Results 11 to 20 of about 230,055 (317)

Combined immune checkpoint blockade and radiotherapy induces durable remission in relapsed natural killer/T-cell lymphoma: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background Extranodal natural killer/T-cell lymphoma is a rare, aggressive non-Hodgkin lymphoma that is treated upfront mostly with L-asparaginase containing regimens. Relapsed extranodal natural killer/T-cell lymphoma is associated with a poor prognosis,
Elizabeth McGehee, Hetalkumari Patel, Caroline Pearson, Keri Clements, Jesse Manuel Jaso, Weina Chen, Alexandra Callan, Neil Desai, Praveen Ramakrishnan Geethakumari   +8 more
doaj   +1 more source

Impact of NKG2D Signaling on Natural Killer and T‐Cell Function in Cerebral Ischemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Typically defined as a thromboinflammatory disease, ischemic stroke features early and delayed inflammatory responses, which determine the extent of ischemia‐related brain damage.
Christina David, Tobias Ruck, Leoni Rolfes, Stine Mencl, Peter Kraft, Michael K. Schuhmann, Christina B. Schroeter, Robin Jansen, Friederike Langhauser, Anne K. Mausberg, Anke C. Fender, Sven G. Meuth, Christoph Kleinschnitz   +12 more
doaj   +1 more source

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Natural killer cells promote early CD8 T cell responses against cytomegalovirus. [PDF]

, 2007
Understanding the mechanisms that help promote protective immune responses to pathogens is a major challenge in biomedical research and an important goal for the design of innovative therapeutic or vaccination strategies.
Sacher, Torsten, Ulrich H Koszinowski, Rupp Brigitte, Eric Vivier, Ruzsics, Zsolt, Koszinowski Ulrich H, Cornillon, Amélie, Dalod Marc, Bessou Gilles, Koszinowski, Ulrich H, Marc Dalod, Sacher Torsten, Robbins, Scott H., Torsten Sacher, Tomasello Elena, Dalod, Marc, Scott H Robbins, Nicolas Zucchini, Ruzsics Zsolt, Koszinowski, Ulrich H., Zsolt Ruzsics, Elena Tomasello, Gilles Bessou, Bessou, Gilles, Tomasello, Elena, Cornillon Amélie, Vivier Eric, Vivier, Eric, Zucchini, Nicolas, Amélie Cornillon, Brigitte Rupp, Zucchini Nicolas, Robbins, Scott H, Robbins Scott H, Rupp, Brigitte   +34 more
core   +1 more source

Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells

Haematologica, 2014
The etiology of chronic large granular lymphocyte proliferations is largely unknown. Although these disorders are characterized by the expansion of different cell types (T and natural killer) with specific genetic features and abnormalities, several ...
Cristina Gattazzo, Antonella Teramo, Francesca Passeri, Elena De March, Samuela Carraro, Valentina Trimarco, Federica Frezzato, Tamara Berno, Gregorio Barilà, Veronica Martini, Francesco Piazza, Livio Trentin, Monica Facco, Gianpietro Semenzato, Renato Zambello   +14 more
doaj   +1 more source

Natural Killer T Cell Diversity and Immunotherapy

Cancers, 2023
Invariant natural killer T cells (iNKTs), a type of unconventional T cells, share features with NK cells and have an invariant T cell receptor (TCR), which recognizes lipid antigens loaded on CD1d molecules, a major histocompatibility complex class I (MHC-I)-like protein.
Eduardo I. Tognarelli, Cristián Gutiérrez-Vera, Pablo A. Palacios, Ignacio A. Pasten-Ferrada, Fernanda Aguirre-Muñoz, Daniel A. Cornejo, Pablo A. González, Leandro J. Carreño   +7 more
openaire   +2 more sources

Whole transcriptome analysis reveals dysregulated oncogenic lncRNAs in natural killer/T-cell lymphoma and establishes MIR155HG as a target of PRDM1

Tumor Biology, 2017
Natural killer/T-cell lymphoma is a rare but aggressive neoplasm with poor prognosis. Despite previous reports that showed potential tumor suppressors, such as PRDM1 or oncogenes associated with the etiology of this malignancy, the role of long non ...
Esra Baytak, Qiang Gong, Burcu Akman, Hongling Yuan, Wing C Chan, Can Küçük   +5 more
doaj   +1 more source

Activation of natural killer cells during microbial infections. [PDF]

, 2011
Natural killer (NK) cells are large granular lymphocytes that express a diverse array of germline encoded inhibitory and activating receptors for MHC Class I and Class I-like molecules, classical co-stimulatory ligands, and cytokines.
Riley, Eleanor M, Eleanor M Riley, Amir eHorowitz, Horowitz, Amir, Stegmann, Kerstin A, Kerstin eStegmann, Amir Horowitz, Eleanor M. Riley, Kerstin A. Stegmann   +8 more
core   +1 more source

Natural Killer/T cell primary extranasal ileum lymphoma

Revista Peruana de Medicina Experimental y Salud Pública, 2020
Primary extranodal Natural Killer / T cell lymphoma (NKTL) on gastrointestinal tract is an uncommon and aggressive neoplasm. We present the case of a 51-year-old immunocompetent patient with a 2-month history of abdominal pain.
Rita López-Cabanillas, Cristian Espinoza-Escudero, Ademir Janampa-Apaza, Rolig Aliaga-Chávez   +3 more
doaj   +1 more source

Natural killer or natural killer/T cell lineage large granular lymphocytosis associated with dasatinib therapy for Philadelphia chromosome positive leukemia

Haematologica, 2009
Dasatinib, a dual tyrosine kinase inhibitor, is known to modulate or suppress T-cell activation and proliferation. We report a series of 8 patients who developed chronic peripheral lymphocytosis, identified as natural killer cells or natural killer/T ...
Dong Hwan Kim, Suzanne Kamel-Reid, Hong Chang, Robert Sutherland, Chul Won Jung, Hyeoung-Joon Kim, Je-Jung Lee, Jeffrey H. Lipton   +7 more
doaj   +1 more source