Results 71 to 80 of about 176,569 (255)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Ecosystem services in the Northern Tianshan Urban Agglomeration: Nonlinear responses to natural and human factors and threshold-based spatial optimization strategies

Journal of Hydrology: Regional Studies
Study Region: The Northern Tianshan Urban Agglomeration, an oasis-dominated corridor along the northern foothills of the Tianshan Mountains in arid north-west China, combines alpine catchments, irrigated plains, and rapidly expanding cities.
Ying Meng, Weixin Du, Li Chen, Zhigang Zhao, Haiyan Du, Zhipeng Li, Mengjie Song, Shala Tuohetaerhan   +7 more
doaj   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Operation Analysis of Refrigerated Display Cabinets Based on Thermal Energy Storage and Cooling Using Natural Cold Source

Zhileng xuebao, 2023
In this study, a simulation model of a natural cold source-based refrigerated display cabinet system is established by using the TRNSYS software. First, the air supply temperature of the display cabinet and the cooling temperature of the coolant are ...
Yuan Pei, He Zhengyang, Liu Aolong, Hou Feng, L, Yanli   +5 more
doaj  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The role of naturally stored food supplies in the winter diet of the boreal Willow Tit Parus montanus

Ornis Svecica, 1994
The average amount of food that was stored during an autumn by Willow Tits Porus montanus was estimated by sampling hoarding intensities and analysing the energetic contents of the stored items. Measurements of retrieval and losses of the stored food made it possible to calculate how much of the stored food that actually was used by the hoarder.
openaire   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

The potential of future foods for a sustainable future

eFood
Future foods have attracted widespread attention due to the view of a sustainable supply of food and nutritional health. At present, the food industry still faces high energy consumption and pollution, which have caused enormous pressure on the ...
Jing Wang, Xin Zhang
doaj   +1 more source

Infaunal bivalves exhibit resilience to ocean acidification but remain sensitive to food supply

Frontiers in Marine Science
Soft-sediment habitats are crucial for marine coastal ecosystems, supporting diverse biodiversity both above and below the sediment. Ocean acidification, driven by rising CO2 and nutrient influx, enhances heterotrophic metabolism, raising CO2 levels and ...
Montserrat Antivero, Montserrat Antivero, Paz Caballero, Paz Caballero, Nicolás Leppes, Nicolás Leppes, Marco A. Lardies, Marco A. Lardies   +7 more
doaj   +1 more source