Results 171 to 180 of about 59,037 (259)

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

N-terminal proBNP adds prognostic value to high-sensitivity cardiac troponin I in elective thoracic surgery: an observational cohort study. [PDF]

BMJ Open
Alonso M, Popova E, De Miguel M, García-Osuna Á, Gonzalez-Tallada A, Ordoñez-Llanos J, Jauregui A, Trujillo JC, Martin Grande A, Martínez-Téllez E, Parera A, Planas G, Trujillo L, Butron D, Solà-Roca J, De Nadal M.   +15 more
europepmc   +1 more source

Determinants of Abnormal Pulmonary Vasodilatory Response With Exercise in HFpEF: Pulmonary Vascular‐Left Atrial Axis Abnormalities

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Compared to traditional cardiometabolic comorbidities, COPD and atrial fibrillation are uniquely linked to pulmonary vascular remodeling in HFpEF. The impact of these two comorbidities on pulmonary vascular‐left atrial axis is highlighted by the shared biventricular morphology among HFpEF subgroups.
Mariana Garcia‐Arango, Angela Kristo, Ahmed El Shaer, Yimin Chen, Aditya Sahai, Anas Abed, Wanxin Tu, Soham Ghosh, Babak Tehrani, Shannon Heffernan, Amir Esmaeeli, Tashfeen Javaid, Ran Tao, Naga Dharmavaram, James Runo, Alejandro Roldán‐Alzate, Adam D. Gepner, Matthew Kalscheur, Colleen M. Witzenburg, Ryan J. Tedford, Farhan Raza   +20 more
wiley   +1 more source

Invasive Confirmation of Microvascular Recovery Parallel to Left Ventricular Functional Restoration. [PDF]

JACC Case Rep
Toya T, Kondo T, Sekine O, Aoyama M, Sumida N, Nishimura T, Miyazaki Y, Inagawa K, Sakamoto M, Momiyama Y.   +9 more
europepmc   +1 more source

Vector‐based comparison as a novel framework for assessing multi‐endpoint clinical trials: Applications to actual data

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Multi‐endpoint clinical trials face long‐standing statistical challenges. Vector‐based comparison (VBC) decomposes endpoints into orthogonal components. Applied to five clinical trials, it reduced confidence‐interval widths by about 50%, indicating higher statistical power, without altering the clinical meaning of endpoints.
Maria Kokkali, Vangelis D. Karalis
wiley   +1 more source

Bioelectrical impedance analysis and physical function improved risk prediction for cardiac dysfunction in hemodialysis patients. [PDF]

Front Physiol
Zhang W, Yao L, Zhu Q, Lu J, Liu Q, Ding W.   +5 more
europepmc   +1 more source

Mesenchymal stem cell‐derived exosomes for cardiac repair: Challenges, standardization gaps and a realistic path to clinical translation

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Mesenchymal stem cell‐derived exosomes (MSC‐sEVs) show preclinical promise for cardiac repair via anti‐inflammatory, anti‐apoptotic, pro‐angiogenic and anti‐fibrotic effects. However, translational hurdles remain, including non‐standardized isolation, unvalidated potency assays, incomplete GMP manufacturing, and lack of completed Phase II/III trials ...
Sakhavat Abolhasani, Yasin Ahmadi, Amin Jalizih   +2 more
wiley   +1 more source

Mac-2 binding protein glycosylation isomer contributes to identify advanced Fontan-associated liver disease: A retrospective cohort study. [PDF]

Medicine (Baltimore)
Kitsugi K, Hosoda Y, Murohisa G, Yoshizawa Y, Kimata M, Kobayashi Y, Unno S, Yamada Y, Takayanagi T, Kawata K.   +9 more
europepmc   +1 more source

Extreme Heterophilic Antibody Interference in BNP Immunoassay: A Case Report and Systematic Investigation Protocol

Journal of Clinical Laboratory Analysis, Volume 40, Issue 15, August 2026.
A 53 year‐old male with type 2 diabetes presented extremely elevated BNP (> 4000 pg/mL) but normal NT‐proBNP and cardiac function. Systematic verification confirmed severe heterophilic antibody (HAMA) interference in the BNP chemiluminescence immunoassay.
Huicong Yang, Yuanhai Zheng, Zhenhua Zeng, Haimin Gao, Jinzhi Wu, Ayang Wu, Jie Lin   +6 more
wiley   +1 more source

Screening for HFpEF in pacemaker patients: Study design and protocol of the PM-HFpEF study. [PDF]

PLoS One
Santos E, Teixeira R, Almeida J, Fonseca P, Oliveira M, Gonçalves H, Primo J, Diaz S, Barros A, Vilela E, Sampaio F, Saraiva F, Oliveira M, de Carvalho RF.   +13 more
europepmc   +1 more source