen, L Dong, L McKinley, LG Gregory, LK Fogli, LM Lilly, M Kudo, M Laan, M Plantinga, M Rosas, N Pearce, NN Jarjour, PC Porter, Pierre Redelinghuys, PJ Barnes, R Rylander, RA Drummond, RA Martin, RA Mintz-Cole, RA Mintz-Cole, Rebecca A. Drummond, RH Wilson, S Ano, S Saad-El-Din Bessa, Sabelo Hadebe, Sara Sajaniemi, SC Cheng, SC Eisenbarth, Simon Vautier, Todd A. Reinhart, W Eder, WC Moore, ZZ Pan   +71 more
core   +8 more sources

Zoonotic Disease Programs for Enhancing Global Health Security

Emerging Infectious Diseases, 2017
Most infectious diseases that recently emerged in humans originated in animals. Besides close contact between animals and humans, other factors probably contribute to the cross-species transmission of infectious diseases.
E. Belay, James C Kile, A. Hall, C. Barton-Behravesh, M. Parsons, S. Salyer, H. Walke   +6 more
semanticscholar   +1 more source