Results 81 to 90 of about 12,812,869 (370)
PRISM 3: expanded prediction of natural product chemical structures from microbial genomes
Nucleic Acids Res., 2017 Microbial natural products represent a rich resource of pharmaceutically and industrially important compounds. Genome sequencing has revealed that the majority of natural products remain undiscovered, and computational methods to connect biosynthetic ...
M. Skinnider +3 more
semanticscholar +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Frontiers in Microbiology, 2013 The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin.
Thorsten eHeinekamp +6 more
doaj +1 more source
On the Hochschild homology of open Frobenius algebras [PDF]
, 2015 We prove that the shifted Hochschild chain complex $C\_*(A,A)[m]$ of a symmetric open Frobenius algebra $A$ of degree $m$ has a natural homotopy coBV-algebra structure.
Abbaspour, Hossein
core +2 more sources
Natural Product Interventions for Chemotherapy and Radiotherapy-Induced Side Effects
Frontiers in Pharmacology, 2018 Cancer is the second leading cause of death in the world. Chemotherapy and radiotherapy are the common cancer treatments. However, the development of adverse effects resulting from chemotherapy and radiotherapy hinders the clinical use, and negatively ...
Qing-Yu Zhang +3 more
semanticscholar +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Frontiers in Microbiology, 2016 As part of the innate immune system, natural killer (NK) cells are directly involved in the response to fungal infections. Perforin has been identified as the major effector molecule acting against many fungal pathogens.
Daniela eHellwig +10 more
doaj +1 more source
Equivariant K-theory, generalized symmetric products, and twisted Heisenberg algebra
, 2002 For a space X acted by a finite group $\G$, the product space $X^n$ affords a natural action of the wreath product $\Gn$. In this paper we study the K-groups $K_{\tG_n}(X^n)$ of $\Gn$-equivariant Clifford supermodules on $X^n$.
Wang, Weiqiang
core +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Frontiers in Microbiology, 2011 Aspergillus fumigatus is the most important air-borne fungal pathogen of humans. The interaction of the pathogen with the host’s immune system represents a key process to understand pathogenicity.
Andreas eThywißen +9 more
doaj +1 more source