Results 91 to 100 of about 5,367,272 (280)

Characteristics of oligonucleotide frequencies across genomes: Conservation versus variation, strand symmetry, and evolutionary implications [PDF]

open access: yes, 2008
One of the objectives of evolutionary genomics is to reveal the genetic information contained in the primordial genome (called the primary genetic information in this paper, with the primordial genome defined here as the most primitive nucleic acid ...
Ya-Zhi Huang, Shang-Hong Zhang
core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Experimental Definition of Defects in the Material of the Elastic Body

open access: yesМеханика машин, механизмов и материалов, 2012
In given article it is offered to use own forms of fluctuations as a diagnostic sign for detection of defects in a material of an elastic body. At realization of a way choose some own forms, define supervision parameters in various points of reference ...
A.V. Kasitsyn   +2 more
doaj  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

The natural frequencies of muted circular drums. [PDF]

open access: yesThe Journal of the Acoustical Society of America, 2010
The natural frequencies of circular drum heads are calculated by the use of finite elements. The results for unmuted drum heads are almost identical to the well known analytical solution expressed in Bessel functions. Mutes of various sizes and shapes are used to stop a section of the head from vibrating.
openaire   +1 more source

The state of natural capital: protecting and improving natural capital for prosperity and wellbeing [PDF]

open access: yes, 2019
This is the final version. Available from Defra via the link in this record.This is the Natural Capital Committee’s (NCC) third report to government. The report sets out recommendations to achieve government’s vision, ‘to be the first generation to leave
Natural Capital Committee
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Extending the Cochran rule for the comparison of word frequencies between corpora [PDF]

open access: yes, 2004
We first describe a number of inter-related issues that need to be considered by the researcher when comparing frequencies of linguistic features in two or more corpora.
Rayson, P.   +5 more
core  

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