Results 111 to 120 of about 230,055 (317)

Highly activated and expanded natural killer cells for multiple myeloma immunotherapy

Haematologica, 2012
Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound ...
Tarun K. Garg, Susann M. Szmania, Junaid A. Khan, Antje Hoering, Paul A. Malbrough, Amberly Moreno-Bost, Amy D. Greenway, Joshuah D. Lingo, Xin Li, Shmuel Yaccoby, Larry J. Suva, Brian Storrie, Guido Tricot, Dario Campana, John D. Shaughnessy, Bijay P. Nair, William T. Bellamy, Joshua Epstein, Bart Barlogie, Frits van Rhee   +19 more
doaj   +1 more source

Unraveling Natural Killer T-Cells Development [PDF]

Frontiers in Immunology, 2018
Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell biology is needed. The first step is to learn more about NKT development within the thymus.
openaire   +3 more sources

Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells

, 2011
The outcome of viral infections is dependent on the function of CD8+ T cells which are tightly regulated by costimulatory molecules. The NK cell receptor 2B4 (CD244) is a transmembrane protein belonging to the Ig superfamily which can also be expressed ...
Lunemann, Sebastian, Bektas, Hueseyin, Heiner Wedemeyer, Wedemeyer Heiner, Suneetha, Pothakamuri Venkata, Grabowski, Jan, Michael Peter Manns, Markus Cornberg, Sarrazin, Christoph, Julia Dietz, Hueseyin Bektas, Christoph Sarrazin, Helfritz Fabian, Schlaphoff, Verena, Lunemann Sebastian, Fabian Helfritz, Suneetha Pothakamuri Venkata, Dietz, Julia, Jaroszewicz, Jerzy, Wedemeyer, Heiner, Bektas Hueseyin, Sebastian Lunemann, Pothakamuri Venkata Suneetha, Sarrazin Christoph, Manns Michael Peter, Jaroszewicz Jerzy, Jerzy Jaroszewicz, Helfritz, Fabian Arnold, Cornberg, Markus, Jan Grabowski, Schlaphoff Verena, Dietz Julia, Manns, Michael P., Verena Schlaphoff, Grabowski Jan, Cornberg Markus   +35 more
core   +1 more source

Uterine NK cells are critical in shaping DC immunogenic functions compatible with pregnancy progression. [PDF]

, 2012
Dendritic cell (DC) and natural killer (NK) cell interactions are important for the regulation of innate and adaptive immunity, but their relevance during early pregnancy remains elusive.
Irene Tirado-González, Gabriela Barrientos, Winterhager Elke, Barrientos Gabriela, Petra von Kwiatkowski (130217), Victor L. J. L. Thijssen (130213), Petra von Kwiatkowski, Burghard F. Klapp (130219), Blois, Sandra M., von Kwiatkowski, P., von Kwiatkowski Petra, Gabriela Barrientos (130201), Irene Tirado González (130195), González, I.T., Petra Moschansky (130215), Freitag, Nancy, Victor L J L Thijssen, Elke Winterhager (130222), González Irene Tirado, Klapp, Burghard F., Petra Moschansky, Freitag, N., Teresa Otto (130209), Tirado González, Irene, Nancy Freitag (130205), Gonzalez, Irene T., Barrientos, Gabriela, Bauersachs, Stefan, Nancy Freitag, Blois, S.M., Elke Winterhager, von Kwiatkowski, Petra, Thijssen, V.L.J.L., Freitag Nancy, Kwiatkowski, Petra von, Winterhager, E., Thijssen Victor L. J. L., Stefan Bauersachs (130224), Sandra M. Blois (130225), Bauersachs Stefan, Otto Teresa, Klapp, B.F., Moschansky, P., Stefan Bauersachs, Moschansky Petra, Thijssen, Victor L., Bauersachs, S., Teresa Otto, Klapp Burghard F., Barrientos, G., Burghard F Klapp, Barrientos, Gabriela Laura, Winterhager, Elke, Thijssen, Victor L. J. L., Moschansky, Petra, Otto, Teresa, Otto, T., Blois Sandra M., Sandra M Blois   +58 more
core   +1 more source

Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles

Advanced Materials, EarlyView.
This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen, Xiaoyu Wang, Jilin Fan, Bi Wang, Hanghang Fang, Yurui Wang, Hao Cui, Mohammad Roufarshbaf, Ekaterina Savina, Alexandra Valeske, Quim Peña, Yang Shi, Andreas Herrmann, Twan Lammers, Mathias Hornef, Roman Barmin, Thomas Lisson, Georg Schmitz, Anne Rix, Fabian Kiessling   +19 more
wiley   +1 more source

Machine learning and experimental validation identified autophagy signature in hepatic fibrosis

Frontiers in Immunology
BackgroundThe molecular mechanisms of hepatic fibrosis (HF), closely related to autophagy, remain unclear. This study aimed to investigate autophagy characteristics in HF.MethodsGene expression profiles (GSE6764, GSE49541 and GSE84044) were downloaded ...
Yushen Huang, Wen Luo, Zhijie Yang, Tian Lan, Xiaomou Wei, Hongwen Wu   +5 more
doaj   +1 more source

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

Frontiers in Immunology, 2018
Natural killer cell receptors (NKRs) are germline-encoded transmembrane proteins that regulate the activation and homeostasis of NK cells as well as other lymphocytes.
Bruno Silva-Santos, Jessica Strid
doaj   +1 more source

Soft, Degradable, and Magnetic Microcarriers for Encapsulation and Guided Transport of Drugs and 3D Spheroids

Advanced Materials, EarlyView.
This work presents soft, degradable hydrogel microcarriers that combine magnetic responsiveness with the ability to host multiple therapeutic and cellular components. Produced by droplet microfluidics, the carriers maintain structural integrity during manipulation, permit controlled breakdown under physiological conditions, and enable guided motion for
Xuan Peng, Lulu Song, Daryna Mruga, Veronika Bakhmat, Sergei Dzyadevych, Lin Guo, Shahrukh Shakeel, Rico Illing, Olha Bezsmertna, Xiaotao Wang, Nicholas R. Posselli, Sarthak Misra, Sandra Hauser, Jens Pietzsch, Klaus Kopka, Denys Makarov, Željko Janićijević, Xinne Zhao, Larysa Baraban   +18 more
wiley   +1 more source

Intravital imaging – dynamic insights into Natural Killer T cell biology

Frontiers in Immunology, 2015
Natural killer T (NKT) cells were first recognized more than two decades ago as a separate and distinct lymphocyte lineage that modulates an expansive range of immune responses.
Pei Xiong Liew, Paul eKubes
doaj   +1 more source

Immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients

, 2013
Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients
Lehrnbecher, Thomas, Thomas eLehrnbecher, Schmidt, Stanislaw, Thomas eKlingebiel, Tramsen, Lars, Lars eTramsen, Klingebiel, Thomas, Stanislaw eSchmidt   +7 more
core   +1 more source