Results 1 to 10 of about 164,352 (233)

Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart

Biology, 2022
C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of
Akihiro Yasoda
doaj   +2 more sources

C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness

JCI Insight, 2020
Heart failure is often accompanied by titin-dependent myocardial stiffness. Phosphorylation of titin by cGMP-dependent protein kinase I (PKGI) increases cardiomyocyte distensibility.
Konstanze Michel, Melissa Herwig, Franziska Werner, Katarina Špiranec Spes, Marco Abeßer, Kai Schuh, Swati Dabral, Andreas Mügge, Hideo A. Baba, Boris V. Skryabin, Nazha Hamdani, Michaela Kuhn   +11 more
doaj   +2 more sources

Endothelial C-type natriuretic peptide maintains vascular homeostasis [PDF]

Journal of Clinical Investigation, 2014
PMCID: PMC4151218Wellcome Trust (084449/Z/07/Z and 078496/Z/05 ...
Adrian J. Hobbs, Amie J. Moyes, Amrita Ahluwalia, Anne-Sophie Rebstock, Brown, Carlos F. Sánchez Ferrer, Chen, Clavell, Concepción Peiró, David L. Selwood, Fang Xiao, Fernando Rivilla, Filipa Mota, Igaki, Inmaculada Villar, Krejci, Kristen J. Bubb, Ley, Lipinski, Mark J. Caulfield, Michela I. Simone, Morley, Murthy, Natalie G. Lumsden, Paul J. Gane, Pleumeekers, Potter, Raymond J. MacAllister, Rayomand S. Khambata, Reshma S. Baliga, Roberta J. Worthington, Rose, Snezana Djordjevic, Stingo, Stingo, Suga, Susana Vallejo, Trachte, Zuberi   +38 more
core   +2 more sources

C-Type Natriuretic Peptide/Natriuretic Peptide Receptor 2 Is Involved in Cell Proliferation and Testosterone Production in Mouse Leydig Cells

The World Journal of Men's Health, 2019
Purpose: This study investigated the role of natriuretic peptide receptor 2 (NPR2) on cell proliferation and testosterone secre-tion in mouse Leydig cells.Materials and Methods: Mouse testis of different postnatal stages was isolated to detect the ...
Lei Yang, Lanjie Lei, Qihan Zhao, Ying Gong, Gaopeng Guan, Shaoxin Huang   +5 more
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Dexamethasone stimulates expression of C-type Natriuretic Peptide in chondrocytes [PDF]

BMC Musculoskeletal Disorders, 2006
Background Growth of endochondral bones is regulated through the activity of cartilaginous growth plates. Disruption of the physiological patterns of chondrocyte proliferation and differentiation – such as in endocrine disorders or in many different ...
Beier Frank, Baybayan Laurie, Agoston Hanga   +2 more
doaj   +5 more sources

Role of C-type natriuretic peptide in the function of normal human sperm

Asian Journal of Andrology, 2016
C-type natriuretic peptide (CNP) is a newly discovered type of local regulatory factor that mediates its biological effects through the specific, membrane-bound natriuretic peptide receptor-B (NPR-B).
Hui Xia, Yao Chen, Ke-Jia Wu, Hu Zhao, Cheng-Liang Xiong, Dong-Hui Huang   +5 more
doaj   +2 more sources

Regulation and Function of C-Type Natriuretic Peptide (CNP) in Gonadotrope-Derived Cell Lines

Cells, 2019
C-type natriuretic peptide (CNP) is the most conserved member of the mammalian natriuretic peptide family, and is implicated in the endocrine regulation of growth, metabolism and reproduction.
Samantha M Mirczuk, Andrew J Lessey, Alice R Catterick, Rebecca M Perrett, Christopher J Scudder, Jordan E Read, Victoria J Lipscomb, Stijn J Niessen, Andrew J Childs, Craig A McArdle, Imelda M McGonnell, Robert C Fowkes   +11 more
doaj   +2 more sources

Pro-C-Type Natriuretic Peptide in Women With Angina Pectoris and No Obstructive Coronary Artery Disease [PDF]

JACC: Advances
Background: Circulating C-type natriuretic peptides (CNPs) predict adverse outcome in women presenting with ST-elevation myocardial infarction. Objectives: The purpose of this study was to determine the prognostic impact of a high proCNP concentration in
Peter D. Mark, MD, PhD, Jakob Schroder, MD, Andreas K. Jensen, MD, Timothy C.R. Prickett, PhD, Eva Prescott, MD, DMSc, Jens P. Goetze, MD, DMSc   +5 more
doaj   +1 more source

C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance The global mortality, morbidity, and healthcare costs associated with cardiometabolic disease, including obesity, diabetes, hypertension, and dyslipidemia, are substantial and represent an expanding unmet medical need.
C. Pérez-Ternero, A. Aubdool, R. Makwana, G. Sanger, R. Stimson, L. Chan, A. Moyes, A. Hobbs   +7 more
semanticscholar   +1 more source

Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide

International Journal of Molecular Sciences, 2022
The skeletal development process in the body occurs through sequential cellular and molecular processes called endochondral ossification. Endochondral ossification occurs in the growth plate where chondrocytes differentiate from resting, proliferative ...
Estera Rintz, G. Węgrzyn, T. Fujii, S. Tomatsu   +3 more
semanticscholar   +1 more source