Results 101 to 110 of about 2,764,193 (353)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Population, Heath and Women [PDF]

There are a number of issues regarding women’s health, women’s reproductive behavior, fertility impact of reproductive health programs and the effect of gender roles and expectations in these factors.
Abad, Henedina Razon
core   +2 more sources

Factors associated with mortality in persons co-infected with tuberculosis and HIV in Suriname: a retrospective cohort study

Revista Panamericana de Salud Pública, 2019
Objective. To identify socio-demographic and clinical factors associated with mortality among persons with tuberculosis (TB) and TB/HIV co-infection in Suriname. Methods.
Deborah Stijnberg, Eric Commiesie, Diana Marín, Ward Schrooten, Freddy Perez, Mauro Sanchez   +5 more
doaj   +1 more source

Do National Health Insurance Programs for the Poor Improve the Relative Health Outcomes of the Poor? Evidence from India

, 2022
Preshit Ambade, Tauhidur Rahman
openalex   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Contextual inequalities in specialized dental public health care in Brazil

Brazilian Oral Research
The present study aimed to investigate the contextual inequalities of specialized public dental care (SPDC) in Brazil. The outcome was the trajectory of dental specialized production in municipalities with SPDC (from 2015 to 2017) obtained by group-based
Ana Luiza Cardoso PIRES, Francine dos Santos COSTA, Otávio Pereira D’ÁVILA, Rodrigo Varella de CARVALHO, Marcus Cristian Muniz CONDE, Marcos Britto CORREA, Flávio Fernando DEMARCO, Luiz Alexandre CHISINI   +7 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Ideational factors associated with appropriate care-seeking for fever among caregivers of children under five years of age: a multi-country analysis in sub-Saharan Africa

Malaria Journal
Background With an estimated 247 million cases and 619,000 deaths reported worldwide in 2021, malaria remains a major cause of morbidity and mortality. The World Health Organization (WHO) Africa region accounts for most cases and deaths.
Albert Casella, Michael Bride, Gabrielle C. Hunter, Michael Toso, Grace N. Awantang, Alain K. Koffi, Jayme Hughes, Thérèse Bleu, Bolanle Olapeju, Abdul Dosso, Florence Mpata, Eric Sompwe Mukomena, Stella Babalola   +12 more
doaj   +1 more source

Community acceptance and implementation of HIV prevention interventions for injection drug users [PDF]

, 2002
In 1997, the National Institutes of Health (NIH) reviewed evidence of the effectiveness of HIV prevention programs for injection drug users (IDUs) and recommended that three types ofinterventions be implemented to prevent transmission of HIV among IDUs ...
Brian R. Edlin, Courtney McKnight, Don C. Des Jarlais, Karen Vernon, Moher Downing, Nina Mulia, Thomas H. Riess   +6 more
core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source