Results 31 to 40 of about 8,634,563 (254)

Therapeutic Applications: Natural Killer Cells [PDF]

Journal of Clinical and Diagnostic Research, 2018
Natural Killer (NK) cells are potent cytotoxic effector cells for cancer therapy and also for keeping severe viral infections in check. Since, they represent only 10% of the lymphocytes and are often dysfunctional, there are technical challenges in ...
Preeti Sharma, Pradeep Kumar, Rachna Sharma   +2 more
doaj   +1 more source

Matched sizes of activating and inhibitory receptor/ligand pairs are required for optimal signal integration by human Natural Killer cells [PDF]

, 2010
It has been suggested that receptor-ligand complexes segregate or co-localise within immune synapses according to their size, and this is important for receptor signaling.
Mehrabi, M, Brzostek, Joanna, Nigel J Burroughs, Stephane Oddos, Nigel J. Burroughs, Harrison, A, Van der Merwe, Philip Anton, Eissmann, P, Miloserdov, V, Maryam Mehrabi, Daniel M Davis, Koehler, Karsten, Daniel M. Davis, Gould, K, Alice Harrison, Köhler, K, Harrison Alice, Eissmann, Philipp, Oddos, S, Shiqiu Xiong, Davis, Daniel M., Köhler Karsten, Xiong, S, Burroughs, NJ, Köhler, Karsten, Cordoba, Shaun-Paul, Philipp Eissmann, Oddos, Stephane, Xiong, Shiqiu, Miloserdov, Vladimir, Gould Keith, Philip Anton van der Merwe, Davis, DM, Mehrabi, Maryam, Xiong Shiqiu, Cordoba, SP, Burroughs, Nigel J, Davis Daniel M., Miloserdov Vladimir, van der Merwe, PA, Brzostek, J, van der Merwe Philip Anton, Mehrabi Maryam, Karsten Köhler, Burroughs Nigel J., Harrison, Alice, Joanna Brzostek, Cordoba, Shaun Paul, Oddos Stephane, van der Merwe, Philip, Shaun-Paul Cordoba, Burroughs, Nigel J., Cordoba Shaun-Paul, Davis, Daniel M, Burroughs, Nigel John, Gould, Keith, Keith Gould, Vladimir Miloserdov, Eissmann Philipp, Brzostek Joanna   +59 more
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Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]

, 2007
Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten, Ulrich H Koszinowski, Rupp Brigitte, Eric Vivier, Ruzsics, Zsolt, Koszinowski Ulrich H, Cornillon, Amélie, Dalod Marc, Bessou Gilles, Koszinowski, Ulrich H, Marc Dalod, Sacher Torsten, Robbins, Scott H., Torsten Sacher, Tomasello Elena, Dalod, Marc, Scott H Robbins, Nicolas Zucchini, Ruzsics Zsolt, Koszinowski, Ulrich H., Zsolt Ruzsics, Elena Tomasello, Gilles Bessou, Bessou, Gilles, Tomasello, Elena, Cornillon Amélie, Vivier Eric, Vivier, Eric, Zucchini, Nicolas, Amélie Cornillon, Brigitte Rupp, Zucchini Nicolas, Robbins, Scott H, Robbins Scott H, Rupp, Brigitte   +34 more
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Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

PLoS ONE, 2019
Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka, Tsutomu Nakazawa, Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Koji Omoto, Yoichi Shida, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Hiromichi Morita, Takahiro Tsujimura, Hiroyuki Nakase   +12 more
doaj   +1 more source

Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity

Haematologica, 2009
Background Bortezomib is a selective and potent inhibitor of the proteasome and has prominent effects in vitro and in vivo against tumors. Very recently, cytotoxic effects of bortezomib on immune-competent cells such as T cells and dendritic cells were ...
Xiangling Wang, Astrid Ottosson, Chunyan Ji, Xiaoli Feng, Magnus Nordenskjöld, Jan-Inge Henter, Bengt Fadeel, Chengyun Zheng   +7 more
doaj   +1 more source

Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. [PDF]

PLoS ONE, 2015
The analysis of gene function in mature and activated natural killer cells has been hampered by the lack of model systems for Cre-mediated recombination in these cells.
Yiying Xu, Cesar Evaristo, Maria-Luisa Alegre, Sandeep Gurbuxani, Barbara L Kee   +4 more
doaj   +1 more source

Natural killer cell deficiency [PDF]

Journal of Allergy and Clinical Immunology, 2013
Natural killer (NK) cells are part of the innate immune defense against infection and cancer and are especially useful in combating certain viral pathogens. The utility of NK cells in human health has been underscored by a growing number of persons who are deficient in NK cells and/or their functions. This can be in the context of a broader genetically
openaire   +2 more sources

Multifunctional human CD56low CD16low natural killer cells are the prominent subset in bone marrow of both healthy pediatric donors and leukemic patients

Haematologica, 2015
We phenotypically and functionally characterized a distinct CD56low natural killer cell subset based on CD16 expression levels in bone marrow and peripheral blood of healthy children and pediatric patients with acute lymphoblastic leukemia.
Helena Stabile, Paolo Nisti, Stefania Morrone, Daria Pagliara, Alice Bertaina, Franco Locatelli, Angela Santoni, Angela Gismondi   +7 more
doaj   +1 more source

Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]

, 2013
Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Gregson, John NS, Gazzard, Brian G, Goodier, Martin R, Kuri-Cervantes, Leticia, Mela, Christopher M, Bower, Mark   +5 more
core   +1 more source

Cord blood Vα24-Vβ11 natural killer T cells display a Th2-chemokine receptor profile and cytokine responses [PDF]

, 2011
Background: The fetal immune system is characterized by a Th2 bias but it is unclear how the Th2 predominance is established. Natural killer T (NKT) cells are a rare subset of T cells with immune regulatory functions and are already activated in utero ...
Elfriede Noessner, Krauss-Etschmann, S., Faber Fabienne L., Harner, Susanne, Harner, S., Nadas, Korinna, Leumann-Runge Anke, Leumann-Runge, A., Leumann-Runge, Anke, Susanne Harner, Korinna Nadas, Nadas, K., Joachim Heinrich, Heinrich, Joachim, Fabienne L Faber, Nadas Korinna, Heinrich, J., Noessner Elfriede, Noessner, Elfriede, Anke Leumann-Runge, Schiemann, Matthias, Susanne Krauss-Etschmann, Krauss-Etschmann Susanne, Fabienne L. Faber, Schiemann Matthias, Nößner, E., Faber, Fabienne L., Krauss-Etschmann, Susanne, Schiemann, M., Faber, F.L., Heinrich Joachim, Harner Susanne, Matthias Schiemann, Harner, S;Noessner, E;Nadas, K;Leumann-Runge, A;Schiemann, M;Faber, FL;Heinrich, J;Krauss-Etschmann, S   +33 more
core   +2 more sources