Results 51 to 60 of about 12,812,869 (370)

Harnessing the Anti-Cancer Natural Product Nimbolide for Targeted Protein Degradation

bioRxiv, 2018
Nimbolide, a terpenoid natural product derived from the Neem tree, impairs cancer pathogenicity; however, the direct targets and mechanisms by which nimbolide exerts its effects are poorly understood. Here, we used activity-based protein profiling (ABPP)
Jessica N. Spradlin, Xirui Hu, Carl C. Ward, S. Brittain, Michael D. Jones, Lisha Ou, Milton To, A. Proudfoot, E. Ornelas, Mikias Woldegiorgis, James A. Olzmann, D. Bussiere, J. Thomas, John A. Tallarico, J. McKenna, M. Schirle, T. Maimone, Daniel K. Nomura   +17 more
semanticscholar   +1 more source

Antimicrobial Natural Products

Antibiotics, 2022
Infectious diseases, resulting from microbial pathogens, are one of the major causes of morbidity and mortality worldwide [...]
openaire   +3 more sources

Pseudodifferential extensions and adiabatic deformation of smooth groupoid actions [PDF]

, 2014
The adiabatic groupoid $\mathcal{G}_{ad}$ of a smooth groupoid $\mathcal{G}$ is a deformation relating $\mathcal{G}$ with its algebroid.
Debord, Claire, Skandalis, Georges
core   +1 more source

Scalemic natural products

Natural Product Reports, 2023
In natural products, a low optical purity is not generally associated with a sloppy enzymatic activity, but rather with the co-expression of antipodal enzymes/directing proteins or, alternatively, with erosion by enzymatic or spontaneous reactions.
Mazzotta, Sarah, Rositano, Vincenzo, Senaldi, Luca, Bernardi, Anna, Allegrini, Pietro, Appendino, Giovanni   +5 more
openaire   +2 more sources

Lactic Acid Bacteria Isolates and the Microbiome of Cincalok, Tempoyak, and Mandai: A Traditional Fermented Food from Kalimantan Island, Indonesia

International Journal of Food Science
Indonesia has abundant traditional fermented food with various lactic acid bacteria (LAB), which can be developed into probiotics for pharmaceutical and functional food and feed products.
Retno Murwani, Refa Anggraeni, Gregorius Nico Adi Setiawan, Putri Dyah Astari, Ni Kadek Dita Cahyani, Mada Triandala Sibero, Ambariyanto Ambariyanto   +6 more
doaj   +1 more source

Naturality and Induced Representations [PDF]

, 2000
We show that induction of covariant representations for C*-dynamical systems is natural in the sense that it gives a natural transformation between certain crossed-product functors.
Echterhoff, Siegfried, Kaliszewski, S., Quigg, John, Raeburn, Iain   +3 more
core   +3 more sources

Natural products in cosmetics

Natural Products and Bioprospecting, 2022
AbstractThe global cosmetics market reached US$500 billion in 2017 and is expected to exceed US$800 billion by 2023, at around a 7% annual growth rate. The cosmetics industry is emerging as one of the fastest-growing industries of the past decade. Data shows that the Chinese cosmetics market was US$60 billion in 2021.
openaire   +3 more sources

The unpredictably eruptive dynamics of spruce budworm populations in eastern Canada

Population Ecology, EarlyView.
We examine historical population data for spruce budworm from several locations through the period 1930–1997, and use density‐dependent recruitment curves to test whether the pattern of population growth over time is more consistent with Royama's (1984; Ecological Monographs 54:429–462) linear R(t) model of harmonic oscillation at Green River New ...
Barry J. Cooke, Jacques Régnière
wiley   +1 more source

Discovery of 15-deoxynaphthomycins activating the antioxidant NRF2-ARE pathway from Streptomyces sp. N50 via genome mining, global regulator introduction, and molecular networking

Microbial Cell Factories
Genome mining is a promising avenue for expanding the repertoire of microbial natural products, which are important for drug development. This approach involves predicting genetically encoded small molecules by examining bacterial genomes via accumulated
Min-Seon Kim, Baskar Selvaraj, Hee-Tae Yeo, Jun-Su Park, Jae Wook Lee, Jin-Soo Park   +5 more
doaj   +1 more source

Microbial communication leading to the activation of silent fungal secondary metabolite gene clusters

Frontiers in Microbiology, 2015
Microorganisms form diverse multispecies communities in various ecosystems. The high abundance of fungal and bacterial species in these consortia results in specific communication between the microorganisms.
Tina eNetzker, Tina eNetzker, Juliane eFischer, Juliane eFischer, Jakob eWeber, Jakob eWeber, Derek J Mattern, Derek J Mattern, Claudia C König, Claudia C König, Vito eValiante, Volker eSchroeckh, Axel A Brakhage, Axel A Brakhage   +13 more
doaj   +1 more source