Results 51 to 60 of about 9,361,396 (309)

Identification of the ancestral killer immunoglobulin-like receptor gene in primates [PDF]

, 2006
Background: Killer Immunoglobulin-like Receptors (KIR) are essential immuno- surveillance molecules. They are expressed on natural killer and T cells, and interact with human leukocyte antigens.
Penny Coggill, Hanne Andersen, Sambrook Jennifer G, Piatak Mike, Carrington Mary, Jennifer G Sambrook, Coggill, P, Stephan Beck, Carrington, M, Piatak, M, Vernikos George S, Mike Piatak, Vernikos, GS, Bashirova Arman, Beck Stephan, Coggill Penny, Bashirova, A, Lifson, JD, Andersen, H, George S Vernikos, Lifson Jeff D, Beck, S, Jeff D Lifson, Andersen Hanne, Arman Bashirova, Mary Carrington, Sambrook, JG   +26 more
core   +1 more source

Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster. [PDF]

PLoS ONE, 2018
The pathogenesis of herpes zoster is closely linked to reduced varicella-zoster virus-specific cell-mediated immunity. However, little is known about the interplay between natural killer cells and psychological stress in the pathogenesis of herpes zoster.
Choon Kwan Kim, Youn Mi Choi, Eunsin Bae, Mihn Sook Jue, Hyung Seok So, Eung-Soo Hwang   +5 more
doaj   +1 more source

Cytokines impact natural killer cell phenotype and functionality against glioblastoma in vitro

Frontiers in Immunology, 2023
ObjectiveNatural killer (NK) cells are a part of the innate immune system and first-line defense against cancer. Since they possess natural mechanisms to recognize and kill tumor cells, NK cells are considered as a potential option for an off-the-shelf ...
Minna Sivonen, Minna Sivonen, Katja A. Sirviö, Sara Wojciechowski, Anssi Kailaanmäki, Satu Kaipainen, Aubrey Bailey, Martin Villalba, Martin Villalba, Tuija Kekarainen   +9 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Natural killer cell evolution: cellular and molecular studies on Xenopus [PDF]

, 1996
The presence of natural killer cells at lower evolutionary levels was investigated in the amphibian Xenopus laevis. Chromium release microcytotoxicity assays revealed that fresh splenocytes from early-thymectomised Xenopus displayed significant ...
Horsham, Karen
core  

Tumor-Infiltrating Natural Killer Cells

, 2021
International audienceBecause of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments.
Chiossone, Laura, Vivier, Eric, Narni-Mancinelli, Emilie, Cózar, Beatriz, Greppi, Marco, Carpentier, Sabrina, Vivier, Eric(Cozar and Greppi are CO-FIRST AUTHORS)   +6 more
core   +1 more source

Relative expression of receptors in uterine natural killer cells compared to peripheral blood natural killer cells

Frontiers in Immunology, 2023
One would expect maternal immune cells to attack the invading trophoblast as the placenta is semi-allogenic. However, they appear to cooperate with the trophoblast in disrupting the arterial wall which has been determined in several studies.
Nurul Izza Ismail
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Low-intensity Pulsed Ultrasound Enhances NK Cell Adoptive Therapy by Modulating the Wnt/β-catenin Signaling Pathway

BIO Integration
Natural killer cell adoptive therapy is a novel immunotherapy strategy for the treatment of multiple refractory tumors, including ovarian cancer. However, natural killer cells’ anti-tumor effectiveness is limited by their viability and cytotoxicity.
Renjie Feng, Ao Gu, Gökhan Zengin, Meng Du   +3 more
doaj   +1 more source

Invariant Natural Killer T Cells

Antibodies, 2013
Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 ...
Antonella Cianferoni
doaj   +1 more source