Results 41 to 50 of about 1,973 (119)

IL‐15 Links Muscle–Kidney Crosstalk to Preserving Podocyte Mitochondrial Fusion and Attenuating Diabetic Nephropathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 2, April 2026.
ABSTRACT Objectives High glucose induces mitochondrial dysfunction in podocytes, contributing to the development of diabetic nephropathy (DN). There is increasing evidence that muscles play a protective role by secreting myokines into the kidneys. Here, we investigated how skeletal muscle influences podocyte health via muscle–kidney crosstalk.
Yin Li, Jialing Rao, Weiyan Lai, Yuxiang Sun, Hongchun Lin, Jun Zhang, Zengchun Ye, Zhaoyong Hu, Hui Peng   +8 more
wiley   +1 more source

Physical activity and meal timing alignment with chronotype and their associations with glucose metabolism: The Maastricht Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 4, Page 3295-3304, April 2026.
Abstract Aims Little is known about how the alignment between daily behaviours, such as physical activity and eating, and chronotype relates to glucose metabolism. We investigated whether alignment of physical activity and meal timing with chronotype was associated with glycaemic parameters and with prediabetes or type 2 diabetes (T2DM).
Marvin Y. Chong, Joseph Henson, Martijn J. L. Bours, Hans Bosma, Bastiaan E. de Galan, Carla J. H. van der Kallen, Ree M. Meertens, Hans H. C. M. Savelberg, Miranda T. Schram, Matty P. Weijenberg, Thomas Yates, Annemarie Koster, Simone J. P. M. Eussen   +12 more
wiley   +1 more source

Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9‐Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Effects of PEPCK deficiency in Trypanosoma cruzi bioenergetics and life stages. ABSTRACT Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes—unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets.
Carolina S. D. Vieira, Wei Wang, Fernando Sanchez‐Valdez, Jihyun Lim, Brooke E. White, Camilla G. S. Souza, Rick L. Tarleton, Marcia C. Paes, Natalia P. A. Nogueira   +8 more
wiley   +1 more source

Mechanical Performance Under Compressive Load of Carboxylated Nitrile Rubber and Kraft Lignin Composites

Polymer Composites, Volume 47, Issue 5, Page 3983-3993, 10 March 2026.
Lignin dispersion in carboxylated nitrile rubber (XNBR) is enhanced at 7% carboxylic acid, significantly improving the composite's compressive mechanical performance for sealing applications. ABSTRACT Lignin is a promising biobased material that enhances the sustainability of rubber composites as a reinforcing filler.
Gustavo Ninho Campos, Elisson Brum Dutra da Rocha, Katrine Paiva, Marcos Vinicus Colaço, Cristina Russi Guimarães Furtado, Marco Antonio Gaya de Figueiredo, Ana Maria Furtado de Sousa   +6 more
wiley   +1 more source

Bis‐Furans: A Sustainable Source of Diverse Molecular Architectures

European Journal of Organic Chemistry, Volume 29, Issue 10, 9 March 2026.
A concise synthetic route to diverse acyclic and heterocyclic compounds has been developed by combining hetero‐Diels–Alder reactions, DBU‐promoted ring openings, and Lewis base‐catalyzed annulations. Nitrosoalkenes reacted with furan derivatives to form 4a,7a‐dihydro‐4H‐furo[2,3‐e][1,2]oxazines, which underwent DBU‐promoted rearrangements to 6H‐1,2 ...
Ana L. Cardoso, José A. Paixão, Teresa M. V. D. Pinho e Melo   +2 more
wiley   +1 more source

Electron–Matter Interactions During Electron Beam Nanopatterning

Advanced Functional Materials, Volume 36, Issue 21, 12 March 2026.
This article reviews the electron–matter interactions important to nanopatterning with electron beam lithography (EBL). Electron–matter interactions, including secondary electron generation routes, polymer radiolysis, and electron beam induced charging, are discussed.
Camila Faccini de Lima, Prathiba Thamizhavel, Taylor J. Woehl   +2 more
wiley   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, Volume 13, Issue 16, 18 March 2026.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Precision‐Engineered Silver Single‐Atom Carbon Dot Nanozymes for Theranostic Management of Acute Kidney Injury

Advanced Science, Volume 13, Issue 16, 18 March 2026.
Mitochondria‐targeted silver single‐atom carbon dot (T‐AgSA‐CDs) nanozymes enable dual SOD/GPx‐like ROS scavenging, real‐time imaging, and therapeutic effects for acute kidney injury (AKI). Atomically dispersed Ag sites synergize with carbon dots to restore renal redox hemostasis, protect mitochondrial function, mitigate inflammation, facilitate post ...
Tianle Tang, Jun Zhang, Yan Wang, Guoping Chen, Kehui Yuan, Yuan He, Chenchen Li, Sumaira Hanif, Yang Yang, Yanli Wang, Pir Muhammad   +10 more
wiley   +1 more source

Copper‐Catalyzed Enantioselective Decarboxylative Cyanation of Carboxylic Acids via Electrophotocatalysis

ChemistryEurope, Volume 4, Issue 3, March 2026.
We report asymmetric decarboxylative cyanation of benzyl carboxylic acids using electrophoto‐ and Cu catalysis. Light‐induced ligand–to–metal charge transfer enables radical decarboxylation, with electrochemical oxidation replacing chemical oxidants. Only a Cu(I) precatalyst is required to mediate both radical generation and enantioselective C–CN bond ...
Xueyao Zhao, Wenzheng Fan, Pinhong Chen, Guosheng Liu   +3 more
wiley   +1 more source