Results 71 to 80 of about 259,208 (317)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Human acute myeloid leukemia CD34+CD38− stem cells are susceptible to allorecognition and lysis by single KIR-expressing natural killer cells

Haematologica, 2009
The concept of tumor immunosurveillance has raised prospects for natural killer cell-based immunotherapy of human cancer. The cure of acute myeloid leukemia may depend on eradication of leukemic stem cells, the self-renewing component of leukemia ...
Ulrich Langenkamp, Uwe Siegler, Simon Jörger, Stefan Diermayr, Alois Gratwohl, Christian P. Kalberer, Aleksandra Wodnar-Filipowicz   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk [PDF]

, 2012
Natural killer (NK) cells play a critical role in antitumor immunity, their activation being regulated through NK cell receptors. Although the endogenous ligands for these receptors are largely unknown, viral ligands have been identified. We investigated
Bateman, Andrew R, Elliott, Tim, James, Edward, Chinnery, Fay, King, Catherine A   +4 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Natural Killer Cells in Asthma

Frontiers in Immunology, 2013
The worldwide prevalence, morbidity, and mortality of asthma have dramatically increased over the last few decades and there is a clear need to identify new, effective, therapeutic and prophylactic strategies. Despite high numbers of NK cells in the lung
Khalil eKarimi, Paul eForsythe
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. [PDF]

, 2012
Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive.
Irene Tirado-González, Gabriela Barrientos, Winterhager Elke, Barrientos Gabriela, Petra von Kwiatkowski (130217), Victor L. J. L. Thijssen (130213), Petra von Kwiatkowski, Burghard F. Klapp (130219), Blois, Sandra M., von Kwiatkowski, P., von Kwiatkowski Petra, Gabriela Barrientos (130201), Irene Tirado González (130195), González, I.T., Petra Moschansky (130215), Freitag, Nancy, Victor L J L Thijssen, Elke Winterhager (130222), González Irene Tirado, Klapp, Burghard F., Petra Moschansky, Freitag, N., Teresa Otto (130209), Tirado González, Irene, Nancy Freitag (130205), Gonzalez, Irene T., Barrientos, Gabriela, Bauersachs, Stefan, Nancy Freitag, Blois, S.M., Elke Winterhager, von Kwiatkowski, Petra, Thijssen, V.L.J.L., Freitag Nancy, Kwiatkowski, Petra von, Winterhager, E., Thijssen Victor L. J. L., Stefan Bauersachs (130224), Sandra M. Blois (130225), Bauersachs Stefan, Otto Teresa, Klapp, B.F., Moschansky, P., Stefan Bauersachs, Moschansky Petra, Thijssen, Victor L., Bauersachs, S., Teresa Otto, Klapp Burghard F., Barrientos, G., Burghard F Klapp, Barrientos, Gabriela Laura, Winterhager, Elke, Thijssen, Victor L. J. L., Moschansky, Petra, Otto, Teresa, Otto, T., Blois Sandra M., Sandra M Blois   +58 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Development of antibody technology to identify natural killer cell surface antigens in Xenopus Laevis [PDF]

, 1999
Natural killer (NK)-like lymphocytes have recently been identified in thymectomised (Tx) Xenopus which are capable of spontaneous cytotoxicity towards the MHC- deficient, allogeneic thymus tumour cell line B(_3)B(_7).
Minter, Ralph
core