Results 101 to 110 of about 13,213,530 (364)
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Development of Paku Hata Craft Products in Citumang, West Java [PDF]
, 2019 Lygodium flexuosum (L.) Sw. (Schizaeaceae) or paku hata is grown in West Java, especially in Citumang, Pangandaran Regency. The local community of Citumang use paku hata as the main materials to produce crafts such as bracelet, hat, bag, wall hanging ...
Ciptandi, F. (Fajar ) +1 more
core
SAM-Dependent Enzyme-Catalysed Pericyclic Reactions in Natural Product Biosynthesis
Nature, 2017 Pericyclic reactions—which proceed in a concerted fashion through a cyclic transition state—are among the most powerful synthetic transformations used to make multiple regioselective and stereoselective carbon–carbon bonds.
M. Ohashi +11 more
semanticscholar +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
On the automorphisms of a graph product of abelian groups
, 2007 We study the automorphisms of a graph product of finitely-generated abelian groups W. More precisely, we study a natural subgroup Aut* W of Aut W, with Aut* W = Aut W whenever vertex groups are finite and in a number of other cases.
Gutierrez, Mauricio +2 more
core +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
The Utilization of Waste Shallot Skin (Allium Cepa L) as Natural Dyeing Material for Textile Product [PDF]
, 2019 Previous studies on the onion skin as a natural dye by Made Diah Angendari showing the colour of each mordant used a Jumputan and suggested using a different concentration of mordant in the next research.
Hendrawan, A. (Aldi ) +1 more
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Applied Biological ChemistryLong-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), especially indomethacin, has severe adverse effects on the gastrointestinal system. Schisandra chinensis (Turcz.) Baill., an herbal medicine used to treat several gastrointestinal diseases ...
Son Hung Tran +10 more
doaj +1 more source