Results 71 to 80 of about 4,181,730 (416)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
BMC Geriatrics, 2023 Background Cognitive decline is common in older adults and imposes a burden on public health. Especially for older adults, hospitalization can be related to decreased physical fitness.
Dougho Park +2 more
doaj +1 more source
Data fusion for predicting long-term program impacts [PDF]
arXiv, 2022 Policymakers often require information on programs' long-term impacts that is not available when decisions are made. We demonstrate how data fusion methods may be used address the problem of missing final outcomes and predict long-run impacts of interventions before the requisite data are available.
arxiv
National Institute of Child Health and Human Development
Definitions, 2020 Description: A national institute that investigates human development throughout the entire life process, focusing on understanding developmental disabilities, including intellectual and developmental disabilities, and illuminating important events that ...
E. K. Shriver
semanticscholar +1 more source
Improving Teen Engagement in Buffalo and Erie County [PDF]
, 2018 Erie County offers many opportunities for teen engagement through afterschool programs, summer jobs programs, and internships. National research reveals many benefits from these programs, such as improved academic achievement, better health outcomes, and
Bramhall, Emily +2 more
core +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Trans-national scale-up of services in global health. [PDF]
PLoS ONE, 2014 BACKGROUND:Scaling up innovative healthcare programs offers a means to improve access, quality, and health equity across multiple health areas. Despite large numbers of promising projects, little is known about successful efforts to scale up.
Ilan Shahin +9 more
doaj +1 more source
An Open Data and Geo-based Information Systems [PDF]
arXiv, 2022 Barangay is the smallest type of government in the Philippines, and it is driven and represented by its barangay authorities. The barangay officials are accountable for keeping the records of citizens health and crime incidents. It also the first-hand source of information of the national government to develop government programs, community services ...
arxiv
American Journal of Public Health, 2015 OBJECTIVES We tested whether the immigrant health advantage applies to non-Hispanic Black immigrants and examined whether nativity-based differences in allostatic load exist among non-Hispanic Blacks.
Lauren A. Doamekpor +1 more
semanticscholar +1 more source
County and City Health Departments: The Need for Sustainable Funding and the Potential Effect of Health Care Reform on Their Operations [PDF]
, 2009 Outlines the role of local health departments, the impact of funding cuts on staff, programs, and services, and the implications for public health.
Jack A. Meyer, Lori Weiselberg
core