Results 141 to 150 of about 230,395 (312)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Dual-targeted CAR T-cell immunotherapies for hematological malignancies: latest updates from the 2023 ASH annual meeting

Experimental Hematology & Oncology
Over the past few years, dual-targeted chimeric antigen receptor (CAR) T-cell therapy has been employed in the management of hematological malignancies to mitigate treatment failure, particularly in cases of antigen escape.
Jingyi Yang, Hao Guo, Lu Han, Yongping Song, Keshu Zhou   +4 more
doaj   +1 more source

Characterisation of T cell defects in acute myeloid leukaemia

, 2009
PhDUnderstanding the immune system in patients with cancer and how it interacts with malignant cells is critical for the development of successful immunotherapeutic strategies at a time when novel cancer treatment approaches are required.
Le Dieu, Helen Rifca
core  

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Detection of Mouse Natural Killer T Follicular Helper (NKTFH) Cells by Flow Cytometry

, 2016
Natural killer T follicular helper (NKTFH) cell, a recently identified B-cell helper innate cell population, can be easily missed due to its low frequency and the fact that it only forms upon immunization or infection with glycolipid-containing antigens ...
Garcia De Vinuesa, Maria Carola, Chang, Pheh   +1 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Stress and Recurrent Miscarriage [PDF]

, 2010
This thesis investigated the role of stress in RM using both psychometric and biochemical measures. The majority of previous studies on the impact of stress on RM only addressed the psychological aspect without concurrent biochemical stress measurements.
Li, Wei
core  

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

IL-2 stimulated but not unstimulated NK cells induce selective disappearance of peripheral blood cells: concomitant results to a phase I/II study

, 2011
In an ongoing clinical phase I/II study, 16 pediatric patients suffering from high risk leukemia/tumors received highly purified donor natural killer (NK) cell immunotherapy (NK-DLI) at day (+3) +40 and +100 post haploidentical stem cell transplantation.
Claudia Brehm, Bader Peter, Soerensen, Jan, Klingebiel Thomas, Seidl, Christian, Christian Seidl, Petra S. A. Becker, Bremm Melanie, Koehl Ulrike, Becker, Petra S. A., Jakob R. Passweg, Sabine Huenecke, Andrea Quaiser, Peter Bader, Koehl, Ulrike, Thomas Klingebiel, Ulrike Koehl, Jakob R Passweg, Brehm Claudia, Jan Soerensen, Hermann Kreyenberg, Schwabe Dirk, Becker Petra S. A., Brehm, Claudia, Quaiser, Andrea, Petra S A Becker, Bader, Peter, Sörensen, Jan, Mühl Heiko, Stephan Kloess, Huenecke, Sabine, Mühl, Heiko, Klingebiel, Thomas, Esser Ruth, Klöß, Stephan, Esser, Ruth, Hünecke, Sabine, Kloess, Stephan, Huenecke Sabine, Kreyenberg Hermann, Seidl Christian, Melanie Bremm, Kreyenberg, Hermann, Bremm, Melanie, Heiko Mühl, Ruth Esser, Dirk Schwabe, Soerensen Jan, Köhl, Ulrike, Quaiser Andrea, Passweg, Jakob R., Schwabe, Dirk, Kloess Stephan, Passweg Jakob R.   +53 more
core   +1 more source

natural killer T cell

Citation: 'natural killer T cell' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13501 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
openaire   +1 more source