Results 41 to 50 of about 1,189,605 (351)

Applications of the Pharmacophore Concept in Natural Product inspired Drug Design

Molecular Informatics, 2020
Pharmacophore‐based techniques are nowadays an important part of many computer‐aided drug design workflows and have been successfully applied for tasks such as virtual screening, lead optimization and de novo design.
T. Seidel, O. Wieder, A. Garon, T. Langer   +3 more
semanticscholar   +1 more source

Xanthine scaffold: scope and potential in drug development

Heliyon, 2018
Medicinal plants have been the basis for discovery of various important marketed drugs. Xanthine is one such lead molecule. Xanthines in various forms (caffeine, theophylline, theobromine, etc) are abode in tea, coffee, cocoa, chocolate etc.
Nivedita Singh, Ashwinee Kumar Shreshtha, M.S. Thakur, Sanjukta Patra   +3 more
doaj   +1 more source

Living GenoChemetics by hyphenating synthetic biology and synthetic chemistry in vivo [PDF]

, 2017
Marrying synthetic biology with synthetic chemistry provides a powerful approach toward natural product diversification, combining the best of both worlds: expediency and synthetic capability of biogenic pathways and chemical diversity enabled by organic
AD Roy, AI Anzellotti, AS Eustáquio, AS Eustáquio, B Gust, B Staubach, C Dong, C Schnepel, C Sánchez, CA Lewis, CD Spicer, CD Spicer, DJ Newman, DRM Smith, EJ Rackham, F Izquierdo, I Maluenda, J Latham, J Yang, JH Li, JM Chalker, JP Gomez-Escribano, KW Anderson, LJ Durak, LK Mohler, MA Carvalho, MA Düfert, MJ Corr, N Li, PA Evans, PA Lichtor, RJM Goss, RM Yusop, T Kinzel, T Willemse, TJ Wadzinski, TP Pathak, TP Pathak, W Runguphan, X Tong, Y Feng, Z Gao   +41 more
core   +2 more sources

Antibiofilm formation activity of lupinifolin isolated from Derris reticulata stems against Enterococcus faecalis [PDF]

Journal of HerbMed Pharmacology
Introduction: The biofilm formation capability of Enterococcus faecalis is one of the key virulence factors contributing to its multidrug resistance and therapeutic challenges.
Pawitra Pulbutr, Kridsanun Seelakot, Nicharee Kumphupong, Sakulrat Rattanakiat   +3 more
doaj   +1 more source

Natural product sciences: an integrative approach to the innovations of plant natural products

Science China Life Sciences, 2020
The study on plant natural products not only helps us understand that their structural diversity is the inevitable result of plant species diversity, but also helps us understand certain rules and unity of the inevitable connection between the two.
Yuemao Shen, X. Hao
semanticscholar   +1 more source

Optimization of choline chloride-glycerol based natural deep eutectic solvent for extraction bioactive substances from Cinnamomum burmannii barks and Caesalpinia sappan heartwoods

Heliyon, 2019
Indonesian cassia (Cinnamomum burmannii Blume) is commonly used as a condiment. It reportedly contains a number of major phytochemical constituents such as trans-cinnamaldehyde and coumarin. Sappan wood (Caesalpinia sappan) is a native plant of Southeast
Aditya Sindu Sakti, Fadlina Chany Saputri, Abdul Mun'im   +2 more
doaj   +1 more source

Canvass: a crowd-sourced, natural-product screening library for exploring biological space [PDF]

, 2018
NCATS thanks Dingyin Tao for assistance with compound characterization. This research was supported by the Intramural Research Program of the National Center for Advancing Translational Sciences, National Institutes of Health (NIH). R.B.A.
Andrade, Rodrigo B., Bougie, Danielle, Boxer, Matthew B., Brimacombe, Kyle R., Brown, Lauren E., Brown, M Kevin, Burns, Noah Z., Cha, Jin K., Cheff, Dorian M., Cheng, Ken, Clardy, Jon, Clement, Jason A., Coussens, Nathan P., Crooks, Peter A., Cuny, Gregory D., Dillon, Christopher, Dorjsuren, Dorjbal, Eastman, Richard T., Ganor, Jake, Garg, Neil K., Goess, Brian C., Grossman, Robert B., Guha, Rajarshi, Hall, Matthew D., Henderson, Mark J., Huang, Ruili, Hughes, Chambers C., Iannotti, Michael J., Inglese, James, Itkin, Zina, Jadhav, Ajit, Johnston, Jeffrey N., Joullie, Madeleine M., Karavadhi, Surendra, Kearney, Sara E., Kinghorn, A. Douglas, Kingston, David G. I., Klumpp-Thomas, Carleen, Krische, Michael J., Kwon, Ohyun, Lee, Tobie D., Lynch, Caitlin, Maimone, Thomas J., Majumdar, Susruta, Maloney, Katherine N., Mevers, Emily E., Michael, Sam, Mohamed, Enas, Moreno, Jesus, Morrill, Lucas A., Murphy, Brian T., Nagorny, Pavel, Olson, David E., Overman, Larry E., Picazo, Elias, Porco, John A., Ren, Tianjing, Rivas, Fatima, Rohde, Jason M., Ross, Samir A., Roth, Jacob S., Sakamuru, Srilatha, Sarpong, Richmond, Sharma, Indrajeet, Shaw, Jared T., Shen, Ben, Shen, Min, Shi, Wei, Shinn, Paul, Simeonov, Anton, Snyder, John K., Stephenson, Corey R. J., Sun, Wei, Susick, Robert B., Tan, Derek S., Tang, Yi, Taylor, Richard E., Thomson, Regan J., Titus, Steven A., Verano, Alyssa L., Vosburg, David A., Wan, Kanny K., Wu, Jimmy, Wuest, William M., Xia, Menghang, Xu, Zhengren, Yasgar, Adam, Zahoranszky-Kohalmi, Gergely, Zakarian, Armen, Zhang, Ya-Qin, Zhang, Yufeng, Zhao, Jinghua, Zhao, Tongan, Zheng, Wei, Zuo, Zhong   +94 more
core   +1 more source

CuAAC click chemistry for the enhanced detection of novel alkyne-based natural product toxins [PDF]

, 2018
In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms.
Field, Robert A., Hems, Edward S., Saalbach, Gerhard, Wagstaff, Ben A.   +3 more
core   +1 more source

The crystal structure of the Matrine derivative: 12-(1H-indol-1-yl)dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one hydrate, C23H29N3O

Zeitschrift für Kristallographie - New Crystal Structures, 2017
C23H29N3O, orthorhombic P212121 (no. 19), a = 8.62130(10) Å, b = 18.25770(10) Å, c = 25.6873(2) Å, V = 4043.31(6) Å3, Z = 8, Rgt(F) = 0.0305, wRref(F2) = 0.0807, T = 293(2) K.
Xing-An Cheng, Zhan-Mei Liu, Wei-Xin Liang, Bo Wu, Xu-Hong Jiang   +4 more
doaj   +1 more source

Using water, light, air and spirulina to access a wide variety of polyoxygenated compounds [PDF]

, 2012
A new set of completely green methods utilising air, light, water and spirulina to transform readily accessible furan substrates into a diverse range of synthetically useful polyoxygenated motifs commonly found in natural products is presented ...
Alexopoulou, Ioanna, Montagnon, Tamsyn, Noutsias, Dimitris, Vassilikogiannakis, Georgios   +3 more
core   +1 more source