Results 201 to 210 of about 69,844 (264)

Ro5‐4864, a ligand of the mitochondrial translocator protein, protects against heart failure in mice via regulation of the p62‐Keap1‐Nrf2 axis

The Journal of Physiology, EarlyView.
Abstract figure legend Graphical abstract of the proposed Ro5‐4864 mechanism of action via p62‐Keap1‐Nrf2 axis in heart failure. TSPO, the 18‐kDa mitochondrial translocator protein of the outer mitochondrial membrane, can directly interact with p62 (also known as SQSTM1), which is crucial for the degradation of damaged mitochondria by autophagy ...
Daphne A. Diloretto, Phung N. Thai, Gabriela Grigorean, Veneese J. Brown, Tjien Dwyer, Nipavan Chiamvimonvat, Elena N. Dedkova, Saul Schaefer   +7 more
wiley   +1 more source

Relationship between changes in BNP, PCT, and SIGIRR levels in peripheral blood and prognosis of sepsis patients caused by abdominal infection and construction of a nomogram. [PDF]

Medicine (Baltimore)
Li S, Cui Y, Yuan J, Wang X, Ji N, Zhang J, Yao C, Zhang H.   +7 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Baseline Chronic Obstructive Pulmonary Disease Identifies a High-Risk Cardiopulmonary Phenotype in Patients with Heart Failure Undergoing SGLT2 Inhibitor Therapy. [PDF]

Diagnostics (Basel)
Jurin I, Pavlov M, Viđak M, Doder F, Patrk A, Vidaković I, Piskač Živković N.   +6 more
europepmc   +1 more source

Belimumab as a possible treatment for SLE-associated pulmonary arterial hypertension: the experience from a single centre. [PDF]

Lupus Sci Med
Wu Q, Zhou Z, Ye H, Zhang M, Sun X, Wang Q.   +5 more
europepmc   +1 more source

Identification of serum biomarkers linking myocardial fibrosis, systolic dysfunction and outcomes in patients with severe aortic stenosis. [PDF]

Cardiovasc Res
Gersch S, Ferreira JP, Leha A, Bengel P, von Haehling S, Fischer A, Beuthner BE, Zeisberg EM, Puls M, Schmidt C, Toischer K, Hasenfuß G, Schnelle M.   +12 more
europepmc   +1 more source

Association Analyses Between the <i>NPPB</i>:rs198389 Gene Polymorphism, NT-proBNP Serum Concentrations and Phenotypic Features in Patients with Heart Failure. [PDF]

Genes (Basel)
Gorący-Rosik A, Rosik J, Lewandowska K, Gorący I, Ciechanowicz A.   +4 more
europepmc   +1 more source

Cardiac Biomarker Complete Response in AL Amyloidosis: Characteristics, Cardiac Recovery, and Survival of 63 Patients. [PDF]

JACC CardioOncol
Muchtar E, Geyer S, Dispenzieri A, Grogan M, Kourelis TV, Buadi FK, Kapoor P, Dingli D, Gonsalves W, Leung N, Merlini G, Rosenthal J, Boilson B, Lyle M, Frantz JG, Hayman SR, Lacy MQ, Siddiqui M, Cook J, Abdallah N, Binder M, Zanwar S, Lin Y, Warsame R, Kyle RA, Rajkumar SV, Kumar SK, Gertz MA.   +27 more
europepmc   +1 more source