Results 71 to 80 of about 18,110,415 (308)
The Natural Products Atlas 3.0: extending the database of microbially derived natural products
Nucleic Acids ResearchThe Natural Products Atlas is a database of microbially derived natural products that contains structures, producing organism taxonomy, biosynthetic and chemical ontology classifications, grouping by compound classes and cross-links to a suite of other ...
Ella F. Poynton +9 more
semanticscholar +1 more source
Neuroprotective Natural Products for Alzheimer’s Disease
Cells, 2021 Alzheimer’s disease (AD) is the number one neurovegetative disease, but its treatment options are relatively few and ineffective. In efforts to discover new strategies for AD therapy, natural products have aroused interest in the research community and ...
Xin Chen, J. Drew, Wren Berney, Wei Lei
semanticscholar +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Food & Medicine HomologyArtemisia argyi polysaccharide (AAP) is an important active component extracted from the leaves of A. argyi. Currently, the effects of AAP in mouse model of intestinal inflammation are unclear.
Er-Juan Ning +10 more
doaj +1 more source
Natural products as sources of new drugs over the last 25 years.
Journal of Natural Products, 2007 This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003. In the case of all approved agents the time frame has been extended to include the 251/2 years from 01/1981 to 06/2006 for all ...
D. Newman, G. Cragg
semanticscholar +1 more source
Targeting Drug Chemo-Resistance in Cancer Using Natural Products
Biomedicines, 2021 Cancer is one of the leading causes of death globally. The development of drug resistance is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms to reduce the therapeutic effects of anticancer drugs, thereby causing
Wamidh H. Talib +4 more
semanticscholar +1 more source
A Chemometric Analysis of Deep-Sea Natural Products
, 2019 Deep-sea natural products have been created by unique marine organisms that thrive in a challenging environment of extreme conditions for its inhabitants.
Lisa I. Pilkington
core +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Natural Product Communications, 2022 In the current study, the ethanol extract of Premna flavescens leaves (EPF) was evaluated for its in vivo antiinflammatory, analgesic potentials, and acute oral toxicity. The analgesic potential was assessed through the acetic acid-induced writhing test,
Ha Minh Le +3 more
doaj +1 more source
Phytomedicine Plus, 2021 Background: Dyslipidemia a common pathology in metabolic syndrome results due to various factors. Although statins are proven for its beneficial role in the management of hyperlipidemia, plant-based foods and their ingredients are still a cornerstone of ...
Malarvizhi R +5 more
doaj +1 more source