Results 81 to 90 of about 12,950,355 (371)

Scale-up of an amoeba-based process for the production of the cannabinoid precursor olivetolic acid

open access: yesMicrobial Cell Factories, 2022
Background The availability of new biological platform organisms to get access to innovative products and processes is fundamental for the progress in biotechnology and bioeconomy.
Johann E. Kufs   +5 more
doaj   +1 more source

PRISM 3: expanded prediction of natural product chemical structures from microbial genomes

open access: yesNucleic Acids Res., 2017
Microbial natural products represent a rich resource of pharmaceutically and industrially important compounds. Genome sequencing has revealed that the majority of natural products remain undiscovered, and computational methods to connect biosynthetic ...
M. Skinnider   +3 more
semanticscholar   +1 more source

Remodelling of the natural product fumagillol employing a reaction discovery approach [PDF]

open access: yes, 2011
In the search for new biologically active molecules, diversity-oriented synthetic strategies break through the limitation of traditional library synthesis by sampling new chemical space. Many natural products can be regarded as intriguing starting points
Balthaser, Bradley R.   +4 more
core   +1 more source

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

open access: yesFEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Aspergillus fumigatus melanins: Interference with the host endocytosis pathway and impact on virulence

open access: yesFrontiers in Microbiology, 2013
The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin.
Thorsten eHeinekamp   +6 more
doaj   +1 more source

Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects

open access: yesFrontiers in Pharmacology, 2018
Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively ...
Qing-Yu Zhang   +3 more
semanticscholar   +1 more source

When Sheep Shop: Measuring Herding Effects in Product Ratings with Natural Experiments

open access: yes, 2018
As online shopping becomes ever more prevalent, customers rely increasingly on product rating websites for making purchase decisions. The reliability of online ratings, however, is potentially compromised by the so-called herding effect: when rating a ...
Lederrey, Gael, West, Robert
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

Candida albicans induces Metabolic Reprogramming in human NK cells and responds to Perforin with a Zinc Depletion Response

open access: yesFrontiers in Microbiology, 2016
As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against many fungal pathogens.
Daniela eHellwig   +10 more
doaj   +1 more source

On the Hochschild homology of open Frobenius algebras [PDF]

open access: yes, 2015
We prove that the shifted Hochschild chain complex $C\_*(A,A)[m]$ of a symmetric open Frobenius algebra $A$ of degree $m$ has a natural homotopy coBV-algebra structure.
Abbaspour, Hossein
core   +2 more sources

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