Results 51 to 60 of about 13,213,530 (364)

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

Discovery of 15-deoxynaphthomycins activating the antioxidant NRF2-ARE pathway from Streptomyces sp. N50 via genome mining, global regulator introduction, and molecular networking

Microbial Cell Factories
Genome mining is a promising avenue for expanding the repertoire of microbial natural products, which are important for drug development. This approach involves predicting genetically encoded small molecules by examining bacterial genomes via accumulated
Min-Seon Kim, Baskar Selvaraj, Hee-Tae Yeo, Jun-Su Park, Jae Wook Lee, Jin-Soo Park   +5 more
doaj   +1 more source

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

Frontiers in Microbiology, 2015
Microorganisms form diverse multispecies communities in various ecosystems. The high abundance of fungal and bacterial species in these consortia results in specific communication between the microorganisms.
Tina eNetzker, Tina eNetzker, Juliane eFischer, Juliane eFischer, Jakob eWeber, Jakob eWeber, Derek J Mattern, Derek J Mattern, Claudia C König, Claudia C König, Vito eValiante, Volker eSchroeckh, Axel A Brakhage, Axel A Brakhage   +13 more
doaj   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Regional comparison study of Epimedium koreanum using UHPLC-QTOF/MS-based metabolomics approach

Applied Biological Chemistry
The untargeted metabolomics-based molecular networking approach combined with multivariate analysis, proves to be an effective strategy for distinguishing raw materials in herbal medicine according to specific criteria.
Alfan Danny Arbianto, Min Kim, Seon Min Oh, Hyun-Jae Jang, Hyung Won Ryu, Jin-Hyub Paik, Sei-Ryang Oh, Jongmin Ahn   +7 more
doaj   +1 more source

Translation to Bundle Operators [PDF]

, 2007
We give explicit formulas for conformally invariant operators with leading term an $m$-th power of Laplacian on the product of spheres with the natural pseudo-Riemannian product metric for all $m$.Comment: This is a contribution to the Proceedings of the
Branson, Thomas P., Hong, Doojin
core   +5 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Enhanced diastereomeric mixture analysis through integration of quantum chemical calculations with spatio-conformational information obtained from ultraselective NMR techniques

Applied Biological Chemistry
Nuclear Magnetic Resonance (NMR) spectroscopy has become indispensable for elucidating molecular structures in pharmaceutical and natural product chemistry, where precise stereochemical configurations critically determine biological activities and ...
Miyeon Bang, Jin Wook Cha
doaj   +1 more source

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

bioRxiv, 2018
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its effects are poorly understood. Here, we used activity-based protein profiling (ABPP)
Jessica N. Spradlin, Xirui Hu, Carl C. Ward, S. Brittain, Michael D. Jones, Lisha Ou, Milton To, A. Proudfoot, E. Ornelas, Mikias Woldegiorgis, James A. Olzmann, D. Bussiere, J. Thomas, John A. Tallarico, J. McKenna, M. Schirle, T. Maimone, Daniel K. Nomura   +17 more
semanticscholar   +1 more source

Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019.

Journal of Natural Products, 2020
This review is an updated and expanded version of the five prior reviews that were published in this journal in 1997, 2003, 2007, 2012, and 2016. For all approved therapeutic agents, the time frame has been extended to cover the almost 39 years from the ...
D. Newman, G. Cragg
semanticscholar   +1 more source