Nature Communications, 2022 The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. Herein, the authors report the NMR solution structures of a bulge-containing KRAS-G4 that bound to two small molecules ...
Kai-Bo Wang +10 more
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mBio, 2023 The phytopathogenic fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) that produces a crucial virulence factor responsible for the characteristic symptoms of rice seedling blight.
Ingrid Richter +7 more
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Molecular docking studies of Triphala with catalytic portion of HMG-CoA reductase enzyme [PDF]
Journal of HerbMed Pharmacology, 2023 Introduction: Triphala, consisting of three fruits, Phyllanthus emblica L. (Phyllanthaceae), Terminalia bellirica (Gaertn.) Roxb. (Combretaceae), and T.
Prasoborn Rinthong +2 more
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Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods [PDF]
, 2015 Flow chemistry is widely used nowadays in synthetic chemistry and has increasingly been applied to complex natural product synthesis. However, to date flow chemistry has not found a place in the area of biomimetic synthesis.
Kamptmann, SB, Ley, SV
core +1 more source
Linking a Pharmaceutical Chemistry Workshop to Pharmacy Practice [PDF]
, 2014 This paper describes the design and implementation of a workshop to enhance pharmacy students’ appreciation of the importance of chemistry for pharmacy practice.
Adams, Andrew +5 more
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Linker Flexibility Facilitates Module Exchange in Fungal Hybrid PKS-NRPS Engineering [PDF]
, 2016 Polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) each give rise to a vast array of complex bioactive molecules with further complexity added by the existence of natural PKS-NRPS fusions.
Andersen, Mikael Rørdam +6 more
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Investigating the Initial Steps in the Biosynthesis of Cyanobacterial Sunscreen Scytonemin [PDF]
, 2014 The cyanobacterial natural product scytonemin (1) functions as a sunscreen, absorbing harmful UV-A radiation. Using information from a recently identified gene cluster, we propose a biosynthetic route to this pigment.
Balskus, Emily Patricia +1 more
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Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
Scientific Reports, 2018 Matrine is a traditional Chinese medicine and botanical pesticide with broad biological activities, including pharmacological and agricultural activities.
Xingan Cheng +9 more
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Sonogashira diversification of unprotected halotryptophans, halotryptophan containing tripeptides; and generation of a new to nature bromo-natural product and its diversification in water [PDF]
, 2017 The blending together of synthetic chemistry with natural product biosynthesis represents a potentially powerful approach to synthesis; to enable this, further synthetic tools and methodologies are needed.
Abou Fayad, A +8 more
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Analysis of major carotenoids and fatty acid composition of freshwater microalgae
Heliyon, 2019 Considering the nutraceutical properties, the high commercial value from pigments and essential lipids and the environmental sustainability, the purposes of this study were to assess the major carotenoids and fatty acids composition of nine microalgae ...
Aline Terra Soares +3 more
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