Results 91 to 100 of about 259,208 (317)

Features of the subpopulation composition of circulating NK and NKT cells in patients with subclinical atherosclerosis of lower limb arteries

open access: yesАтеросклероз, 2020
Aim of the study was to investigate the features of the subpopulation composition of circulating NK and NKT cells and their diagnostic value in middle-aged patients, depending on the presence of subclinical atherosclerosis of lower limb arteries ...
V. V. Genkel   +5 more
doaj   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian   +6 more
wiley   +1 more source

Cytotoxic capacity of IL-15-stimulated cytokine-induced killer cells against human acute myeloid leukemia and rhabdomyosarcoma in humanized preclinical mouse models [PDF]

open access: yes, 2012
Allogeneic stem cell transplantation (allo-SCT) has become an important treatment modality for patients with high-risk acute myeloid leukemia (AML) and is also under investigation for soft tissue sarcomas.
Wels, Winfried   +35 more
core   +1 more source

Natural Killer Cell and Large Granular Lymphocyte Deficiency in the Gut of Children with Inflammatory Bowel Disease

open access: yesCanadian Journal of Gastroenterology, 1990
The occurrence of natural killer cells and large granular lymphocytes (LGL) within the epithelium of colonic mucosa in children with inflammatory bowel disease (IBD) was compared to normal controls.
F Hadziselimovic, LR Emmons, U Schaub
doaj   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

open access: yesArthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah   +8 more
wiley   +1 more source

Natural killer cells as immunotherapy to target rapidly evolving non-small cell lung carcinoma [PDF]

open access: yes, 2021
Non-small cell lung carcinoma (NSCLC) is a hard-to-treat, high mortality cancer in need of more effective therapy options. Natural killer (NK) cells are innate lymphocytes that contribute to anti-tumor functions through direct cell lysis and cytokine ...
Schwartz, Sarah
core  

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

open access: yesArthritis Care &Research, Accepted Article.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss   +9 more
wiley   +1 more source

Swelling‐Programmed Topographical Guidance for Dynamic Spheroid Self‐Assembly via a Mechanochemical Hydrogel Niche

open access: yesAdvanced Functional Materials, EarlyView.
A swelling‐programmed micropatterned hydrogel guides adherent cells through a controlled transition from cell–matrix anchoring to cadherin‐mediated cell–cell compaction, enabling rapid assembly of high‐viability spheroids with defined size and morphology.
Han Gyeol Nam   +8 more
wiley   +1 more source

Natural killer cells and autoimmunity.

open access: yesArthritis research & therapy, 2004
Autoimmune diseases are often characterized as clinical syndromes caused by the inappropriate activation of T or B cells resulting in systemic or organ-specific damage. However, studies support a role for the innate immune system, and in particular natural killer (NK) cells, in stimulating or suppressing autoimmunity.
French, Anthony R, Yokoyama, Wayne M
openaire   +2 more sources

SURFACE SIALIC ACID OF TUMOR CELLS INVERSELY CORRELATES WITH SUSCEPTIBILITY TO NATURAL KILLER CELL MEDIATED LYSIS [PDF]

open access: yes, 1982
This chapter describes the properties of surface sialic acid of tumor cells, which inversely correlates with susceptibility to natural killer cell mediated lysis.
Ganesa Yogeeswaran   +17 more
core   +1 more source

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