Results 41 to 50 of about 224,959 (265)

Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer

BMC Cancer, 2018
Background Salivary gland cancers are not sensitive to conventional radiotherapy or chemotherapy regimens. Therefore, the development of a new treatment strategy is of critical importance for improving the prognosis.
Yuji Makita, Naoki Kunii, Daiju Sakurai, Fumie Ihara, Shinichiro Motohashi, Akane Suzuki, Toshinori Nakayama, Yoshitaka Okamoto   +7 more
doaj   +1 more source

Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer

Nature Communications, 2023
Numerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous factors that dampen the immune response, including viruses like human immunodeficiency virus.
Jose M. Ayuso, Mehtab Farooqui, María Virumbrales-Muñoz, Katheryn Denecke, Shujah Rehman, Rebecca Schmitz, Jorge F. Guerrero, Cristina Sanchez-de-Diego, Sara Abizanda Campo, Elizabeth M. Maly, Matthew H. Forsberg, Sheena C. Kerr, Robert Striker, Nathan M. Sherer, Paul M. Harari, Christian M. Capitini, Melissa C. Skala, David J. Beebe   +17 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Pancreas Involvement of Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type, Presenting as Acute Pancreatitis: A Case Report

Medicina, 2022
Background: The main etiology of acute pancreatitis includes biliary origin and alcohol, although various other causes include drugs (i.e., L-asparaginase) or malignant tumors.
Dong Wook Lee, Yun Jeong Kim, Chang Min Cho   +2 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Development of human T and natural killer cells [PDF]

Blood, 1995
ELLS BELONGING to the lymphoid lineages are instrumental in protecting their hosts against an enormous diversity of foreign agents. Of these, T and B cells are most extensively studied. The way these cells recognize foreign antigens through the T-cell receptor (TCR) and Igs is now well understood.
H, Spits, L L, Lanier, J H, Phillips
openaire   +2 more sources

Synchronous primary pulmonary extranodal NK/T-cell lymphoma and relapsed Hodgkin lymphoma occurring after chemotherapy for primary Hodgkin lymphoma: A case report and literature review

Rare Tumors
Extranodal natural killer/T-cell lymphoma is a rare and aggressive malignancy with a predilection for Asian and Latin American populations. While typically presenting in the nasal cavity, extranasal forms—particularly primary pulmonary extranodal natural
David Corredor-Orlandelli, Leonardo Bohórquez, Mónica Arévalo-Zambrano   +2 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Development of invariant natural killer T cells [PDF]

Current Opinion in Immunology, 2016
Invariant natural killer T (iNKT) cells develop into functionally distinct subsets. Each subset expresses a unique combination of transcription factors that regulate cytokine gene transcription upon activation. The tissue distribution and localization within tissues also varies between subsets. Importantly, the relative abundance of the various subsets
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source