Results 131 to 140 of about 224,756 (217)

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Stem cell engineering for the generation of allogeneic CAR-directed natural killer T cells targeting endometrial carcinoma. [PDF]

Exp Hematol Oncol
Li YR, DiBernardo GA, Chen Y, Shen X, Hon R, Ruegg LE, Huang J, Neal A, Moatamed NA, Memarzadeh S, Yang L.   +10 more
europepmc   +1 more source

Type 1 invariant natural killer T cells in chronic inflammation and tissue fibrosis. [PDF]

Front Immunol, 2023
Kumar V, Hertz M, Agro A, Byrne AJ.
europepmc   +1 more source

AHR‐Responsive Carbon Dots Orchestrate Skin Wound Healing and Colonic Mucosal Repair via Treg‐Mediated Macrophage Efferocytosis

Advanced Science, EarlyView.
Guided by pharmacophore modeling and molecular docking, aryl hydrocarbon receptor (AHR)‐responsive carbon dots were synthesized. They bind directly to AHR and expand gut‐resident regulatory T (Treg) cells. Treg‐derived C‐C motif chemokine ligand 1 (CCL1) enhances macrophage efferocytosis, creating a pro‐regenetative niche that promotes colonic mucosal ...
Zilu Zhu, Han Zhang, Shuai Lin, Wenqian Zheng, Xin Li, Xiaowei Xu, Ruili Yang   +6 more
wiley   +1 more source

IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activity. [PDF]

Mol Ther
Barragán Bravo GA, de la Cerda DA, Landoni E, Dholakia K, Humeniuk P, Caraballo Galva LD, Wang Y, Tian G, Yang B, Guo L, Wood MS, Rios X, Xu X, Courtney AN, Di Pierro EJ, Jacob J, Li YH, Adaikkalavan A, Watanabe N, Mao S, Miles G, Dotti G, Metelitsa LS.   +22 more
europepmc   +1 more source

A Metal‐Polyphenol Self‐Assembled Coated 3D Sponge With Mild Photothermal Antibacterial, Exudate‐Controlling, and Immunomodulatory Functions for Hemostasis and Chronic Wound Healing

Advanced Science, EarlyView.
A thrombin‐functionalized copper‐polydopamine nanofiber sponge integrates rapid hemostasis, mild photothermal antibacterial therapy, stimulus‐responsive Cu2+ release, chemodynamic oxidative stress, and macrophage immunomodulation. This multifunctional dressing suppresses infection, regulates inflammation, promotes angiogenesis and re‐epithelialization,
Ziwei Zhang, Feng Qin, Xiaomeng Zhang, Xueqin Shuang, Jiahua Zhou, Ming Cheng, Baicheng Lu, Mingyue Song, Yuntian Bai, Dianying Zhang, Ming Li, Yanhua Wang   +11 more
wiley   +1 more source

Dual regulatory role of natural killer T cells during development of hepatocellular carcinoma. [PDF]

Commun Biol
Papanastasatou M, Gioulbasani M, Nakou E, Galaras A, Rubio-Tomás T, Talianidis I, Eliopoulos AG, Hatzis P, Verykokakis M.   +8 more
europepmc   +1 more source

SPLENIC INVARIANT NATURAL KILLER T CELLS PLAY A SIGNIFICANT ROLE IN THE RESPONSE TO POLYMICROBIAL SEPSIS. [PDF]

Shock, 2023
Heffernan DS, Chung CS, Ayala A.
europepmc   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

<i>In vivo</i> stimulation of natural killer T cells and downstream regulatory T cells to reduce acute graft-versus-host disease. [PDF]

Ann Transl Med
Sluyter R, McErlean G.
europepmc   +1 more source