Results 51 to 60 of about 176,569 (255)

Assessment of Ecosystem Services Supply and Demand (Mis)matches for Urban Ecological Management: A Case Study in the Zhengzhou–Kaifeng–Luoyang Cities

Remote Sensing, 2022
Accurate supply and demand matching of ecosystem services (ESs) is important for managing regional ecosystems. On the basis of remote-sensing, meteorological, and socio-economic data, we mapped the supply, demand, and matching status of four ESs (i.e ...
Dong Xue, Zhaojun Wang, Yuan Li, Mengxue Liu, Hejie Wei   +4 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Changes in the food supply capacity of alpine grassland ecosystem: A dialectic synthesis of natural and anthropogenic drivers

Advances in Climate Change Research, 2020
Grassland-based animal husbandry and livestock production is the main contributor to livelihood creation for herdsmen. By using the structural dynamics method, this study quantified the changes in the food supply capacity (FSC) of alpine grassland ecosystem and sensitivity to significant variables.
openaire   +2 more sources

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Planning for a Resilient Urban Food System: A Case Study from Baltimore City, Maryland

Journal of Agriculture, Food Systems, and Community Development, 2018
Many natural and non-natural hazards threaten food security, especially in urban areas where growing populations place extra demands on the food supply.
Erin Biehl, Sarah Buzogany, Kristin Baja, Roni A. Neff   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Driving Mechanisms and Flow Potential of Ecosystem Services Based on a Supply–Demand Perspective in a Developing Region

Ecosystem Health and Sustainability
Ecosystem services are closely associated with human well-being, and a supply–demand mismatch of ecosystem services will be detrimental to sustainable development, particularly in developing regions. The Qinghai–Gansu–Ningxia region in northwestern China
Shuwan Yan, Hao Chen, Quan Quan, Jian Liu   +3 more
doaj   +1 more source

Values-Based Supply Chains as a Strategy for Supporting Small and Mid-Scale Producers in the United States

Agriculture, 2016
Consumers are increasingly interested in the “values” associated with the food they eat and are often willing to pay more for food for which there is a “story” that links farm to fork. The “values” associated with these foods may be that they are locally
Gail Feenstra, Shermain Hardesty
doaj   +1 more source