Results 21 to 30 of about 180,130 (342)

Molecular Mechanism of Blood Pressure Regulation through the Atrial Natriuretic Peptide

open access: yesBiology, 2022
Natriuretic peptides, including atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), have cardioprotective effects and regulate blood pressure in mammals.
Takeshi Tokudome, Kentaro Otani
doaj   +1 more source

Pathogenetic justification of sacubitril / valsartan use in respiratory-cardial comorbidity

open access: yesPatologìâ, 2023
Among the comorbid conditions that significantly worsen quality of life and life expectancy are the chronic obstructive pulmonary disease and heart failure.
T. V. Ashcheulova   +3 more
doaj   +1 more source

Roles of Natriuretic Peptides and the Significance of Neprilysin in Cardiovascular Diseases

open access: yesBiology, 2022
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) activate the guanylyl cyclase A receptor (GC-A), which synthesizes the second messenger cGMP in a wide variety of tissues and cells.
Hitoshi Nakagawa, Yoshihiko Saito
doaj   +1 more source

A novel natriuretic peptide [PDF]

open access: yesBMC Pharmacology, 2011
Background Receptors for the natriuretic peptides (NPs) ANP, BNP and CNP are highly expressed in lung, suggesting that this organ is an important physiological target for NP signalling. By stimulating vasoand bronchodilation and inhibiting cell proliferation and fibrotic processes, NPs may have therapeutic potential in various lung diseases. Mechanisms
Ralf Middendorff   +3 more
openaire   +2 more sources

Npr3 regulates neural crest and cranial placode progenitors formation through its dual function as clearance and signaling receptor

open access: yeseLife, 2023
Natriuretic peptide signaling has been implicated in a broad range of physiological processes, regulating blood volume and pressure, ventricular hypertrophy, fat metabolism, and long bone growth.
Arun Devotta   +3 more
doaj   +1 more source

Natriuretic peptides: Diagnostic and therapeutic use

open access: yesIndian Journal of Endocrinology and Metabolism, 2011
Natriuretic peptides (NPs) are hormones which are mainly secreted from heart and have important natriuretic and kaliuretic properties. There are four different groups NPs identified till date [atrial natriuretic peptide (ANP), B-type natriuretic peptide (
Kaushik Pandit   +3 more
doaj   +1 more source

Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis

open access: yesPhysiological Reports, 2021
Glomerular podocytes play a key role in proteinuric diseases. Accumulating evidence suggests that cGMP signaling has podocyte protective effects. The major source of cGMP generation in podocytes is natriuretic peptides.
Liming Wang   +3 more
doaj   +1 more source

Natriuretic Peptide-Based Novel Therapeutics: Long Journeys of Drug Developments Optimized for Disease States

open access: yesBiology, 2022
The field of natriuretic peptides (NPs) as an endocrine hormone has been developing since 1979. There are three peptides in humans: atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), which bind to the guanylyl cyclase-A (GC-A ...
Tomoko Ichiki   +2 more
doaj   +1 more source

Potential applications of natriuretic peptide system in cardiovascular regenerative medicine [PDF]

open access: yesCellR4, 2022
Cardiovascular diseases are among the major causes of death worldwide. These diseases can be described as circumstances in which cell loss and injury exceed the capacity for regeneration and repair.
M. Öztop
doaj   +1 more source

Natriuretic Peptides

open access: yesJournal of the American College of Cardiology, 2007
Natriuretic peptides (NPs) are released from the heart in response to pressure and volume overload. B-type natriuretic peptide (BNP) and N-terminal-proBNP have become important diagnostic tools for assessing patients who present acutely with dyspnea. The NP level reflects a compilation of systolic and diastolic function as well as right ventricular and
Alan S. Maisel, Lori B. Daniels
openaire   +3 more sources

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