Results 271 to 280 of about 425,656 (354)

<i>Epimedium brevicornu</i> Maxim. extract activates natural killer cells against hepatocellular carcinoma via the cGAS-STING pathway. [PDF]

Front Pharmacol
Liu L, Zhan X, Wang X, Wen J, He C, Chen X, Guo Y, Wang X, Li L, Cheng H, Bai Z, Xiao X.   +11 more
europepmc   +1 more source

Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms

, 2009
Davide Bagnara, Adalberto Ibatici, Mirko Corselli, Nadia Sessarego, Claudya Tenca, Amleto De Santanna, Andrea Nicola Mazzarello, Antonio Daga, Renzo Corvò, Giulio Rossi, Francesco Frassoni, Ermanno Ciccone, Franco Fais   +12 more
openalex   +2 more sources

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, EarlyView.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Natural killer cells and IFN-γ protect against liver injury during HAV infection in mice. [PDF]

J Virol
Misumi I, Li Y, Shirasaki T, Yang L, Kapustina M, Lemon SM, Whitmire JK.   +6 more
europepmc   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer cells

Leborgne NG, Acklam J, Hogg AJ, Albakova Z, Hogg KG, Robinson KS, Calder G, Villamin A, Robson C, Pealing F, Care MA, Gonka M, Fox JM, Iremonger J, Hewitson JP, Kent DG, Layton AM, Pearson FE, Noble ME, Grey W, Barlow JL, Boucher D.   +21 more
europepmc   +1 more source

Natural Killer Cells Are Dispensable for Virus Control in Rag2^-/- Mice During Primary RSV Infection. [PDF]

Eur J Immunol
Nakawesi J, Sow Tao Min T, Johansson C.
europepmc   +1 more source

Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples

Advanced Science, EarlyView.
This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen, Yi Zhang, Yu‐Jie Yan, Meng‐Ting Zhang, Jian‐Bo Chen, Yi‐Rong Jiang, Jie Wu, Hui‐Feng Wang, Jian‐Zhang Pan, Zhi‐Gang Chen, Jian Huang, Qun Fang   +11 more
wiley   +1 more source

Modular Droplet-Based Microfluidic Platform for Functional Phenotypic Screening of Natural Killer Cells. [PDF]

Small Methods
Aubermann F, Seneca S, Hofman T, Garcés-Lázaro I, Ajmail K, Daubner K, Cerwenka A, Platzman I, Spatz JP.   +8 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source