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The dual nature of TDC – bridging dendritic and T cells in immunity
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley +1 more source
On the Hochschild homology of open Frobenius algebras [PDF]
We prove that the shifted Hochschild chain complex $C\_*(A,A)[m]$ of a symmetric open Frobenius algebra $A$ of degree $m$ has a natural homotopy coBV-algebra structure.
Abbaspour, Hossein
core +2 more sources
Data-based reconstruction of gene regulatory networks of fungal pathogens
In the emerging field of systems biology of fungal infection, one of the central roles belongs to the modelling of gene regulatory networks (GRNs). Utilising omics-data, GRNs can be predicted by mathematical modelling. Here, we review current advances of
Reinhard eGuthke+8 more
doaj +1 more source
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali+3 more
wiley +1 more source
Using Textual Summaries to Describe a Set of Products [PDF]
When customers are faced with the task of making a purchase in an unfamiliar product domain, it might be useful to provide them with an overview of the product set to help them understand what they can expect.
Kuptavanich, Kittipitch
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Aspergillus fumigatus is the most important air-borne fungal pathogen of humans. The interaction of the pathogen with the host’s immune system represents a key process to understand pathogenicity.
Andreas eThywißen+9 more
doaj +1 more source
Protective effect of Tisochrysis lutea on dry eye syndrome via NF-κB inhibition
Dry eye syndrome (DES) affects the cornea, causes pain and hypersensitivity to light. Although inflammation and endoplasmic reticulum stress are known to be involved, the detailed mechanisms remain unknown.
Sung-Chul Hong+6 more
doaj +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
The aim of the study was to identify the cholesterol-lowering activity of indigenous lactic acid bacteria isolated from the small intestine, cecum, and colon of Indonesian native chickens and evaluated for bile salt hydrolase (BSH) activity in vitro by ...
H. Julendra+5 more
doaj +1 more source