Results 11 to 20 of about 979,824 (352)

Transcription activator-like effectors from endosymbiotic bacteria control the reproduction of their fungal host

open access: yesmBio, 2023
The phytopathogenic fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) that produces a crucial virulence factor responsible for the characteristic symptoms of rice seedling blight.
Ingrid Richter   +7 more
doaj   +1 more source

A PRELIMINARY QUALITATIVE STUDY OF AN ALKALOID IN THE FRUIT OF TERONG BELANDA (Cyphomandra betacea, Cav)

open access: yesIndonesian Journal of Chemistry, 2010
Preliminary studies on Terong Belanda (C. betacea ) have been carried out in this investigation with an aim to examine the presence of an alkaloid in the fruit of Terong Belanda.
Fredryk Mandey   +2 more
doaj   +1 more source

Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine

open access: yesNature Communications, 2022
The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. Herein, the authors report the NMR solution structures of a bulge-containing KRAS-G4 that bound to two small molecules ...
Kai-Bo Wang   +10 more
doaj   +1 more source

Functionalized Nitroimidazole Scaffold Construction and Their Pharmaceutical Applications: A 1950–2021 Comprehensive Overview

open access: yesPharmaceuticals, 2022
Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Ria Gupta   +5 more
doaj   +1 more source

Development of an open-learning module in natural product chemistry [PDF]

open access: hybrid, 2006
This article describes the author’s personal perspective on the design, production and delivery of an open-learning module in natural product chemistry.
Stephen P. Stanforth
openalex   +3 more sources

Molecular docking studies of Triphala with catalytic portion of HMG-CoA reductase enzyme [PDF]

open access: yesJournal of HerbMed Pharmacology, 2023
Introduction: Triphala, consisting of three fruits, Phyllanthus emblica L. (Phyllanthaceae), Terminalia bellirica (Gaertn.) Roxb. (Combretaceae), and T.
Prasoborn Rinthong   +2 more
doaj   +1 more source

Mining the Metabiome: Identifying Novel Natural Products from Microbial Communities [PDF]

open access: yes, 2014
Microbial-derived natural products provide the foundation for most of the chemotherapeutic arsenal available to contemporary medicine. In the face of a dwindling pipeline of new lead structures identified by traditional culturing techniques and an ...
Brady, Sean F.   +2 more
core   +1 more source

Lemon Juice as a Natural Catalyse for Synthesis of Shiff’s base: A Green Chemistry Approach [PDF]

open access: yes, 2018
The advantages of the use of natural catalysts are eco-friendly, inexpensive, high yields, nonhazardous and short reaction times. The utilization of green chemistry techniques is the elimination of solvents during chemical processes or the replacement of
Alikhani, A. (Azadeh)   +2 more
core   +1 more source

Click-based synthesis and proteomic profiling of lipstatin analogues [PDF]

open access: yes, 2010
Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved
Adam   +38 more
core   +1 more source

Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods [PDF]

open access: yes, 2015
Flow chemistry is widely used nowadays in synthetic chemistry and has increasingly been applied to complex natural product synthesis. However, to date flow chemistry has not found a place in the area of biomimetic synthesis.
Kamptmann, SB, Ley, SV
core   +1 more source

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