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Targeting Natural Killer T Cells in Solid Malignancies [PDF]
Cells, 2021 Natural killer T (NKT) cells are a unique subset of lymphocytes that recognize lipid antigens in the context of the non-classical class I MHC molecule, CD1d, and serve as a link between the innate and adaptive immune system through their expeditious ...
Zewde Ingram +6 more
doaj +2 more sources
Invariant natural killer T cells in lung diseases [PDF]
Experimental and Molecular Medicine, 2023 Invariant natural killer T (iNKT) cells are a subset of T cells that are characterized by a restricted T-cell receptor (TCR) repertoire and a unique ability to recognize glycolipid antigens.
Dongjin Jeong +2 more
doaj +2 more sources
Natural killer cells and natural killer T cells in Lyme arthritis [PDF]
Arthritis Research & Therapy, 2013 Introduction: Natural killer (NK) and natural killer T (NKT) cells provide a first line of defense against infection. However, these cells have not yet been examined in patients with Lyme arthritis, a late disease manifestation.
Drouin, Elise E +2 more
core +6 more sources
Haematologica, 2009 Dasatinib, a dual tyrosine kinase inhibitor, is known to modulate or suppress T-cell activation and proliferation. We report a series of 8 patients who developed chronic peripheral lymphocytosis, identified as natural killer cells or natural killer/T ...
Dong Hwan Kim +7 more
doaj +3 more sources
Unraveling Natural Killer T-Cells Development [PDF]
Frontiers in Immunology, 2018 Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
doaj +3 more sources
Immunometabolic Activation of Invariant Natural Killer T Cells [PDF]
Frontiers in Immunology, 2018 Invariant natural killer T (iNKT) cells are lipid-reactive T cells with profound immunomodulatory potential. They are unique in their restriction to lipid antigens presented in CD1d molecules, which underlies their role in lipid-driven disorders such as ...
Francesca A. Ververs +7 more
doaj +2 more sources
LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells. [PDF]
Cancer Immunol Res, 2023 Ngai H +15 more
europepmc +3 more sources
Skin TLR7 triggering promotes accumulation of respiratory dendritic cells and natural killer cells. [PDF]
, 2012 The TLR7 agonist imiquimod has been used successfully as adjuvant for skin treatment of virus-associated warts and basal cell carcinoma. The effects of skin TLR7 triggering on respiratory leukocyte populations are unknown.
Baal, Nelli +9 more
core +14 more sources
Tissue-specific functions of invariant natural killer T cells
Nature Reviews Immunology, 2018 Catherine M Crosby, Mitchell Kronenberg
exaly +3 more sources
Natural killer T cells (NK T cells) functions in malignancies
Asian Pacific Journal of Cancer Biology, 2018 CD1d-restricted natural killer (NKT) cells are unique innate like T lymphocyte that recognize glycolipid antigens. Two major NKT cell subsets, type I and type II, are different in their TCR repertoire and ligand specificity.
Sima balouchi-anaraki, Marzie Norouzian
doaj +3 more sources