Results 111 to 120 of about 18,110,415 (308)

Anti-Alzheimer’s Natural Products Derived from Plant Endophytic Fungi

, 2023
Alzheimer’s is the most common cause of dementia worldwide and seriously affects patients’ daily tasks. Plant endophytic fungi are known for providing novel and unique secondary metabolites with diverse activities.
Li Liu, Juntai Zhu, Zimo Wang, Wanxin Fu, Lixia Song   +4 more
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Determining the structures of halogenated marine natural products by total synthesis [PDF]

, 2011
Elatenyne, a brominated C15 acetogenin isolated from the red Laurencia elata marine algae, was originally assigned a pyranopyran structure. Previous total synthesis of the pyranopyran structure has found this assignment to be incorrect.
Burton, Jonathan W., Dyson, Bryony Sara, Dyson, Bryony S   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Review on natural products databases: where to find data in 2020

Journal of Cheminformatics, 2020
Natural products (NPs) have been the centre of attention of the scientific community in the last decencies and the interest around them continues to grow incessantly.
Maria Sorokina, C. Steinbeck
semanticscholar   +1 more source

Mining Microbial Communities: Exploring Symbiotic Bacteria as a Source of New Natural Products [PDF]

, 2013
As ubiquitous inhabitants of Earth, bacteria represent a diverse resource in the search for new natural products. In order for the field of natural products to progress, new and exciting sources of biodiversity must be continually accessed.
Theodore, Christine M.
core  

Targeted Dereplication of Microbial Natural Products by High-Resolution MS and Predicted LC Retention Time [PDF]

, 2017
A new strategy for the identification of known compounds in Streptomyces extracts that can be applied in the discovery of natural products is presented.
Ming Him Tong, Yu, Yi, Jeanette Hammer Andersen, Kwaku Kyeremeh, Gabriela Cimpan, Ebel, Rainer, Marc Stierhof, Deng, Hai, Albert Van Wyk, Chervin, Justine, Kine Østnes Hansen, Marcel Jaspars, Andersen, Jeanette Hammer, Tabudravu, Jioji N., Wyk, Albert Van, Doe Peace, Hansen, Kine Østnes, Rainer Ebel, Hai Deng, Kyeremeh, Kwaku, Veronica Paget, Cimpan, Gabriela, Jioji N. Tabudravu, Tabudravu, Jioji, Paget, Veronica, Dagmar Solveig Urgast, Stierhof, Marc, Urgast, Dagmar Solveig, Justine Chervin, Yi Yu, Peace, Doe, Tong, Ming Him, Jaspars, Marcel   +32 more
core   +1 more source

Mitigation of Insulin Resistance by Natural Products from a New Class of Molecules, Membrane-Active Immunomodulators

, 2023
Insulin resistance (IR), accompanied by an impaired cellular glucose uptake, characterizes diverse pathologies that include, but are not limited to, metabolic disease, prediabetes and type 2 diabetes.
Elzbieta Izbicka, Robert T. Streeper
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Bio-Functional Natural Products in Edible Resources for Human Health and Beauty

, 2022
Natural products remain important repositories of promising therapeutic candidates due to their rich chemical and biological diversity [...
Morikawa, Toshio, Toshio Morikawa
core   +1 more source