Results 111 to 120 of about 366,560 (304)

Lineage Differentiation Program of Invariant Natural Killer T Cells [PDF]

, 2017
Invariant natural killer T (iNKT) cells are innate T cells restricted by CD1d molecules. They are positively selected in the thymic cortex and migrate to the medullary area, in which they differentiate into 3 different lineages.
Dong-il Kwon, You Jeong Lee
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

Cell Reports, 2019
Summary: Despite the clinical success of cancer immunotherapies, the majority of patients fail to respond or develop resistance through disruption of pathways that promote neo-antigen presentation on MHC I molecules.
Andrew J. Freeman, Stephin J. Vervoort, Kelly M. Ramsbottom, Madison J. Kelly, Jessica Michie, Lizzy Pijpers, Ricky W. Johnstone, Conor J. Kearney, Jane Oliaro   +8 more
doaj   +1 more source

Kinetics and cellular site of glycolipid loading control [PDF]

, 2009
CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines.
Arora, Pooja, Baena, Andres, Baine, Ian, Bricard, Gabriel, Goldberg, Michael F., Im, Jin S., Jerud, Elliot S., Molano, Alberto, Ndonye, Rachel M., Venkataswamy, Manjunatha M., Yu, Karl O.A.   +10 more
core  

In vitro-differentiated T/natural killer-cell progenitors derived from human CD34+ cells mature in the thymus [PDF]

, 2010
Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a treatment option for patients with hematopoietic malignancies that is hampered by treatment-related morbidity and mortality, in part the result of opportunistic infections, a direct
Borsotti, C, Bos, G M, Cloosen, S, Germeraad, W T, Hesselink, R, Katsura, Y, Kawamoto, H, Leewis, B, Manz, M G, Meek, B, Schnijderberg, M C, van der Poel, M W, Van Elssen, C H, Vanderlocht, J   +13 more
core   +1 more source

Natural killer T cells in pulmonary disorders

Respiratory Medicine, 2011
Natural killer T (NKT) cells, a unique subgroup of lymphocytes with features of both T and natural killer (NK) cells, represent a bridge between innate and adaptive immunity. They have the ability to either promote or suppress immune responses. With these immunoregulatory functions, NKT cells have emerged as an important subset of lymphocytes with a ...
Rijavec, Matija, Volarevic, Sinisa, Osolnik, Katarina, Kosnik, Mitja, Korosec, Peter   +4 more
openaire   +4 more sources

Model‐Driven Optimization of Subcutaneous Polymer Prodrugs Achieves Cancer Remission in Mice

Advanced Healthcare Materials, EarlyView.
A pharmacokinetics/pharmacodynamics (PK/PD) model was developed to evaluate multiple dosing regimens for subcutaneously administered water‐soluble polymer prodrug for cancer therapy. The model enabled prediction of in vivo performance and contributed to the optimization of anticancer efficacy.
Anne Rodallec, Randy Lee, Jingming Cao, Sophie Marolleau, Julien Nicolas, Sébastien Benzekry   +5 more
wiley   +1 more source

Activation mechanisms of invariant natural killer T cells (iNKTs)

Iatreia, 2016
A great amount of knowledge on natural killer T cells (iNKTs) is now available, but a consensus about their activation mechanisms has not been reached. These cells recognize different glycolipid antigens through the CD1d molecule.
Baena, Andrés, Gómez-Giraldo, Lina, Carreño, Leandro J.   +2 more
doaj   +1 more source

The Ly49E receptor inhibits the immune control of acute Trypanosoma cruzi infection [PDF]

, 2016
The protozoan parasite Trypanosoma cruzi circulates in the blood upon infection and invades various cells. Parasites intensively multiply during the acute phase of infection and persist lifelong at low levels in tissues and blood during the chronic phase.
Almeida, Andrade, Antunez, Aune, Avilan, Bern, Cardillo, Carlier, Carnaud, Cesari, Collins, Culbertson, Dowling, Duthie, Duthie, Duthie, Filtjens, Fraser, Frosch, Gritz, Hanke, Keating, Lieke, Lieke, Mekkawy, Meyer Zum Buschenfelde, Mondino, Nagata, Nogueira, Pettengill, Pinazo, Rassi, Robertson, Rottenberg, Santana, Sardinha, Stevenaert, Taveirne, Torrico, Truyens, Truyens, Truyens, Une, Van Beneden, Van Beneden, Van Den Broeck, Van Den Broeck, Vassalli, Wen   +48 more
core   +2 more sources

Photothermal‐Activated Antibacterial Amyloid‐Polyphenol‐Iron Hydrogels for Synergistic Wound Healing

Advanced Healthcare Materials, EarlyView.
We report a thermally triggered supramolecular hydrogel (LTFe) formed by Fe3+ and tannic acid on lysozyme amyloid fibrils. Fe3+ enables rapid gelation and photothermal transduction with an efficiency of 88.56%. The LTFe hydrogel exhibits excellent biocompatibility, potent antibacterial activity against E. coli and S.
Di Wu, Jiangtao Zhou, Yang Shen, Qiyao Sun, Tong Li, Xiaoyang Zou, Bin Liu, Hongshan Liang, Raffaele Mezzenga   +8 more
wiley   +1 more source