Results 21 to 30 of about 226,655 (267)
Natural Killer Cells in Psoriasis [PDF]
Journal of Innate Immunity, 2011 Psoriasis is one of the most common immune-mediated disorders. There is evidence that it is mediated by Th1 and, more recently, Th17 cells. The cytokine pattern, particularly the dominance of TNF-α, implicates the innate immune system in psoriasis pathogenesis. Of the many components of the innate immune system known to be involved in psoriatic lesions,
A M, Tobin +3 more
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Effects of anti-NKG2A antibody administration on leukemia and normal hematopoietic cells
Haematologica, 2016 Natural killer cells are key cells of the innate immune system. Natural killer cell receptor repertoires are diversified by a stochastic expression of killer-cell-immunoglobulin-like receptors and lectin-like receptors such as NKG2 receptors.
Loredana Ruggeri +10 more
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Natural killer cell deficiency [PDF]
Journal of Allergy and Clinical Immunology, 2013 Natural killer (NK) cells are part of the innate immune defense against infection and cancer and are especially useful in combating certain viral pathogens. The utility of NK cells in human health has been underscored by a growing number of persons who are deficient in NK cells and/or their functions. This can be in the context of a broader genetically
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Therapeutic Applications: Natural Killer Cells [PDF]
Journal of Clinical and Diagnostic Research, 2018 Natural Killer (NK) cells are potent cytotoxic effector cells for cancer therapy and also for keeping severe viral infections in check. Since, they represent only 10% of the lymphocytes and are often dysfunctional, there are technical challenges in ...
Preeti Sharma +2 more
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Natural Killer Cell Memory [PDF]
Immunity, 2015 Natural killer (NK) cells have historically been considered short-lived cytolytic cells that can rapidly respond against pathogens and tumors in an antigen-independent manner and then undergo cell death. Recently, however, NK cells have been shown to possess traits of adaptive immunity and can acquire immunological memory in a manner similar to that of
O’Sullivan, Timothy E +2 more
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PLoS ONE, 2019 Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka +12 more
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Haematologica, 2009 Background Bortezomib is a selective and potent inhibitor of the proteasome and has prominent effects in vitro and in vivo against tumors. Very recently, cytotoxic effects of bortezomib on immune-competent cells such as T cells and dendritic cells were ...
Xiangling Wang +7 more
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Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage. [PDF]
PLoS ONE, 2015 The analysis of gene function in mature and activated natural killer cells has been hampered by the lack of model systems for Cre-mediated recombination in these cells.
Yiying Xu +4 more
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Haematologica, 2015 We phenotypically and functionally characterized a distinct CD56low natural killer cell subset based on CD16 expression levels in bone marrow and peripheral blood of healthy children and pediatric patients with acute lymphoblastic leukemia.
Helena Stabile +7 more
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Hematology/Oncology and Stem Cell Therapy, 2015 Natural killer (NK) cells constitute our bodies' frontline defense system, guarding against tumors and launching attacks against infections. The activities of NK cells are regulated by the interaction of various receptors expressed on their surfaces with cell surface ligands.
Mandal, Arundhati, Viswanathan, Chandra
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