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Natriuretic peptides appeared after their receptors in vertebrates
BMC Evolutionary Biology, 2019 Background In mammals, the natriuretic system contains three natriuretic peptides, NPPA, NPPB and NPPC, that bind to three transmembrane receptors, NPR1, NPR2 and NPR3. The natriuretic peptides are known only in vertebrates.
Anna Grandchamp +2 more
doaj +1 more source
Journal of the American College of Cardiology, 2007 Natriuretic peptides (NPs) are released from the heart in response to pressure and volume overload. B-type natriuretic peptide (BNP) and N-terminal-proBNP have become important diagnostic tools for assessing patients who present acutely with dyspnea. The NP level reflects a compilation of systolic and diastolic function as well as right ventricular and
Alan S. Maisel, Lori B. Daniels
openaire +3 more sources
Natriuretic Peptides: Biochemistry, Physiology, Clinical Implication
Общая реаниматология, 2009 In the past years, the interest of theorists and clinicians has steadily increased in the myocardially secreted hormones – natriuretic peptides. At the Congress of the European Society of Anesthesiology (Munich, 2007), B-type natriuretic peptides ...
I. A. Kozlova, I. Ye. Kharlamova
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2017 A clinical role of biomarkers (especially, natriuretic peptides) is discussed in the article. The most important evidences of clinical effectiveness of using biomarkers in patients with suspected heart failure and in patients with confirmed diagnose of ...
S. R. Gilyarevskiy +2 more
doaj +1 more source
Physiological Reports, 2021 Glomerular podocytes play a key role in proteinuric diseases. Accumulating evidence suggests that cGMP signaling has podocyte protective effects. The major source of cGMP generation in podocytes is natriuretic peptides.
Liming Wang +3 more
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European Journal of Heart Failure, 2019 Cardiac biomarkers are a mainstay in diagnosis of cardiovascular disease but their role in cardio‐oncology has not yet been systematically evaluated. This meta‐analysis aims to determine whether cardiac troponins and (N‐terminal pro) brain natriuretic ...
L. Michel +6 more
semanticscholar +1 more source
Signaling pathways involved in renal oxidative injury: role of the vasoactive peptides and the renal dopaminergic system [PDF]
, 2014 The physiological hydroelectrolytic balance and the redox steady state in the kidney are accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors.
Choi, Marcelo Roberto +6 more
core +3 more sources
Natriuretic Peptides: The Case of Prostate Cancer
Molecules, 2017 Cardiac natriuretic peptides have long been known to act as main players in the homeostatic control of blood pressure, salt and water balance. However, in the last few decades, new properties have been ascribed to these hormones.
Letizia Mezzasoma +3 more
doaj +1 more source
European Journal of Heart Failure, 2018 This study aimed at evaluating the effects of sacubitril/valsartan on neprilysin (NEP), and the metabolism of natriuretic peptides in heart failure (HF) and providing additional mechanistic information on the mode of action of the drug.
H. Nougué +9 more
semanticscholar +1 more source
Designer Natriuretic Peptides [PDF]
Journal of Investigative Medicine, 2009 Designer natriuretic peptides (NPs) are novel hybrid peptides that are engineered from the native NPs through addition, deletion, or substitution of amino acid(s) with a goal toward optimization of pharmacological actions while minimizing undesirable effects.
Hsiao Lieu +2 more
openaire +3 more sources