Results 71 to 80 of about 979,824 (352)
An update on cyclohepta[b]indoles [PDF]
, 2021 The cyclohepta[b]indole scaffold constitutes a salient structural motif in natural products as well as in men-made pharmaceutically active ingredients. Cyclohepta[b]indoles consist of an indole nucleus fused to a seven-membered carbacycle.
Benedix, Lars +2 more
core
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
Synthetic Studies in Natural Product Chemistry [PDF]
, 1960 I. A stereospecific total synthesis of D-(-)-shikimic acid: The evidence which led to assignment of the structure and absolute stereochemistry of shikimic acid is reviewed.
McCrindle, Robert
core
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Analysis of major carotenoids and fatty acid composition of freshwater microalgae
Heliyon, 2019 Considering the nutraceutical properties, the high commercial value from pigments and essential lipids and the environmental sustainability, the purposes of this study were to assess the major carotenoids and fatty acids composition of nine microalgae ...
Aline Terra Soares +3 more
doaj
Heliyon, 2017 To treat Alzheimer's disease (AD), the available candidates are effective only against mild AD or have side effects. So, a study was planned to synthesis new candidates that may have good potential to treat AD.
Mehreen Lateef +10 more
doaj +1 more source
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
The effect of mixing and consistency on cellulose cationization
Heliyon, 2019 Traditional chemical modifications of cellulose are usually done at low or medium consistencies. Processing at high solids content is expected to provide a leap forward in reduction of manufacturing costs such as minimization of chemical use, energy ...
Pia Willberg-Keyriläinen +4 more
doaj
Journal of Chemistry, 2015 Stem barks derived from twenty-one medicinal plants were extracted in methanol (100%) and acetone-water (70 : 30 v/v) and at room as well as at reflux temperature conditions.
Muhammad Asam Raza +2 more
doaj +1 more source
Karmitoxin: An amine containing polyhydroxy-polyene toxin from the marine dinoflagellate Karlodinium armiger [PDF]
, 2017 Marine algae from the genus Karlodinium are known to be involved in fish-killing events worldwide. Here we report for the first time the chemistry and bioactivity of a natural product from the newly described mixotrophic dinoflagellate Karlodinium ...
Rasmussen, Silas Anselm +9 more
core +3 more sources