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Tumor Biology, 2017 Natural killer/T-cell lymphoma is a rare but aggressive neoplasm with poor prognosis. Despite previous reports that showed potential tumor suppressors, such as PRDM1 or oncogenes associated with the etiology of this malignancy, the role of long non ...
Esra Baytak +5 more
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Activation of natural killer cells during microbial infections. [PDF]
, 2011 Natural killer (NK) cells are large granular lymphocytes that express a diverse array of germline encoded inhibitory and activating receptors for MHC Class I and Class I-like molecules, classical co-stimulatory ligands, and cytokines.
Riley, Eleanor M +8 more
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Natural Killer/T cell primary extranasal ileum lymphoma
Revista Peruana de Medicina Experimental y Salud Pública, 2020 Primary extranodal Natural Killer / T cell lymphoma (NKTL) on gastrointestinal tract is an uncommon and aggressive neoplasm. We present the case of a 51-year-old immunocompetent patient with a 2-month history of abdominal pain.
Rita López-Cabanillas +3 more
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Haematologica, 2009 Dasatinib, a dual tyrosine kinase inhibitor, is known to modulate or suppress T-cell activation and proliferation. We report a series of 8 patients who developed chronic peripheral lymphocytosis, identified as natural killer cells or natural killer/T ...
Dong Hwan Kim +7 more
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Natural killer and natural killer T cells in liver fibrosis
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013 The liver lymphocyte population is enriched with natural killer (NK) cells, which play a key role in host defense against viral infection and tumor transformation. Recent evidence from animal models suggests that NK cells also play an important role in inhibiting liver fibrosis by selectively killing early or senescence activated hepatic stellate cells
Gao, Bin, Radaeva, Svetlana
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Immunoregulation of Autoimmunity by Natural Killer T Cells [PDF]
Human Immunology, 2005 Natural killer T (NKT) cells are a conserved subpopulation of lymphocytes that recognize glycolipid antigens in a CD1d context. Upon activation through their semi-invariant T cell receptor, these cells rapidly release large amounts of immunomodulating Th1 and Th2 cytokines.
Loes, Linsen +2 more
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Linking inflammation to natural killer T cell activation.
PLoS Biology, 2009 Immune activation is often associated with inflammation, but inflammation's role in the expansion of antigen-specific immune responses remains unclear. This primer focuses on recent findings that show how specific natural killer T cells are activated by ...
Mariolina Salio, Vincenzo Cerundolo
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Journal of Medical Case Reports, 2021 Introduction Extranodal, natural-killer/T-cell lymphoma of nasal type is a rare but aggressive disease usually presenting as progressive necrotic lesions in the nasal cavity that responds poorly to chemotherapy.
Fatemeh Adabifirouzjaei +3 more
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PLoS ONE, 2019 Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka +12 more
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Natural killer T cells in health and disease [PDF]
Frontiers in Bioscience, 2011 Natural killer T (NKT) cells are a subset of T lymphocytes that share surface markers and functional characteristics with both conventional T lymphocytes and natural killer cells. Most NKT cells express a semi-invariant T cell receptor that reacts with glycolipid antigens presented by the major histocompatibility complex class I-related protein CD1d on
Lan, Wu, Luc, Van Kaer
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