Results 131 to 140 of about 8,248,717 (265)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Lanostane-type triterpenoids from ganoderma lucidum and G. multipileum fruiting bodies

, 2018
Sixteen lanostane-type triterpeneoids were isolated from the fruiting bodies of wild Ganoderma lucidum and G. multipileum. The new structures 3S,24S,25,26-tetrahydroxy-5α-lanost-8-en-11-one (1) and ganodermanondiol 24,25-acetonide (10) were elucidated by
Thao N.P., Nguyen N.P.D., Luyen N.T., Dat N.T., Dang N.H., Binh P.T., Hiep N.T., Binh P.T.X., Trang D.T., Tri T.M.   +9 more
core   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Tryptophan-driven metabolomic shift in Acidobacteriaceae reveals phytohormones and antifungal metabolites

mSystems
Acidobacteriota is one of the most abundant phyla in soils and has recently attracted attention for its potential role in promoting phytosanitary benefits.
Celine M. Zumkeller, Christoph Hartwig, Walter Lanzalonga, Maria A. Patras, Yang Liu, Michael Marner, Sanja Mihajlovic, Marius S. Spohn, Till F. Schäberle   +8 more
doaj   +1 more source

Natural-Product-Tailored Polyurethane: Size-Dictated Construction of Polypseudorotaxanes with Cyclodextrin–Triterpenoid Pairs

, 2018
Cyclodextrin (CD)-based polyrotaxanes (PRs) and polypseudorotaxanes (PPRs) have attracted considerable attention due to their unique topological structures and functions. However, limited by the simple chemical structures and the single functionalization
Chihui Zheng, Jun Hu, Jie Hao, Jinguo Liu, Jie Hao (665956), Yuxia Gao, Yuxia Gao (364009), Jinguo Liu (695974), Jun Hu (5721), Yong Ju, Chihui Zheng (5724242), Yong Ju (1404961)   +11 more
core   +1 more source

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Artemisitene triggers calcium-dependent ferroptosis by disrupting the LSH-EWSR1 interaction in colorectal cancer

Redox Biology
Colorectal cancer (CRC), propelled by extreme molecular heterogeneity and intractable drug resistance, is rapidly becoming a global health challenge.
Ling Zhu, Qimei Tan, Yuxia Wang, Lihong Hong, Chen Chen, Lingyi Kong, Jianguang Luo   +6 more
doaj   +1 more source

De novo synthesis of short‐chain aldehydes and hydrocarbons secreted by the brown marmorated stink bug Halyomorpha halys

FEBS Open Bio, EarlyView.
The brown marmorated stink bug, Halyomorpha halys, mainly secretes 4‐oxo‐(E)‐2‐hexenal, (E)‐2‐decenal, dodecane and tridecane, a mixture representative of that released by many heteropterans. We demonstrated that H. halys can synthesise these secretory components de novo using dietary glucose.
Haruna Fujimori, Koji Noge
wiley   +1 more source

Bridging the gap: A strategic review of natural product databases and the proposal for the Libyan Natural Products Database

Natural products are a vital source of therapeutic agents due to their diverse chemical structures and wide range of biological activities. With the advancement of computational technologies, natural product databases have become essential tools in drug ...
Abdelkarim N. Sasi
core   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source