Results 201 to 210 of about 230,395 (312)

Natural Killer T Cells Link Stress Hyperglycemia to Cognitive Decline in HFpEF. [PDF]

Circ Res
Mone P, Ciccarelli M, Jankauskas SS, Picone F, Guerra G, Testa G, Moccia F, Magliuolo R, Di Mauro M, De Luca A, Carrizzo A, Vecchione C, Santulli G.   +12 more
europepmc   +1 more source

Invariant natural killer T cells and incidence of first-time coronary events: a nested case-control study. [PDF]

Eur Heart J Open, 2023
Tomas L, Katra P, Badn W, Andersson L, Nilsson J, Schiopu A, Engelbertsen D, Gonçalves I, Bengtsson E, Björkbacka H.   +9 more
europepmc   +1 more source

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Facts and Hopes of Chimeric Antigen Receptor-Redirected NK T Cells. [PDF]

Clin Cancer Res
Courtney AN, Zhou X, Tian G, Wang Y, Metelitsa LS, Dotti G.   +5 more
europepmc   +1 more source

Invariant natural killer T cells and iron metabolism orchestrate skin development and homeostasis. [PDF]

Cell Mol Immunol, 2023
Nabeshima H, Niitsu T, Fukushima K, Kida H.   +3 more
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Activation of Invariant Natural Killer T Cells Enhances Ischemia-Reperfusion Injury in Steatotic Mouse Livers. [PDF]

In Vivo
Kuroda YU, Ito Y, Nishizawa N, Tanabe M, Goto T, Yamashita A, Hosono K, Satoh M, Kumamoto Y, Hiki N, Amano H.   +10 more
europepmc   +1 more source

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury. [PDF]

iScience, 2023
Gonzatti MB, Freire BM, Antunes MM, de Menezes GB, Talbot J, Peron JPS, Basso AS, Keller AC.   +7 more
europepmc   +1 more source

Tumor‐Derived Exosomes Deliver Membrane‐Bound Fgl2 to Activate FcγRIIB‐Mediated Immunosuppression in Myeloid‐Derived Suppressor Cells

Advanced Science, EarlyView.
This study reveals that the Fgl2‐FcγRIIB signaling axis is a key mechanism by which MDSCs mediate tumor immune evasion. Tumor‐derived exosomes systemically activate MDSCs via this pathway, positioning this axis as a promising broad‐spectrum target for cancer immunotherapy.
Fenglin Lin, Dingqin Cai, Chunli Jian, Yaxian Qi, Linpeng Zheng, Qiao Yang, Longyao Zhang, Diangang Chen, Lingchen Li, Ping Cai, Lingyou Sun, Luping Zhang, Jianguo Sun   +12 more
wiley   +1 more source

Characterizing Kupffer Cell Production of CD5 Antigen-Like and Its Function on Regulating Migration of Natural Killer T Cells. [PDF]

Am J Pathol
Hong H, Tu T, Alhousari D, He L, Aggarwal R, Debebe A, Chen CY, Ashouri K, Martynova A, Nakhoul C, Rastegarpour A, Baharlouei S, Peng D, Stile EX, Razaviyayn M, Suen SC, Cadenas E, Alachkar H, Yuan W, Machida K, Tsukamoto H, Yuan L, El-Khoueiry A, Stiles BL.   +23 more
europepmc   +1 more source