Results 31 to 40 of about 401,106 (204)

Proteasome inhibition induces apoptosis in primary human natural killer cells and suppresses NKp46-mediated cytotoxicity

Haematologica, 2009
Background Bortezomib is a selective and potent inhibitor of the proteasome and has prominent effects in vitro and in vivo against tumors. Very recently, cytotoxic effects of bortezomib on immune-competent cells such as T cells and dendritic cells were ...
Xiangling Wang, Astrid Ottosson, Chunyan Ji, Xiaoli Feng, Magnus Nordenskjöld, Jan-Inge Henter, Bengt Fadeel, Chengyun Zheng   +7 more
doaj   +1 more source

Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. [PDF]

PLoS ONE, 2015
The analysis of gene function in mature and activated natural killer cells has been hampered by the lack of model systems for Cre-mediated recombination in these cells.
Yiying Xu, Cesar Evaristo, Maria-Luisa Alegre, Sandeep Gurbuxani, Barbara L Kee   +4 more
doaj   +1 more source

'Unlicensed' natural killer cells dominate the response to cytomegalovirus infection. [PDF]

, 2010
Natural killer (NK) cells expressing inhibitory receptors that bind to self major histocompatibility complex (MHC) class I are 'licensed', or rendered functionally more responsive to stimulation, whereas 'unlicensed' NK cells lacking receptors for self ...
Lanier, Lewis L, Murphy, William J, Orr, Mark T   +2 more
core   +3 more sources

Multifunctional human CD56low CD16low natural killer cells are the prominent subset in bone marrow of both healthy pediatric donors and leukemic patients

Haematologica, 2015
We phenotypically and functionally characterized a distinct CD56low natural killer cell subset based on CD16 expression levels in bone marrow and peripheral blood of healthy children and pediatric patients with acute lymphoblastic leukemia.
Helena Stabile, Paolo Nisti, Stefania Morrone, Daria Pagliara, Alice Bertaina, Franco Locatelli, Angela Santoni, Angela Gismondi   +7 more
doaj   +1 more source

Structural equation model testing and the quality of natural killer cell activity measurements [PDF]

, 2005
Background Browne et al. [Browne, MacCallum, Kim, Andersen, Glaser: When fit indices and residuals are incompatible. Psychol Methods 2002] employed a structural equation model of measurements of target cell lysing by natural killer cells as an example ...
Leslie A Hayduk, Hannah Pazderka-Robinson, Greta G Cummings, Merry-Jo D Levers, Melanie A Beres, MW Browne, BL Andersen, BL Andersen, LA Hayduk, KG Joreskog   +9 more
core   +2 more sources

Natural killer cells in hepatitis B virus infection

Brazilian Journal of Infectious Diseases, 2015
Natural killer cells are a unique type of lymphocytes with cytotoxic capacity, and play important roles against tumors and infections. Recently, natural killer cells have been increasingly valued in their effects in hepatitis B virus infection.
Shao-fei Wu, Wen-jing Wang, Yue-qiu Gao
doaj   +1 more source

Signal processing in slit-scan flow cytometry of cell conjugates [PDF]

, 1993
The design and implementation of a real-time signal processing system for slit-scan flow cytometry is described. The system is used to measure the separate scatter and fluorescence peak heights of 2 adherent cells.
Bakker Schut, Dimitrov, Gray, Koolwijk, Radoševic, Radoševic, Robinson, van Oven, Weier, Wheeless   +9 more
core   +2 more sources

Interferon therapy shifts natural killer subsets among Egyptian patients with chronic hepatitis C

Brazilian Journal of Infectious Diseases, 2010
Natural killer cells can be divided into five subpopulations based on the relative expression of CD16 and CD56 markers. The majority of natural killer cells are CD56dim, which are considered to be the main cytotoxic effectors.
Amal Fathy, Mohamed Mohy Eldin, Lobna Metwally, Mohamed Eida, Marwa Abdel-Rehim, Gamal Esmat   +5 more
doaj   +1 more source

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Candida albicans evades NK cell elimination via binding of Agglutinin-Like Sequence proteins to the checkpoint receptor TIGIT

Nature Communications, 2022
Natural killer cells have emerged as critical immune cells in the response to fungal infection. Here the authors identify how Candida albicans evades the natural killer cell response via expression of ligands that directly modify the natural killer cell ...
Yoav Charpak-Amikam, Tom Lapidus, Batya Isaacson, Alexandra Duev-Cohen, Tal Levinson, Adi Elbaz, Francesca Levi-Schaffer, Nir Osherov, Gilad Bachrach, Lois L. Hoyer, Maya Korem, Ronen Ben-Ami, Ofer Mandelboim   +12 more
doaj   +1 more source