Results 271 to 280 of about 247,672 (311)

Targeting KDM3B Elicits Anti‐tumor Immunity by Alleviating SHP1–mediated STING Suppression in Triple–Negative Breast Cancer

Advanced Science, EarlyView.
P3FI–90 treatment targets KDM3B, reshapes the epigenetic landscape, and suppresses SHP1 expression, thereby activating STING–TBK1–IRF3–type I IFN signaling pathway. Consequently, CD8+ T cells are recruited to the tumor site and activated to produce IFN–γ and GZMB, leading to the killing of TNBC cells.
Xiaolong Wang, Wenhao Li, Yifei Wang, Ning Zhang, Bing Chen, Wenjing Zhao, Lijuan Wang, Dan Luo, Qifeng Yang   +8 more
wiley   +1 more source

Free sugar intake is associated with reduced proportion of circulating invariant natural killer T cells among women experiencing overweight and obesity. [PDF]

Front Immunol
Alhamawi RM, Almutawif YA, Aloufi BH, Alotaibi JF, Alharbi MF, Alsrani NM, Alinizy RM, Almutairi WS, Alaswad WA, Eid HMA, Mumena WA.   +10 more
europepmc   +1 more source

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

invariant Natural Killer T Cells Modulate the Peritoneal Macrophage Response to Polymicrobial Sepsis. [PDF]

J Surg Res
Heffernan DS, Chun TT, Monaghan SF, Chung CS, Ayala A.   +4 more
europepmc   +1 more source

Single-cell transcriptomics reveal different maturation stages and sublineage commitment of human thymic invariant natural killer T cells. [PDF]

J Leukoc Biol
Maas-Bauer K, Köhler N, Stell AV, Zwick M, Acharya S, Rensing-Ehl A, König C, Kroll J, Baker J, Koßmann S, Pradier A, Wang S, Docquier M, Lewis DB, Negrin RS, Simonetta F.   +15 more
europepmc   +1 more source

T Cell Receptor-Engaging Monoclonal Antibodies Mobilize the Anti-Tumor Functions of Invariant Natural Killer T Cells. [PDF]

Crit Rev Oncog
Das R.
europepmc   +1 more source

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Review on natural killer/T‐cell lymphoma

Hematological Oncology, 2021
Abstract Extranodal natural killer (NK)/T‐cell lymphoma (ENKTL) is strongly associated with Epstein–Barr virus (EBV) and has a high prevalence in Asian and in Central and South America. About 85% of ENKTLs derive from NK cells and 15% from T‐cells. Various factors have been implicated in the development of ENKTL.
Xiaohua He, Yan Gao, Zhiming Li, Huiqiang Huang   +3 more
openaire   +2 more sources

Natural killer and natural killer-T cells in psoriasis

Archives of Dermatological Research, 2002
Psoriasis is characterized by a dermal and epidermal infiltrate comprised predominantly of CD4(+) and CD8(+) T cells, respectively. These cells behave in an antigen-dependent manner, which suggests that psoriasis may be a T-cell-mediated autoimmune disease.
Cameron, A., Kirby, B., Fei, W., Griffiths, C.   +3 more
openaire   +3 more sources

Glycolipids for natural killer T cells

Chemical Society Reviews, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Paul B, Savage, Luc, Teyton, Albert, Bendelac   +2 more
openaire   +2 more sources

Natural killer T cells and haemopoiesis

British Journal of Haematology, 2006
SummaryInvariant natural killer T (iNKT) cells are a small but powerful subset of regulatory T cells involved in the modulation of a variety of normal and pathological immune responses. In contrast to conventional or other types of regulatory T cells, they are activated by glycolipid and phospholipid ligands that are presented to them by the non ...
Anastasios, Karadimitris, Scott, Patterson, Emmanouil, Spanoudakis   +2 more
openaire   +2 more sources