Results 61 to 70 of about 164,451 (332)

Mutations in B-type natriuretic peptide mediating receptor-A selectivity [PDF]

Libraries of monovalent display-phage expressing mutant human B-type natriuretic peptide (hBNP) were used to identify variants that preferentially bind natriuretic peptide receptor-A (NPR-A) compared to receptor-C (NPR-C).
Lowe, David G., Schoenfeld, Jill R., Tom, Jeff Y.K.   +2 more
core   +1 more source

High level of C-type natriuretic peptide induced by hyperandrogen-mediated anovulation in polycystic ovary syndrome mice.

Clinical science, 2018
Polycystic ovary syndrome (PCOS), which is characterized by hyperandrogenism, is a complex endocrinopathy that affects the fertility of 9-18% of reproductive-aged women.
Xiao Wang, Huarong Wang, Wei Liu, Zhiyuan Zhang, Yanhao Zhang, Wenqiang Zhang, Zijiang Chen, G. Xia, Chao Wang   +8 more
semanticscholar   +1 more source

Machine‐Learning‐Aided Advanced Electrochemical Biosensors

Advanced Materials, EarlyView.
Electrochemical biosensors are highly sensitive, portable, and versatile. Advanced nanomaterials enhance their performance, while machine learning (ML) improves data analysis, minimizes interference, and optimizes sensor design. Despite progress in both fields, their combined potential in diagnostics remains underexplored.
Andrei Bocan, Roozbeh Siavash Moakhar, Carolina del Real Mata, Max Petkun, Tristan De Iure‐Grimmel, Sripadh Guptha Yedire, Hamed Shieh, Arash Khorrami Jahromi, Sahar Sadat Mahshid, Sara Mahshid   +9 more
wiley   +1 more source

Natriuretic peptides and cardiovascular damage in the metabolic syndrome. Molecular mechanisms and clinical implications [PDF]

, 2010
Natriuretic peptides are endogenous antagonists of vasoconstrictor and salt- and water-retaining systems in the body's defence against blood pressure elevation and plasma volume expansion, through direct vasodilator, diuretic and natriuretic properties ...
ALONZO, ALESSANDRO, Rossi C, RUBATTU, Speranza Donatella, SAVOIA, Carmine, VOLPE, Massimo   +4 more
core   +1 more source

C-type natriuretic peptide: the heart’s guardian angel

European Heart Journal, 2019
Abstract
Yang Chen, S. Jeson Sangaralingham, John C. Burnett   +2 more
openaire   +2 more sources

Protein‐Like Polymers Targeting Keap1/Nrf2 as Therapeutics for Myocardial Infarction

Advanced Materials, EarlyView.
We describe a Keap1 targeting protein‐like polymer (PLP) which activates Nrf2, an important cytoprotective transcription factor for relieving myocardial infarction‐induced oxidative stress. This PLP increases cell survival in vitro in multiple relevant cardiac cell types and elicits pro‐reparative responses, improving cardiac function in a preclinical ...
Joshua M. Mesfin, Kendal P. Carrow, Alexander Chen, Madeline P. Hopps, JoJo J. Holm, Quincy P. Lyons, Michael B. Nguyen, Jervaughn D. Hunter, Assa Magassa, Elyse G. Wong, Kate Reimold, Sriya N. Paleti, Emily Gardner, Matthew P. Thompson, Colin G. Luo, Xiaoyu Zhang, Karen L. Christman, Nathan C. Gianneschi   +17 more
wiley   +1 more source

Combination of Amino‐Terminal Pro‐BNP, Estimated GFR, and High‐Sensitivity CRP for Predicting Cardiorenal Syndrome Type 1 in Acute Myocardial Infarction Patients

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Background Cardiorenal syndrome type 1 (CRS1) as a complication of acute myocardial infarction can lead to adverse outcomes, and a method for early detection is needed. This study investigated the individual and integrated effectiveness of amino‐terminal
De‐Qiang Zhang, Hong‐Wei Li, Hai‐Ping Chen, Qing Ma, Hui Chen, Yun‐Li Xing, Xue‐Qiao Zhao   +6 more
doaj   +1 more source

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes [PDF]

, 2013
The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of ...
A Faivre-Bauman, A Rathinavelu, AB Abou-Samra, Abir Mukherjee, AF Gilkes, AH Tashjian Jr, AM Hamad, Andrew J. Lessey, Andrew Sunters, AR Yoder, Bigboy Simbi, CA McArdle, CA McArdle, CA McArdle, Caroline P. Wheeler-Jones, Craig A. McArdle, D Fan, D Müller, DJ Hartt, DM Dickey, FN Zeytin, G Rousseau, Gary F. Baxter, GY Koh, H Chusho, H Hao, I Kishimoto, Iain R. Thompson, Imelda M. McGonnell, IR Thompson, IR Thompson, J Horvath, KN Pandey, KN Pandey, Lorna Smith, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, MA Vieira, Mark S. Roberson, MB Henesy, MJ Lopez, N Tamura, PM Hinkle, RC Fowkes, RC Fowkes, RC Fowkes, RC Fowkes, Robert C. Fowkes, S Inagaki, S Suga, SA Bayol, Samantha M. Mirczuk, SE Abbey, SE Abbey-Hosch, SE Abbey-Hosch, SW John, T Sudoh, Victoria J. Lipscomb, Y Komatsu, Y Shimekake   +65 more
core   +3 more sources

The Effects of C-type Natriuretic Peptide on Craniofacial Skeletogenesis [PDF]

Journal of Dental Research, 2012
C-type natriuretic peptide (CNP) is a potent stimulator of long bone and vertebral development via endochondral ossification. In the present study, we investigated the effects of CNP on craniofacial skeletogenesis, which consists of both endochondral and membranous ossification.
K, Nakao, Y, Okubo, A, Yasoda, N, Koyama, K, Osawa, Y, Isobe, E, Kondo, T, Fujii, M, Miura, K, Nakao, K, Bessho   +10 more
openaire   +3 more sources

Overexpression of C-type Natriuretic Peptide in Endothelial Cells Protects against Insulin Resistance and Inflammation during Diet-induced Obesity

Scientific Reports, 2017
The endogenous peptide C-type natriuretic peptide (CNP) binds its receptor, guanylyl cyclase B (GCB), and is expressed by endothelial cells in diverse tissues. Because the endothelial cells of visceral adipose tissue have recently been reported to play a
Cho-Rong Bae, J. Hino, H. Hosoda, Yuji Arai, Cheol Son, H. Makino, T. Tokudome, Tsutomu Tomita, Toru Kimura, T. Nojiri, K. Hosoda, M. Miyazato, K. Kangawa   +12 more
semanticscholar   +1 more source