Results 241 to 250 of about 425,656 (354)

Impaired interferon-gamma production and associated interleukin-12 signalling of CD56bright Natural killer cells following severe trauma

, 2019
Holger Kleinertz
openalex   +2 more sources

Early disease progression in patients with localized natural killer/T‐cell lymphoma treated with concurrent chemoradiotherapy [PDF]

, 2018
Motoko Yamaguchi, Ritsuro Suzuki, Seok Jin Kim, Young Hyeh Ko, Masahiko Oguchi, Naoko Asano, Kana Miyazaki, Yasuhiko Terui, Nobuko Kubota, Takeshi Maeda, Yukio Kobayashi, Jun Amaki, Toshinori Soejima, Bungo Saito, Emiko Shimoda, Noriko Fukuhara, Norifumi Tsukamoto, Kazuyuki Shimada, Ilseung Choi, Takahiko Utsumi, Yasuo Ejima, Won Seog Kim, Naoyuki Katayama   +22 more
openalex   +1 more source

Neutrophil Extracellular Trap Reprograms Cancer Metabolism to Form a Metastatic Niche Promoting Non‐Small Cell Lung Cancer Brain Metastasis

Advanced Science, EarlyView.
This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen, Karrie M. Kiang, Fangkun Liu, Chuntao Li, Xizhe Li, Chen Weiwei, Xin Fu, Gelei Xiao, Jingyi Sun, Erhan Da, Junbo Liao, Hongshu Zhou, Li Meng, Li Zhou, Tao Song, Longbo Zhang, Gilberto Ka‐Kit Leung, Liyang Zhang   +17 more
wiley   +1 more source

Harnessing innate immunity: natural killer cells and innate immune responses in reservoir clearance. [PDF]

Curr Opin HIV AIDS
Schiering K, Beiersdorfer M, Hoelzemer A.   +2 more
europepmc   +1 more source

Single‐Cell Dissection Reveals Immune Dysregulation After CD5 or CD7‐Directed Chimeric Antigen Receptor T‐Cell Therapy

Advanced Science, EarlyView.
Single‐cell RNA/TCR/BCR sequencing reveals that 5CAR therapy in T‐ALL induces T‐cell exhaustion, reduces EBV‐associated TCRs, lowers TCR/BCR diversity, and increases NK/DC/monocyte activation and function. In contrast, 7CAR therapy reduces multiple pathogen‐associated TCRs, enhances NK cell activation and function, decreases monocyte activation, and ...
Yuechen Luo, Haixiao Zhang, Kaiting Tang, Yiming Wang, Huajiang Dong, Wei Qi, Lingling Shan, Yue Tan, Liping Zhao, Jun Shi, Erlie Jiang, Jing Pan, Xiaoming Feng   +12 more
wiley   +1 more source

Adjusting the scope of natural killer cells in cancer therapy. [PDF]

Cell Mol Immunol
Shen Z, Meng X, Rautela J, Chopin M, Huntington ND.   +4 more
europepmc   +1 more source

Natural Killer Cell Immune Checkpoints and Their Therapeutic Targeting in Cancer Treatment

Anqi Lin, Peina Ye, Zhengrui Li, Aimin Jiang, Zaoqu Liu, Quan Cheng, Jian Zhang, Peng Luo   +7 more
openalex   +1 more source

DEL‐1 is an Endogenous Senolytic Protein that Inhibits Senescence‐Associated Bone Loss

Advanced Science, EarlyView.
Senescent bone marrow stromal cells accumulate in the aging bone microenvironment, promoting bone degeneration. DEL‐1, an endogenous secreted protein, acts as a natural senolytic that selectively eliminates these cells. By engaging a β3 integrin/CD73/adenosine/p38 MAPK/BCL‐2 pathway, DEL‐1 counters aging‐related bone loss, revealing promising ...
Jong‐Hyung Lim, Kridtapat Sirisereephap, Hui Wang, Giulia Trimaglio, Kyoung‐Jin Chung, Jonathan Korostoff, Tetsuhiro Kajikawa, Xiaofei Li, Meircurius D.C. Surboyo, Tomoki Maekawa, Triantafyllos Chavakis, George Hajishengallis   +11 more
wiley   +1 more source

Selective agonists of KIR and NKG2A to evade missing self response of natural killer cells. [PDF]

Sci Rep
Hiura S, Kuwasaki Y, Nishikawa Y, Kimura T, Yoshida S, Nakayama M, Makino T, Ueno S.   +7 more
europepmc   +1 more source

Retinoic Acid Reprograms Mast Cells Toward a Proinflammatory State to Enhance Antitumor Immunity

Advanced Science, EarlyView.
Proinflammatory mast cells represent an MHC‐IIhigh, cytokine‐producing mast cell subset associated with improved survival and enhanced responses to anti‐PD‐1 therapy. Retinoic acid drives their polarization, enabling antigen uptake and presentation, and T cell recruitment and activation, collectively promoting adaptive anti‐tumor immunity.
Lizao Zhang, Siqi Ren, Yuhui Li, Rongxi Chen, Ling Qiu, Yongmei Tan, Suling Chen, Huiqian Wu, Lianxi Mai, Xiao Tan, Xin Liu, Peisheng Liang, Shijia Kuang, Liansheng Wang, Jingkang Liu, Jintao Li, Yanyan Li, Qiuping Xu, Yongzhi Su, Yuehai Luo, Binyan Wu, Zijing Huang, Haotian Cao, Qunxing Li, Jinsong Li, Tianjun Lan   +25 more
wiley   +1 more source