Results 101 to 110 of about 371,435 (345)

Working in “NK Mode”: Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by γδ T Cells

Frontiers in Immunology, 2018
Natural killer cell receptors (NKRs) are germline-encoded transmembrane proteins that regulate the activation and homeostasis of NK cells as well as other lymphocytes.
Bruno Silva-Santos, Jessica Strid
doaj   +1 more source

Olink Proteomics Analysis Reveals Heterogeneous Responses to FcRn Blockade in Anti‐AChR Antibody‐Positive Myasthenia Gravis: FGF‐19 as a Novel Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo, Deyou Peng, Zhouao Zhang, Mingjin Yang, Xinyan Guo, Tianyu Ma, Xiaoyu Huang, Mingming Xu, Linlin Fu, Yong Zhang   +9 more
wiley   +1 more source

Favorable impact of natural killer cell reconstitution on chronic graft-versus-host disease and cytomegalovirus reactivation after allogeneic hematopoietic stem cell transplantation

Haematologica, 2014
Natural killer cells are the first lymphocyte subset to reconstitute, and play a major role in early immunity after allogeneic hematopoietic stem cell transplantation.
Vissal David Kheav, Marc Busson, Catherine Scieux, Régis Peffault de Latour, Guitta Maki, Philippe Haas, Marie-Christine Mazeron, Maryvonnick Carmagnat, Emeline Masson, Aliénor Xhaard, Marie Robin, Patricia Ribaud, Nicolas Dulphy, Pascale Loiseau, Dominique Charron, Gérard Socié, Antoine Toubert, Hélène Moins-Teisserenc   +17 more
doaj   +1 more source

The immune cell landscape in kidneys of patients with lupus nephritis. [PDF]

, 2019
Lupus nephritis is a potentially fatal autoimmune disease for which the current treatment is ineffective and often toxic. To develop mechanistic hypotheses of disease, we analyzed kidney samples from patients with lupus nephritis and from healthy control
Accelerating Medicines Partnership in SLE network, Anolik, Jennifer H, Apruzzese, William, Arazi, Arnon, Berthier, Celine C, Brenner, Michael B, Browne, Edward P, Buyon, Jill P, Chicoine, Adam, Dall'Era, Maria, Davidson, Anne, Diamond, Betty, Eisenhaure, Thomas M, Furie, Richard A, Hacohen, Nir, Hildeman, David A, Hoover, Paul J, Jonsson, A Helena, Kalunian, Kenneth C, Kamen, Diane L, Kretzler, Matthias, Lederer, James A, Li, Shuqiang, Lieb, David J, Liu, Yanyan, Massarotti, Elena, McInnis, Elizabeth A, Noma, Akiko, Nusbaum, Chad, Park, Meyeon, Payan-Schober, Fernanda, Pendergraft, William F, Petri, Michelle A, Putterman, Chaim, Rao, Deepak A, Raychaudhuri, Soumya, Slowikowski, Kamil, Smilek, Dawn E, Steelman, Scott, Sutherby, Danielle, Tosta, Patti, Wofsy, David, Woodle, E Steve, Zhang, Fan   +43 more
core  

Revving up natural killer cells and cytokine-induced killer cells against hematological malignancies [PDF]

, 2015
Natural killer (NK) cells belong to innate immunity and exhibit cytolytic activity against infectious pathogens and tumor cells. NK-cell function is finely tuned by receptors that transduce inhibitory or activating signals, such as killer immunoglobulin ...
Alici, Alnabhan, Aversa, Bachanova, Bachanova, Bachanova, Benjamin, Benson, Benyunes, Berg, Berg, Bertaina, Betters, Biassoni, Biassoni, Bonanno, Bonanno, Braud, Burns, Burshtyn, Burshtyn, Caligiuri, Caligiuri, Campbell, Campbell, Cany, Carlens, Cheng, Cheng, Cho, Chouaib, Chu, Colonna, Conlon, Cooley, Cooley, Cosman, Curti, Denman, Durrieu, D’Andrea, Edinger, Escudier, Farag, Fehniger, Frei, Frohn, Fry, Fujisaki, Fujisaki, Garg, Gleason, Gleason, Glienke, Gong, Grimm, Gumperz, Guven, Hercend, Hontscha, Imai, Imamura, Introna, Introna, Introna, Iyengar, Jiang, Jiang, Jiang, Karlhofer, Karre, Kim, Kim, Klingemann, Klingemann, Klingemann, Knorr, Knorr, Koehl, Koehl, Koehl, Koepsell, Lang, Lapteva, Lee, Li, Li, Lim, Lim, Linn, Lister, Litwin, Liu, Ljunggren, Llano, Lotze, Lu, Luhm, Lundqvist, Lundqvist, Lundqvist, Mackall, Maus, McKenna, Meehan, Meyer-Monard, Miller, Miller, Miller, Miller, Miller, Oevermann, Olcese, Olioso, Parkhurst, Pende, Pende, Peragine, Perussia, Phillips, Phillips, Phillips, Pittari, Pittari, Rabinowich, Rettinger, Rizzieri, Romagne, Rosenberg, Rosenberg, Rosenberg, Rubnitz, Ruggeri, Rutella, Rutella, Rutella, Rutella, Schmeel, Schmidt-Wolf, Schmidt-Wolf, Schumm, Shah, Shaim, Shi, Shimasaki, Siegler, Soiffer, Somanchi, Somanchi, Spanholtz, Stern, Stroncek, Sutlu, Sweeney, Tam, Tam, Tam, Tanaka, Tomchuck, Tonn, Venstrom, Venstrom, Verneris, Vey, Vitale, Wagtmann, Wagtmann, Wiernik, Winter, Yan, Yang, Yoon, Yron, Zhang, Zhang   +174 more
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In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Derivation of mimetic γδ T cells endowed with cancer recognition receptors from reprogrammed γδ T cell.

PLoS ONE, 2019
Using induced pluripotent stem cells (iPSCs) to derive chimeric antigen receptor-modified T (CAR-T) cells has great industrial potential. A previous study used αβ T cell-derived CAR-modified iPSCs to produce CAR-T cells.
Jieming Zeng, Shin Yi Tang, Shu Wang
doaj   +1 more source

Association of Symptomatic Human Infection with Toxoplasma gondii with Imbalance of Monocytes and Antigen-Specific T Cell Subsets [PDF]

, 2017
During recent symptomatic toxoplasmosis, alterations in quantity and function of mononuclear cellsin peripheral blood were observed. Flow cytofluorometric analysis and differential leukocyte counts revealed increasedabsolute numbers of T8 + cells, Leu 7 +
Alkan, Sefik, Erb, Peter, Jones, Thomas C., Sklenar, Ivo   +3 more
core  

Development of invariant natural killer T cells [PDF]

Current Opinion in Immunology, 2016
Invariant natural killer T (iNKT) cells develop into functionally distinct subsets. Each subset expresses a unique combination of transcription factors that regulate cytokine gene transcription upon activation. The tissue distribution and localization within tissues also varies between subsets. Importantly, the relative abundance of the various subsets
openaire   +2 more sources

Monocyte LOXHD1 and RHOB Expression Predictive of Progressive Systemic Sclerosis–Associated Interstitial Lung Disease

Arthritis Care &Research, EarlyView.
Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla, Robert Lafyatis, Kevin F. Gibson, Christina Morse, Eleanor Valenzi, Xiaoping Chen, Xiaoyun Li, Yanwu Zhao, Yongseok Park, Dana Ascherman, Jonathan Minden, Robyn Domsic, Yingze Zhang, Daniel J. Kass   +13 more
wiley   +1 more source