Results 51 to 60 of about 18,110,415 (308)
Spirocyclic Motifs in Natural Products
, 2019 Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no attempt to analyze the structural diversity of various spirocyclic motifs occurring in natural ...
Olga Babich +4 more
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Editorial to special issue: anti-inflammatory activity of natural products [PDF]
, 2020 Inflammation involves several steps to respond to harmful stimuli. Plants, plant products, marine compounds, mushrooms and bee products (honey, propolis, bee pollen) have been a target of study in order to find effective anti-inflammatory compounds of ...
Miguel, Maria, Maria Graça Miguel
core +1 more source
Plant-Derived Natural Products: A Source for Drug Discovery and Development
Drugs and Drug CandidatesFor thousands of years, nature has been a source of medical substances, and an astounding numeral of contemporary remedies have been identified from natural origins.
N. Chaachouay, L. Zidane
semanticscholar +1 more source
Natural Products from the Marine Sponge Subgenus Reniera
, 2021 Marine sponges are one of the prolific producers of bioactive natural products with therapeutic potential. As an important subgenus of Haliclona, Reniera sponges are mainly distributed in the Mediterranean Sea and Atlantic area, and had been chemically ...
Xuelian Bai +3 more
core +1 more source
The Scientific World JournalThe protein–ligand complexes with the best binding energy were subjected to 100-ns molecular dynamics simulations to evaluate the stability of the complexes as a function of time, and the binding free energies were calculated for each complex.
Víctor Eljach-Cordoba +4 more
doaj +1 more source
Strep-tag® II for One-Step Affinity Purification of Active bHLHzip Domain of Human c-Myc
BioTechniques, 1999 The c-Myc protein, the product of the cmyc protooncogene, is a nuclear phosphoprotein with DNA-binding properties when heterodimerized with the Max protein.
N. Zwicker +4 more
doaj +1 more source
BiomedicinesGlobally, malignancies cause one out of six mortalities, which is a serious health problem. Cancer therapy has always been challenging, apart from major advances in immunotherapies, stem cell transplantation, targeted therapies, hormonal therapies ...
Pritee Chunarkar-Patil +9 more
semanticscholar +1 more source
Natural Products as Modulators of Sirtuins.
, 2020 Natural products have been used for the treatment of human diseases since ancient history. Over time, due to the lack of precise tools and techniques for the separation, purification, and structural elucidation of active constituents in natural resources
Fidele Ntie-Kang +5 more
core +1 more source
Recent Advances of Marine Natural Indole Products in Chemical and Biological Aspects
, 2023 The ocean has always been one of the important sources of natural products. In recent years, many natural products with different structures and biological activities have been obtained, and their value has been clearly recognized.
Kangping Sun, Jingyong Sun, Haoyi Sun
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source