Results 141 to 150 of about 8,248,717 (265)

Natural product peptidomimetics

, 1997
Natural product ...
Philip Evan Thompson (10794765), Colin Barrow (13063191)   +1 more
core  

Product feature extraction using natural language processing techniques [PDF]

, 2012
Nowadays many customers use online services for buying their desired products and many products and services are sold through the Web. On the one hand, considerable numbers of people are expressing their opinion about a particular product or service by ...
Ibrahim, Roliana, Ghorashi, Seyed Hamid, Dastjerdi, Niloufar Salehi   +2 more
core  

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Editorial

Natural Product Communications, 2019
Pawan K. Agrawal
doaj   +2 more sources

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

A Natural Rubber–Based Adhesive Dressing Enriched With Rhodomyrtus tomentosa Leaf Extract Exhibiting Antioxidant, Anti-Inflammatory, and Antibacterial Activities Against Acne-Causing Bacteria

Advances in Pharmacological and Pharmaceutical Sciences
An acne treatment patch was developed by incorporating Rhodomyrtus tomentosa (RT) leaf extract into hyaluronic acid serum, followed by integration with high-quality block natural rubber using a two-roll milling process. RT hyaluronic acid serum exhibited
Apisit Chompraman, Sakkarin Lethongkam, Siwaporn Bilhman, Mareena Daus, Supayang Piyawan Voravuthikunchai, Supakit Paosen   +5 more
doaj   +1 more source

Empowering natural product science with AI: leveraging multimodal data and knowledge graphs

Artificial intelligence (AI) is accelerating how we conduct science, from folding proteins with AlphaFold and summarizing literature findings with large language models, to annotating genomes and prioritizing newly generated molecules for screening using
Mejri, Yassine M, Skiredj, Adam, Medema, Marnix H, Öztürk, Meltem, van der Hooft, Justin JJ, Beniddir, Mehdi A, Coley, Connor W, Meijer, David, van der Hooft, Justin, J J, van der Hooft, Justin J. J., Coley, Connor W., Medema, Marnix, H, Coley, Connor, W, Beniddir, Mehdi, A, Beniddir, Mehdi A., Mejri, Yassine, M, Mejri, Yassine M., Medema, Marnix H.   +17 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source