Results 21 to 30 of about 1,046,985 (303)
Furan-site transformations of obacunone as potent insecticidal agents
Heliyon, 2018 Furan ring is a key pharmacophore for insecticidal activity of limoninoids. To develop natural-product-based insecticidal agents, a series of furan-site transformations (2, 3 and 3a–j) of obacunone were synthesized by selective bromination and following ...
Ping Xiang +5 more
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Facilitating biomimetic syntheses of borrerine derived alkaloids by means of flow-chemical methods [PDF]
, 2015 Flow chemistry is widely used nowadays in synthetic chemistry and has increasingly been applied to complex natural product synthesis. However, to date flow chemistry has not found a place in the area of biomimetic synthesis.
Kamptmann, SB, Ley, SV
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Pharmaceuticals, 2022 Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Ria Gupta +5 more
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Nature Communications, 2022 The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. Herein, the authors report the NMR solution structures of a bulge-containing KRAS-G4 that bound to two small molecules ...
Kai-Bo Wang +10 more
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mBio, 2023 The phytopathogenic fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) that produces a crucial virulence factor responsible for the characteristic symptoms of rice seedling blight.
Ingrid Richter +7 more
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Sonogashira diversification of unprotected halotryptophans, halotryptophan containing tripeptides; and generation of a new to nature bromo-natural product and its diversification in water [PDF]
, 2017 The blending together of synthetic chemistry with natural product biosynthesis represents a potentially powerful approach to synthesis; to enable this, further synthetic tools and methodologies are needed.
Abou Fayad, A +8 more
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Natural Products Chemistry [PDF]
Nature, 1964 The Chemistry of Natural Products Special and Introductory Lectures presented at the Second International Symposium on the Chemistry of Natural Products held in Prague, August 27–September 2, 1962. (International Union of Pure and Applied Chemistry, Section of Organic Chemistry, in conjunction with the Czechoslovak Academy of Science and the ...
openaire +1 more source
Linking a Pharmaceutical Chemistry Workshop to Pharmacy Practice [PDF]
, 2014 This paper describes the design and implementation of a workshop to enhance pharmacy students’ appreciation of the importance of chemistry for pharmacy practice.
Adams, Andrew +5 more
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Investigating the Initial Steps in the Biosynthesis of Cyanobacterial Sunscreen Scytonemin [PDF]
, 2014 The cyanobacterial natural product scytonemin (1) functions as a sunscreen, absorbing harmful UV-A radiation. Using information from a recently identified gene cluster, we propose a biosynthetic route to this pigment.
Balskus, Emily Patricia +1 more
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Synthesis, characterization and in vitro biological evaluation of two matrine derivatives
Scientific Reports, 2018 Matrine is a traditional Chinese medicine and botanical pesticide with broad biological activities, including pharmacological and agricultural activities.
Xingan Cheng +9 more
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