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An Unsuspected Property of Natriuretic Peptides
Circulation, 2012 Background— Although natriuretic peptides are considered cardioprotective, clinical heart failure trials with recombinant brain natriuretic peptide (nesiritide) failed to prove it.
Nahid Seyedi
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American Journal of Kidney Diseases, 2005
Natriuretic peptides are involved in the regulation of volume homeostasis. Their levels generally are increased in the setting of volume expansion and act on multiple effector systems to cause vasodilation and natriuresis in an effort to return volume status back to normal. In patients with end-stage renal disease, the natriuretic capabilities of these
Sergei, Joffy, Mitchell H, Rosner
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Natriuretic peptides are involved in the regulation of volume homeostasis. Their levels generally are increased in the setting of volume expansion and act on multiple effector systems to cause vasodilation and natriuresis in an effort to return volume status back to normal. In patients with end-stage renal disease, the natriuretic capabilities of these
Sergei, Joffy, Mitchell H, Rosner
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Basic Research in Cardiology, 2004
The natriuretic peptides are a family of widely distributed, but evolutionarily conserved, polypeptide mediators that exert a range of actions throughout the body. In cardiovascular homeostasis, the endocrine roles of the cardiac-derived atrial and B-type natriuretic peptide (ANP and BNP) in regulating central fluid volume and blood pressure have been ...
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The natriuretic peptides are a family of widely distributed, but evolutionarily conserved, polypeptide mediators that exert a range of actions throughout the body. In cardiovascular homeostasis, the endocrine roles of the cardiac-derived atrial and B-type natriuretic peptide (ANP and BNP) in regulating central fluid volume and blood pressure have been ...
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The natriuretic peptide family
Current Opinion in Nephrology and Hypertension, 1993The natriuretic peptide system is a complicated system comprising at least three endogenous peptides (atrial natriuretic peptide, brain natriuretic peptide and C-type natriuretic peptide) and three receptors [the atrial natriuretic peptide-A receptor (guanylyl cyclase A), the atrial natriuretic peptide-B receptor (guanylyl cyclase B) and the clearance ...
K, Nakao +4 more
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Physiology of Natriuretic Peptides
Journal of Internal Medicine, 1994De Bold’s discovery 16 yr ago of an atrial tissue factor (1) with strong natriuretic activity understandably captured the imagination of renal physiologists seeking the elusive “third factor” (2) and new insights into sodium regulation. However, as well as natriuresis, de Bold’s original experiments showed that the atrial extract also caused ...
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The natriuretic-peptide family
The Lancet, 1997The discovery in the early 1980s of atrial natriuretic peptide, a circulating peptide with natriuretic/diuretic and vasorelaxant properties was greeted with excitement since the existence of a humoral link between heart and kidney had long been predicted.
M R, Wilkins, J, Redondo, L A, Brown
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American Journal of Obstetrics and Gynecology, 1995
Our purpose was to compare the actions of atrial natriuretic peptide and brain natriuretic peptide in the human placental vasculature.Isolated placental cotyledons were dually perfused with fetal perfusion pressure used as an index of vascular response.
G, Holcberg +4 more
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Our purpose was to compare the actions of atrial natriuretic peptide and brain natriuretic peptide in the human placental vasculature.Isolated placental cotyledons were dually perfused with fetal perfusion pressure used as an index of vascular response.
G, Holcberg +4 more
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Atrial natriuretic peptide and related peptides
Clinical Chemical Laboratory Medicine, 2007AbstractIn recent years, biomarkers have been recognized as important tools for diagnosis, risk stratification, and therapeutic decision-making in cardiovascular diseases. Currently, the clinical potential of several natriuretic peptides is under scientific investigation.
Akashi, Yoshihiro J. +3 more
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Natriuretic Peptides in Septic Patients
Current Medicinal Chemistry, 2009The natriuretic peptide family is comprised of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), C-type natriuretic peptide (CNP), dendroaspis natriuretic peptide - DNP and urodilatin. They play a role in the diagnosis of several diseases, especially those involving the cardiovascular system. Sepsis is a complex condition that can lead
M, Piechota +5 more
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Atrial natriuretic peptide in man
American Journal of Nephrology, 1989The heart is the major source of atrial natriuretic peptides (ANP). A propeptide is stored in atrial myocytes. In normal humans, atrial distension secondary to volume overload and/or increased atrial pressures are thought to stimulate the secretion of biologically active alpha-ANP (ANF-[99-126], 28 amino residues) into the circulation.
Weidmann P +3 more
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