Results 11 to 20 of about 366,560 (304)
Natural Killer T Cell Based Immunotherapy [PDF]
Journal of Vaccines & Vaccination, 2012 Natural killer T (NKT) cells play an important immunoregulatory role and are thought to bridge the innate and adaptive immune responses. Following activation through cognate interactions with lipid antigen presented in the context of CD1d molecules, NKT cells rapidly produce a plethora of cytokines and can also mediate cytotoxicity. Due to their potent
Priyanka B, Subrahmanyam +4 more
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Natural killer T cells: Know thyself [PDF]
Proceedings of the National Academy of Sciences, 2007 There are two main reasons why natural killer T (NKT) cells fascinate immunologists. First, they exhibit a unique melange of properties found in innate immune cells as well as the properties of conventional T cells, part of adaptive immunity (1–4). Second, NKT cells exercise a determining influence on a variety of immune responses in mice, ranging from
Mitchell, Kronenberg, Laurent, Gapin
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T-cell dysfunction in natural killer/T-cell lymphoma
OncoImmunology, 2023 Natural killer/T-cell lymphoma (NKTCL) is an incurable aggressive T-cell lymphoma closely correlated with Epstein‒Barr virus (EBV) infection. Chronic and consistent viral infection induces T-cell exhaustion. Herein, we describe T-cell dysfunction in NKTCL patients for the first time.
Xiaoyan Feng +8 more
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Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists [PDF]
, 2015 Alpha-Galactosyl Ceramide (α-GalCer) is a prototypical synthetic ligand of invariant natural killer T (iNKT) cells. Upon presentation by the MHC class I-like molecule CD1d, this glycolipid stimulates iNKT cells to secrete a vast amount of both pro ...
ASPESLAGH, SANDRINE +5 more
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ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]
, 2020 CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun +12 more
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Nasal Natural Killer/T Cell Lymphoma [PDF]
Indian Journal of Hematology and Blood Transfusion, 2014 Nasal natural killer/T cell lymphomas are locally destructive mid-facial necrotizing lesions. It is an uncommon disease but, usually shows a highly aggressive clinical course. Amongst the sino-nasal lymphomas, it is the most common type. The non-specific clinical features constitute a major stumbling block in the early diagnosis and management of these
Milind Anil, Bhatkule +3 more
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مجله دانشکده پزشکی اصفهان, 2018 Background: Unexplained recurrent spontaneous abortion (URSA) is the most common immunological complication during pregnancy. The evidence of in-vitro assays has shown that immune cells are responsible for embryotoxicity.
Fahimeh Khadem +3 more
doaj +1 more source
Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]
, 2017 Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura +17 more
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Natural Killer T Cells in Cancer Immunotherapy
Frontiers in Immunology, 2017 Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment.
Shiny Nair, Madhav V. Dhodapkar
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