Results 61 to 70 of about 93,289 (293)

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, EarlyView.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

Is Plasma C-Type Natriuretic Peptide Level Suitable for Diagnosing and Typing Skeletal Dysplasia?

Trends in Pediatrics, 2022
Objective: Skeletal dysplasia is a heterogeneous group of diseases that lead to abnormal enchondral ossification and typing of the disease is quite complex. C-type natriuretic peptide (CNP), one of the members of the natriuretic peptide family, has been
Sirmen Kızılcan Çetin, Damla Gökşen, Samim Özen, Hüdaver Alper, Esra Işık, Su Özgür, Şükran Darcan   +6 more
doaj   +1 more source

Atrial natriuretic peptide, brain natriuretic peptide and c‐type natriuretic peptide: effects on testicular microcirculation and immunohistochemical localization [PDF]

International Journal of Andrology, 1997
The effect of local injection of atrial (ANP), brain (BNP) and C‐type (CNP) natriuretic peptides and an ANP antagonist (HS‐142–1) on testicular microcirculation and vasomotion was studied using laser Doppler flowmetry. The natriuretic peptides were also localized immunohistochemically within the testis.ANP, BNP‐32, CNP‐22 and CNP‐53 all caused a dose ...
Ola Collin, Anders Bergh, Erik Lissbrant
openaire   +3 more sources

Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone‐Glucocorticoid Receptor‐LAMA5 Axis

Advanced Science, EarlyView.
In vivo experiments suggest that cardiomyocyte hypertrophy is an early manifestation of cardiac pathological changes induced by chronic psychological stress. In vivo and in vitro experiments suggest that the corticosterone‐glucocorticoid receptor‐LAMA5 axis mediates cardiomyocyte hypertrophy induced by chronic psychological stress. The clinical results
Chuanjing Zhang, Yongfei Song, Xiaojun Jin, Qingbo Xu, Honghua Ye, Zhuonan Wu, Hui Lin, Jiale Hu, Chen Huang, Jianqing Zhou, Jiangfang Lian   +10 more
wiley   +1 more source

A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation [PDF]

, 2009
Northwestern Europeans are among the tallest of human populations. The increase in body height in these people appears to have reached a plateau, suggesting the ubiquitous presence of an optimal environment in which genetic factors may have exerted a ...
Albert Hofman, Andre G. Uitterlinden, Aulchenko, Aulchenko, Ben A. Oostra, Bocciardi, Boomsma, Brenda W.J.H. Penninx, Claes Ohlsson, Cole, Cornelia M. van Duijn, de Bakker, Devlin, Dorret I. Boomsma, Eco J.C. de Geus, Fan Liu, Fernando Rivadeneira, Garcia, Gilbert, Gonneke Willemsen, Gudbjartsson, Hofman, Hofman, Huberta von Eller-Eberstein, Jan H. Smit, Johansson, Johnson, Jouke Jan Hottenga, Joyce B.J. van Meurs, Jules de Keijzer, Kaneki, Karol Estrada, Kate van Duijn, Knipscheer, Lao, Lei, Lei, Lettre, Li, Lisette Stolk, Lorentzon, Manfred Kayser, Marchini, Matsukawa, Mattias Lorentzon, Michael Krawczak, Natascha Schoor, Nicole Vogelzangs, Paul Lips, Pe'er, Pejchalova, Penninx, Price, Purcell, Sammalisto, Sanna, Silventoinen, Smeets-Goevaers, Soranzo, Stefan Schreiber, Sullivan, Victor Pop, Visscher, Weedon, Weedon, Weedon, Yasoda, Yurii S. Aulchenko   +67 more
core   +9 more sources

The significance of natriuretic peptides in the evaluation of water-salt metabolism in chronic kidney disease

Терапевтический архив, 2014
The paper discusses the molecular, biochemical, and physiological properties of natriuretic peptides, including the clinical applications of their synthetic formulations, as well as the renal and extrarenal mechanisms of water-salt metabolism in chronic ...
A A Pulin, T Iu Kustova, V V Fomin, N A Mukhin   +3 more
doaj  

Peptide‐Based Biomaterials as a Promising Tool for Cancer Radiotherapy

Advanced Science, EarlyView.
This review provides a systematic overview of peptide‐based biomaterials in tumor radiotherapy, covering their roles as both radiosensitizers and radiopharmaceuticals. Peptide‐based radiosensitizers are generally divided into three categories: peptides as direct radiosensitizers, peptides as carriers of radiosensitizers, and targeted‐peptide‐modified ...
Qian Wang, Xinhui Chu, Jianfeng Liu
wiley   +1 more source

Homologous and heterologous desensitization of guanylyl cyclase-B signaling in GH3 somatolactotropes [PDF]

, 2013
The guanylyl cyclases, GC-A and GC-B, are selective receptors for atrial and C-type natriuretic peptides (ANP and CNP, respectively). In the anterior pituitary, CNP and GC-B are major regulators of cGMP production in gonadotropes and yet mouse models of ...
A Faivre-Bauman, A Rathinavelu, AB Abou-Samra, Abir Mukherjee, AF Gilkes, AH Tashjian Jr, AM Hamad, Andrew J. Lessey, Andrew Sunters, AR Yoder, Bigboy Simbi, CA McArdle, CA McArdle, CA McArdle, Caroline P. Wheeler-Jones, Craig A. McArdle, D Fan, D Müller, DJ Hartt, DM Dickey, FN Zeytin, G Rousseau, Gary F. Baxter, GY Koh, H Chusho, H Hao, I Kishimoto, Iain R. Thompson, Imelda M. McGonnell, IR Thompson, IR Thompson, J Horvath, KN Pandey, KN Pandey, Lorna Smith, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, LR Potter, MA Vieira, Mark S. Roberson, MB Henesy, MJ Lopez, N Tamura, PM Hinkle, RC Fowkes, RC Fowkes, RC Fowkes, RC Fowkes, Robert C. Fowkes, S Inagaki, S Suga, SA Bayol, Samantha M. Mirczuk, SE Abbey, SE Abbey-Hosch, SE Abbey-Hosch, SW John, T Sudoh, Victoria J. Lipscomb, Y Komatsu, Y Shimekake   +65 more
core   +3 more sources

EBBP‐Mediated Integrated Stress Response Attenuates Anthracycline‐Induced Cardiotoxicity by Inhibiting the Ferroptosis of Cardiomyocytes

Advanced Science, EarlyView.
EBBP expression is significantly upregulated in DOX‐treated cardiomyocytes. Mechanistically, EBBP interacts with GRP78 to mediate K63‐linked ubiquitination, thereby attenuating the inhibitory GRP78‐PERK interaction and triggering activation of the PERK‐mediated integrated stress response (ISR).
Zilong Chen, Can Chen, Yichen Wu, Yinxue Xia, Ruijie Luo, Jiangcheng Shu, Long Chen, Zhaohui Wang, Cheng Wang, Kai Huang   +9 more
wiley   +1 more source

C-Type Natriuretic Peptide and Cardiac Fibrosis [PDF]

Hypertension, 2011
See related article, pp 201–207 C-type natriuretic peptide (CNP), last of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and CNP to be discovered, has proven more difficult to investigate than its alphabetic predecessors, in part because circulating levels fall close to the limits of detection of immunoassays.
openaire   +2 more sources