Results 21 to 30 of about 213,838 (267)

Linking inflammation to natural killer T cell activation.

PLoS Biology, 2009
Immune activation is often associated with inflammation, but inflammation's role in the expansion of antigen-specific immune responses remains unclear. This primer focuses on recent findings that show how specific natural killer T cells are activated by ...
Mariolina Salio, Vincenzo Cerundolo
doaj   +1 more source

Natural Killer T Cell Based Immunotherapy [PDF]

Journal of Vaccines & Vaccination, 2012
Natural killer T (NKT) cells play an important immunoregulatory role and are thought to bridge the innate and adaptive immune responses. Following activation through cognate interactions with lipid antigen presented in the context of CD1d molecules, NKT cells rapidly produce a plethora of cytokines and can also mediate cytotoxicity. Due to their potent
Priyanka B, Subrahmanyam, Wenji, Sun, James E, East, Junxin, Li, Tonya J, Webb   +4 more
openaire   +2 more sources

Chemorefractory extranodal nasal-type natural-killer/T-cell lymphoma with great response to pembrolizumab in a young patient: a case report

Journal of Medical Case Reports, 2021
Introduction Extranodal, natural-killer/T-cell lymphoma of nasal type is a rare but aggressive disease usually presenting as progressive necrotic lesions in the nasal cavity that responds poorly to chemotherapy.
Fatemeh Adabifirouzjaei, Bharam Khazai, Ghazaleh Azami, Ghazaleh Shoja-e-Razavi   +3 more
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Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

PLoS ONE, 2019
Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka, Tsutomu Nakazawa, Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Koji Omoto, Yoichi Shida, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Hiromichi Morita, Takahiro Tsujimura, Hiroyuki Nakase   +12 more
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Dynamic Natural Killer Cell and T Cell Responses to Influenza Infection

Frontiers in Cellular and Infection Microbiology, 2020
Influenza viruses have perplexed scientists for over a hundred years. Yearly vaccines limit their spread, but they do not prevent all infections. Therapeutic treatments for those experiencing severe infection are limited; further advances are held back ...
Kayla Frank, Kayla Frank, Silke Paust, Silke Paust   +3 more
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Natural killer T cells and the regulation of asthma [PDF]

Mucosal Immunology, 2009
A crucial role has been suggested for invariant natural killer T cells (iNKT) in regulating the development of asthma, a complex and heterogeneous disease characterized by airway inflammation and airway hyperreactivity (AHR). iNKT cells constitute a unique subset of T cells responding to endogenous and exogenous lipid antigens, rapidly secreting a ...
P, Matangkasombut, M, Pichavant, R H, Dekruyff, D T, Umetsu   +3 more
openaire   +2 more sources

Reconstitution of natural killer cell receptors influences natural killer activity and relapse rate after haploidentical transplantation of T- and B-cell depleted grafts in children

Haematologica, 2010
Background Natural killer cells have been demonstrated to exert remarkable graft-versus-leukemia effects after haploidentical transplantation. Acquisition of both, inhibiting and activating, receptors on developing natural killer cells is an important ...
Matthias M. Pfeiffer, Tobias Feuchtinger, Heiko-Manuel Teltschik, Michael Schumm, Ingo Müller, Rupert Handgretinger, Peter Lang   +6 more
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Frequent Mutations in Natural Killer/T Cell Lymphoma

Cellular Physiology and Biochemistry, 2018
Extranodal natural killer (NK)/T cell lymphoma (ENKTL-NT or NKTCL), with its aggressive nature and poor prognosis, has been widely studied to discover more effective treatment options.
Yanjie Zhang, Chaoping Li, Weili Xue, Mingzhi Zhang, Zhaoming Li   +4 more
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Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster. [PDF]

PLoS ONE, 2018
The pathogenesis of herpes zoster is closely linked to reduced varicella-zoster virus-specific cell-mediated immunity. However, little is known about the interplay between natural killer cells and psychological stress in the pathogenesis of herpes zoster.
Choon Kwan Kim, Youn Mi Choi, Eunsin Bae, Mihn Sook Jue, Hyung Seok So, Eung-Soo Hwang   +5 more
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Extranodal Natural-Killer/T-Cell Lymphoma, Nasal Type

Advances in Hematology, 2010
The World Health Organization (WHO) classification recognizes 2 main categories of natural killer (NK) cell-derived neoplasms, namely, extranodal NK/T-cell lymphoma, nasal type, and aggressive NK-cell leukaemia.
Harinder Gill, Raymond H. S. Liang, Eric Tse   +2 more
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