Natural killer cell-mediated immunopathology in recurrent pregnancy losses
Exploration of Immunology, 2022 Natural killer (NK) cells have a dual role in human reproduction for maternal-fetal tolerance and protection from infection. During the ovarian cycle and pregnancy, peripheral NK (pNK) and uterine NK (uNK) cells dynamically change their proportions and ...
Thanh Luu +7 more
doaj +1 more source
Skin TLR7 triggering promotes accumulation of respiratory dendritic cells and natural killer cells. [PDF]
, 2012 The TLR7 agonist imiquimod has been used successfully as adjuvant for skin treatment of virus-associated warts and basal cell carcinoma. The effects of skin TLR7 triggering on respiratory leukocyte populations are unknown.
Lohmeyer, Jürgen +29 more
core +1 more source
Tumor-Infiltrating Natural Killer Cells [PDF]
, 2021 International audienceBecause of their potent antitumor activity and their proinflammatory role, natural killer (NK) cells are at the forefront of efforts to develop immuno-oncologic treatments.
Chiossone, Laura +6 more
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Fasting enhances TRAIL-mediated liver natural killer cell activity via HSP70 upregulation.
PLoS ONE, 2014 Acute starvation, which is frequently observed in clinical practice, sometimes augments the cytolytic activity of natural killer cells against neoplastic cells. In this study, we investigated the molecular mechanisms underlying the enhancement of natural
Vu T A Dang +7 more
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Unraveling Natural Killer T-Cells Development
Frontiers in Immunology, 2018 Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
doaj +1 more source
Natural killer cytolytic activity [PDF]
, 2010 Natural killer (NK)–mediated cellular killing has been extensively studied over the past 35 years and the current “granule exocytosis” model integrates work from many investigators to outline the primary means of NK cytotoxicity.
de Armas, Lesley R +3 more
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Highly activated and expanded natural killer cells for multiple myeloma immunotherapy
Haematologica, 2012 Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound ...
Tarun K. Garg +19 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The role of natural killer cells in adaptive immune responses [PDF]
Human natural killer (NK) cells have been shown to respond to numerous pathogenic stimuli, producing IFN-y as well as cytolytic effector molecules such as perforin and granzymes.
Horowitz, Amir
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Tumor recognition by natural killer cells in acute myeloid leukemia and after hematopoietic stem cell transplantation [PDF]
, 2005 Natural killer (NK) cell-mediated cytolytic activity against tumors requires the engagement of activating NK cell receptors by the tumor-associated ligands.
Nowbakht, Pegah
core +1 more source