Results 71 to 80 of about 1,495,910 (392)

Target Identification and Validation of (+)-2-(1-Hydroxyl-4-Oxocyclohexyl) Ethyl Caffeate, an Anti-Inflammatory Natural Product

European Journal of Inflammation, 2012
(+)-2-(1-hydroxyl-4-oxocyclohexyl) ethyl caffeate (HOEC) was isolated from Incarvillea mairei var. granditlora (Wehrhahn) Grierson. The plants of the Incarvillea genus have long been used as folk medicines for the treatment of inflammation-related ...
L. Li, H-W. Zeng, F. Liu, J-G. Zhang, R-C. Yue, W-Q. Lu, X. Yuan, W-X. Dai, H. Yuan, Q-Y. Sun, J. Huang, H-L. Li, Y-S. Li, L. Shan, W-D. Zhang   +14 more
doaj   +1 more source

Production of hollow-type spherical bacterial cellulose as a controlled release device by newly designed floating cultivation

Heliyon, 2018
We developed a novel cultivating system for hollow-type spherical bacterial cellulose (HSBC) gel production without any molds or template. It consisted of floating aqueous medium droplet containing Gluconacetobacter xylinus (G.
Toru Hoshi, Kazuyoshi Yamazaki, Yuki Sato, Takaya Shida, Takao Aoyagi   +4 more
doaj   +1 more source

Neurotrophic Natural Products: Chemistry and Biology [PDF]

Angewandte Chemie International Edition, 2013
AbstractNeurodegenerative diseases and spinal cord injury affect approximately 50 million people worldwide, bringing the total healthcare cost to over 600 billion dollars per year. Nervous system growth factors, that is, neurotrophins, are a potential solution to these disorders, since they could promote nerve regeneration.
Xu, Jing, Lacoske, Michelle H, Theodorakis, Emmanuel A   +2 more
openaire   +4 more sources

Highlight on the problems generated by p-coumaric acid analysis in fermentations [PDF]

, 2008
p-Coumaric acid is a natural hydroxycinnamic acid existing in grapes and wine. It is the precursor of the 4-ethylphenol molecule through the bioconversion reaction by Brettanomyces yeast. Chromatographic methods are the most common techniques to detect p-
Brandam, Cédric, Lteif, Roger, Medawar, Wissam, Salameh, Dominique, Strehaiano, Pierre   +4 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression

Heliyon, 2019
Plants of the Asteraceae family have been used in traditional medicine for centuries due to their main antimicrobial and analgesic activities. A liniment from Artemisia californica has recently been tested on patients affected by either acute pain or ...
Filomena Perri, Luca Frattaruolo, Ian Haworth, Matteo Brindisi, Asma El-magboub, Angela Ferrario, Charles Gomer, Francesca Aiello, James David Adams   +8 more
doaj   +1 more source

Toxin-Producing Endosymbionts Shield Pathogenic Fungus against Micropredators

mBio, 2022
The fungus Rhizopus microsporus harbors a bacterial endosymbiont (Mycetohabitans rhizoxinica) for the production of the antimitotic toxin rhizoxin.
Ingrid Richter, Silvia Radosa, Zoltán Cseresnyés, Iuliia Ferling, Hannah Büttner, Sarah P. Niehs, Ruman Gerst, Kirstin Scherlach, Marc Thilo Figge, Falk Hillmann, Christian Hertweck   +10 more
doaj   +1 more source

Heterologous expression of bacterial natural product biosynthetic pathways.

Natural product reports (Print), 2019
Covering: 2013 to June 2018Heterologous expression of natural product biosynthetic pathways is of increasing interest in microbial biotechnology, drug discovery and optimization. It empowers not only the robust production of valuable biomolecules in more
Liujie Huo, Joachim J. Hug, Chengzhang Fu, Xiaoying Bian, Youming Zhang, R. Müller   +5 more
semanticscholar   +1 more source

Enzymatic functionalization of carbon-hydrogen bonds [PDF]

, 2011
The development of new catalytic methods to functionalize carbon–hydrogen (C–H) bonds continues to progress at a rapid pace due to the significant economic and environmental benefits of these transformations over traditional synthetic methods.
Arnold, Frances H., Coelho, Pedro S., Lewis, Jared C.   +2 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source