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Physiological and Pathophysiological Effects of C-Type Natriuretic Peptide on the Heart
Biology, 2022 C-type natriuretic peptide (CNP) is the third member of the natriuretic peptide family. Unlike other members, i.e., atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are cardiac hormones secreted from the atrium and ventricle of
Akihiro Yasoda
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C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness
JCI Insight, 2020 Heart failure is often accompanied by titin-dependent myocardial stiffness. Phosphorylation of titin by cGMP-dependent protein kinase I (PKGI) increases cardiomyocyte distensibility.
Konstanze Michel +11 more
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Perspectives on C‐Type Natriuretic Peptide in Cardiometabolic Disease [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseAlthough CNP (C‐type natriuretic peptide) was first identified in brain tissue, its systemic expression and release is mainly located to the endothelial lining of the vasculature.
Jens P. Goetze +5 more
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The World Journal of Men's Health, 2019 Purpose: This study investigated the role of natriuretic peptide receptor 2 (NPR2) on cell proliferation and testosterone secre-tion in mouse Leydig cells.Materials and Methods: Mouse testis of different postnatal stages was isolated to detect the ...
Lei Yang +5 more
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Role of C-type natriuretic peptide in the function of normal human sperm
Asian Journal of Andrology, 2016 C-type natriuretic peptide (CNP) is a newly discovered type of local regulatory factor that mediates its biological effects through the specific, membrane-bound natriuretic peptide receptor-B (NPR-B).
Hui Xia +5 more
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C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance The global mortality, morbidity, and healthcare costs associated with cardiometabolic disease, including obesity, diabetes, hypertension, and dyslipidemia, are substantial and represent an expanding unmet medical need.
C. Pérez-Ternero +7 more
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Molecular Mechanism of Induction of Bone Growth by the C-Type Natriuretic Peptide
International Journal of Molecular Sciences, 2022 The skeletal development process in the body occurs through sequential cellular and molecular processes called endochondral ossification. Endochondral ossification occurs in the growth plate where chondrocytes differentiate from resting, proliferative ...
Estera Rintz +3 more
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Pathogenetic justification of sacubitril / valsartan use in respiratory-cardial comorbidity
Patologìâ, 2023 Among the comorbid conditions that significantly worsen quality of life and life expectancy are the chronic obstructive pulmonary disease and heart failure.
T. V. Ashcheulova +3 more
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Biology, 2022 The field of natriuretic peptides (NPs) as an endocrine hormone has been developing since 1979. There are three peptides in humans: atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), which bind to the guanylyl cyclase-A (GC-A ...
Tomoko Ichiki +2 more
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Molecular Mechanism of Blood Pressure Regulation through the Atrial Natriuretic Peptide
Biology, 2022 Natriuretic peptides, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), have cardioprotective effects and regulate blood pressure in mammals.
Takeshi Tokudome, Kentaro Otani
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