Results 51 to 60 of about 84,052 (266)

Climate and Transformation of Ecosystems by the Example of Natural Plague Foci of South-East of Russia

Проблемы особо опасных инфекций, 2012
Shown was the influence of modern day warming and some other factors on natural plague foci of the European South-East of Russia. Analyzed were the basic mechanisms of transformation of biocenotic structure of natural foci complexes.
A. I. Udovikov, N. V. Popov, L. V. Samoilova, S. I. Tolokonnikova   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

THE ANALYSIS OF DIGITAL MODEL OF SOIL AND GEOGRAPHICAL CONDITIONS OF SMOLENSK REGION AT THE STUDYING OF NATURAL FOCI INFECTIONS (ON TULYAREMIYA'S EXAMPLE)

InterCarto. InterGIS, 2013
This work describes using of soil’s digital model at the studying of natural foci infections. Distribution of natural foci infections depends on a complex of factors, including soil’s conditions.
T. V. Vatlina, S. Evdokimov
doaj   +1 more source

[Tularemia in inactive natural foci].

Zhurnal mikrobiologii, epidemiologii i immunobiologii, 2003
The data on the epidemiological and epizootological manifestations of tularemia on the territory of the Ulyanovsk region are presented. The characteristics describing the process of the of Francisella tularensis circulation as well as the environmental objects, most important for the manifestations of tularemia infection, are given.
A A, Nafeev, A S, Korobeĭnikova, Z V, Briginevich, E I, Sibaeva, N M, Nikishina   +4 more
openaire   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Epizootic Activity of Natural Plague Foci of the Russian Federation in 2015, and Prognosis for 2016

Проблемы особо опасных инфекций, 2016
Objective of the study is to evaluate the state of parasitic systems and activity of natural plague foci of the Russian Federation in 2015 and to develop epizootiological forecast for 2016.
N. V. Popov, V. E. Bezsmertny, A. N. Matrosov, T. V. Knyazeva, A. A. Kuznetsov, Yu. M. Fedorov, V. P. Popov, D. B. Verzhutsky, V. M. Korzun, S. A. Kosilko, E. V. Chipanin, V. M. Dubyansky, O. V. Maletskaya, M. P. Grigor’Ev, E. S. Zenkevich, V. P. Toporkov, S. V. Balakhonov, A. N. Kulichenko, V. V. Kutyrev   +18 more
doaj   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

The Small Molecule Inhibitor of the Type III Secretion System Fluorothiazinone Affects Flagellum Surface Presentation and Restricts Motility in Gram-Negative Bacteria

Antibiotics
Background/Objectives: Fluorothiazinone (FT), a small molecule of the 2,4-disubstituted-4H-[1,3,4]-thiadiazine-5-one class, is known to inhibit the type III secretion system (T3SS) in Gram-negative bacteria and has shown therapeutic potential in animal ...
Alexey Slonov, Mariam Abdulkadieva, Egor Kalinin, Natalya Bondareva, Lydia Kapotina, Svetlana Andreevskaya, Natalia Shevlyagina, Anna Sheremet, Elena Sysolyatina, Vladimir Zhukhovitsky, Mikhail Vasiliev, Oleg Petrov, Svetlana Ermolaeva, Nailya Zigangirova, Alexander Gintsburg   +14 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source