Results 71 to 80 of about 323,886 (359)

Non-coding RNAs in Natural Killer/T-Cell Lymphoma

Frontiers in Oncology, 2019
Natural killer/T-cell lymphoma (NKTCL) is a rare and aggressive subtype of non-Hodgkin's lymphoma that is associated with a poor outcome. Non-coding RNAs (ncRNAs), which account for 98% of human RNAs, lack the function of encoding proteins but instead ...
Mei Mei, Mei Mei, Mingzhi Zhang
doaj   +1 more source

Clinical and immunological characteristics for BK polyomavirus‐associated nephropathy after kidney transplantation

Immunity, Inflammation and Disease, 2023
Introduction BK polyomavirus (BKPyV)‐associated nephropathy (BKPyVAN) can cause a significant risk of allograft impairment after kidney transplantation (KT). Intact BKPyV‐specific immunity is associated with viral containment.
Tanaya Siripoon, Nopporn Apiwattanakul, Pannawat Mongkolrattanakul, Chutatip Tongsook, Nattawut Unwanatham, Suradej Hongeng, Surasak Kantachuvesiri, Jackrapong Bruminhent   +7 more
doaj   +1 more source

Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens

Nature Communications, 2016
Crucial to Natural Killer T (NKT) cell function is the interaction between their T-cell receptor (TCR) and CD1d-antigen complex. However, the diversity of the NKT cell repertoire and the ensuing interactions with CD1d-antigen remain unclear.
J. L. Nours, J. L. Nours, T. Praveena, D. Pellicci, D. Pellicci, N. Gherardin, N. Gherardin, F. Ross, F. Ross, R. T. Lim, G. Besra, Santosh Keshipeddy, S. Richardson, A. Howell, S. Gras, S. Gras, D. Godfrey, D. Godfrey, J. Rossjohn, J. Rossjohn, J. Rossjohn, Adam P. Uldrich, Adam P. Uldrich   +22 more
semanticscholar   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Nasal-Type Natural Killer/T-Cell Extranodal Lymphoma

Sinusitis
Nasal-type extranodal natural killer/T-cell lymphoma (ENKTL) is a rare, aggressive non-Hodgkin lymphoma associated with the Epstein–Barr virus (EBV). It predominantly affects middle-aged men and is most common in East Asia and Latin America.
Mustapha Sellami, Sofiane Amazigh Akbal, Lycia Zaidi, Abderrahmane Akacha   +3 more
doaj   +1 more source

LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells [PDF]

, 2022
Ho Ngai, Gabriel A. Barragán, Gengwen Tian, Julien Balzeau, Chunchao Zhang, Amy N. Courtney, Linjie Guo, Xin Xu, Michael S. Wood, Janice M. Drabek, Thorsten Demberg, Caroline M. Sands, Cynthia Chauvin, Erica J. Di Pierro, Jeffrey M. Rosen, Leonid S. Metelitsa   +15 more
openalex   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Epstein-Barr Virus-Positive Natural Killer/T-Cell Lymphoma

Frontiers in Oncology, 2019
Extranodal natural killer/T-cell lymphoma, nasal type (ENKL), is a rare malignancy of Non-Hodgkin lymphoma characterized by an aggressive clinical course and poor prognosis.
Qingqing Cai, Qingqing Cai, Jun Cai, Jun Cai, Yu Fang, Yu Fang, Ken H. Young   +6 more
doaj   +1 more source

Natural Killer T Cell–Based Cancer Immunotherapy [PDF]

Clinical Cancer Research, 2006
In this issue of Clinical Cancer Research , Motohashi et al. ([1][1]) present data on the first clinical trial using adoptive transfer of invariant natural killer T (iNKT) cells in patients with advanced or recurrent non–small cell lung cancer.
Hans J J, van der Vliet, Steven P, Balk, Mark A, Exley   +2 more
openaire   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source