Results 101 to 110 of about 1,618,479 (311)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Examining the effects of national initiatives to improve the physical health of people with psychosis in England: secondary analysis of data from the National Clinical Audit of Psychosis. [PDF]
BJPsych Bull, 2022 Williams R +8 more
europepmc +1 more source
Research Review: Whole school approaches to sustainability: An international review of whole-school sustainability programs [PDF]
, 2006 Education for sustainability is an emerging concept encompassing "a new vision of education that seeks to empower people of all ages to assume responsibility for creating a sustainable future" (UNESCO, 2002).
Davis, Julie M.
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
RORα controls hepatic lipid homeostasis via negative regulation of PPARγ transcriptional network
Nature Communications, 2017 Hepatic steatosis development may result from dysregulation of lipid metabolism, which is finely tuned by several transcription factors including the PPAR family. Here Kim et al. show that the nuclear receptor RORα inhibits PPARγ-mediated transcriptional
Kyeongkyu Kim +16 more
doaj +1 more source
Handwashing with Soap -- Two Paths to National-Scale Programs Lessons from the Field: Vietnam and Indonesia [PDF]
, 2011 This paper describes two Southeast Asian programs that are making handwashing a feature of everyday lives on a national scale. The program in Vietnam has concentrated on first gaining an understanding on how people actually behave and then determing how ...
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
BMC Genetics, 2018 Background Like glucose-6-phosphate dehydrogenase (G6PD) deficient hemizygous males and homozygous females, heterozygous females could also manifest hemolytic crisis, neonatal hyperbilirubinemia or kernicterus upon exposure to oxidative stress induced by
Md Tarikul Islam +23 more
doaj +1 more source
Resources and Tools:A Step-by-Step Methodological Guide for Costing HIV/AIDS Activities [PDF]
, 2001 Many developing countries have recognized the need for comprehensive national reforms and comprehensive prevention, treatment, and care and support initiatives to reduce future transmission of and to meet the growing demand for HIV/AIDS services.
Huff-Rousselle, Maggie +1 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source