Results 71 to 80 of about 13,213,530 (364)
Resistance-Gene Directed Discovery of a Natural Product Herbicide with a New Mode of Action
Nature, 2018 Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century1–3.
Yan Yan +9 more
semanticscholar +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Frontiers in Microbiology, 2013 The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin.
Thorsten eHeinekamp +6 more
doaj +1 more source
Scale-up of an amoeba-based process for the production of the cannabinoid precursor olivetolic acid
Microbial Cell Factories, 2022 Background The availability of new biological platform organisms to get access to innovative products and processes is fundamental for the progress in biotechnology and bioeconomy.
Johann E. Kufs +5 more
doaj +1 more source
Remodelling of the natural product fumagillol employing a reaction discovery approach [PDF]
, 2011 In the search for new biologically active molecules, diversity-oriented synthetic strategies break through the limitation of traditional library synthesis by sampling new chemical space. Many natural products can be regarded as intriguing starting points
Balthaser, Bradley R. +4 more
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Frontiers in Microbiology, 2016 As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against many fungal pathogens.
Daniela eHellwig +10 more
doaj +1 more source
A mass spectrometry-guided genome mining approach for natural product peptidogenomics. [PDF]
, 2011 Peptide natural products show broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes.
Cimermancic, Peter +8 more
core
Equivariant K-theory, generalized symmetric products, and twisted Heisenberg algebra
, 2002 For a space X acted by a finite group $\G$, the product space $X^n$ affords a natural action of the wreath product $\Gn$. In this paper we study the K-groups $K_{\tG_n}(X^n)$ of $\Gn$-equivariant Clifford supermodules on $X^n$.
Wang, Weiqiang
core +1 more source