Results 71 to 80 of about 8,670,110 (314)

Natural Products as Drug Candidates for Redox-Related Human Disease

, 2023
This Special Issue presented recent progress on natural products that serve as drug candidates for redox-related human diseases [...
Kirkwood M. Land, Canhua Huang, Jong H. Kim, Yuan-Yuan Zhang, Huang, Canhua, Land, Kirkwood M., Zhang, Yuan-Yuan, Kim, Jong H.   +7 more
core   +1 more source

InertDB as a generative AI-expanded resource of biologically inactive small molecules from PubChem

Journal of Cheminformatics
The development of robust artificial intelligence (AI)-driven predictive models relies on high-quality, diverse chemical datasets. However, the scarcity of negative data and a publication bias toward positive results often hinder accurate biological ...
Seungchan An, Yeonjin Lee, Junpyo Gong, Seokyoung Hwang, In Guk Park, Jayhyun Cho, Min Ju Lee, Minkyu Kim, Yun Pyo Kang, Minsoo Noh   +9 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Biological Activities of Natural Products

, 2020
Natural products and their biological activities are currently a subject of great interest in the pharmaceutical, health food, and cosmetics industries, and numbers of scientific studies in this field are increasing rapidly [...
Agnieszka Szopa, Halina Maria Ekiert
core   +1 more source

Mitigation of Insulin Resistance by Natural Products from a New Class of Molecules, Membrane-Active Immunomodulators

, 2023
Insulin resistance (IR), accompanied by an impaired cellular glucose uptake, characterizes diverse pathologies that include, but are not limited to, metabolic disease, prediabetes and type 2 diabetes.
Elzbieta Izbicka, Robert T. Streeper
core   +1 more source

1H NMR-Based Metabolomic Profiling and Chemometric Discrimination of Brazilian Olive Oils From Rio Grande do Sul: First Characterization of a New Extra Virgin Olive Oil Frontier

Journal of Food Quality
Extra virgin olive oil (EVOO) is a high-value product whose quality is closely linked to composition, making it vulnerable to fraud and mislabeling. Rapid, nondestructive tools are therefore needed to support authenticity assessment.
Ana Júlia Gomes Donada, Estela Zanotti, Rafael Freitas Corá, Luana C. Crocoli, Paulo G. Celso, Raul A. Sperotto, Sidnei Moura   +6 more
doaj   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

A functional proteomic-based platform to disclose natural products cellular targets, Repositioning Natural Products in Drug Discovery

, 2020
A functional proteomic-based platform to disclose natural products cellular ...
Maria Chiara Monti
core  

Natural bee products and their apitherapeutic applications

, 2020
The honey bee has been of enormous importance to humanity for thousands of years. Many different bee products used for traditional and complementary therapies, also known as apitherapy, are currently available.
Kolayli, Sevgi, Merve Keskin, Keskin, Merve, Sevgi Kolayli   +3 more
core   +1 more source

A Tandem Cyclization-Ugi Sequence of Reactions for the Synthesis of 1,4-Benzoxazine-3-carboxamide Derivatives

Heteroatom Chemistry
Benzo[b][1,4]oxazines constitute an important scaffold in synthetic organic chemistry in terms of having special applications in drug discovery and bioactive compounds. Thus, finding new methods for their synthesis is of high importance.
Ali Sharifi, Marzieh Sharifi, M. Saeed Abaee, Mojtaba Mirzaei   +3 more
doaj   +1 more source