Results 81 to 90 of about 1,260,577 (268)

Facilitators and Barriers to Implementation of WHO HEARTS Strategy for Hypertension and Diabetes Among People Living with HIV in Eastern Uganda: A COM-B Analysis

HIV/AIDS: Research and Palliative Care
Richard Katuramu,1,2 Yueyun Li,3 Maureen Namugaya,4 Steven Nsereko Muwanga,4 Ronald Kibuuka,4 Francis Mawejje,4 Samuel Baker Obakiro,4,5 Andrew Marvin Kanyike,4,6 Zhihui Li31Department of Internal Medicine, Faculty of Health Sciences, Busitema University,
Katuramu R, Li Y, Namugaya M, Muwanga SN, Kibuuka R, Mawejje F, Obakiro SB, Kanyike AM, Li Z   +8 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

TAT as a new marker and its use for noninvasive chemical biopsy in NASH diagnosis

Molecular Medicine
Background Early diagnosis of Nonalcoholic steatohepatitis (NASH) is crucial to prevent its progression to hepatocellular carcinoma, but its gold standard diagnosis still requires invasive biopsy.
Sihyang Jo, Jin-Mo Kim, Minshu Li, Han Sun Kim, Yong Jin An, Sunghyouk Park   +5 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Epigenetically-controlled CEBPB regulates kidney cancer tumorigenesis via GPD1L-mediated ether lipid synthesis

Cell Death and Disease
Clear cell renal cell carcinoma (ccRCC) is characterized by disrupted lipid metabolism, traditionally attributed to VHL mutations and HIF stabilization.
Thi Ha Nguyen, Xuan Linh Mai, Tin Tin Manh Nguyen, Hoonsik Nam, Sunghyouk Park, Ji Yun Lee   +5 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases

Experimental and Molecular Medicine
The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD+-linked glycerol 3-phosphate dehydrogenase 1 (GPD1) and mitochondrial FAD-linked glycerol 3-phosphate dehydrogenase 2 (GPD2).
Sehyun Oh, Xuan Linh Mai, Jiwoo Kim, Arvie Camille V. de Guzman, Ji Yun Lee, Sunghyouk Park   +5 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Preparation, Characterization, and In Vitro Bioactivity of Artemisia capillaris Thunb. Leaf Protein Peptide Selenium Chelates

International Journal of Food Science
This study aimed to prepare Artemisia capillaris Thunb. leaf protein peptide selenium chelates (AP-Se) employing sodium selenite as a selenium (Se) source, with a focus on their structure and biological activities. Artemisia capillaris Thunb.
Wen-Lu Wei, Wen-Jun Wang, Chuan-Long Yu, Hui Chen, Su-Yun Lin, Ling-Li Chen   +5 more
doaj   +1 more source

Metabolite Profiling and Anti-Inflammatory Activities of Fritillaria cirrhosa D. Don Bulbs Derived from Tissue Culture

Molecules
Fritillaria cirrhosa D. Don (known as Chuan-Bei-Mu in Chinese) is a prominent medicinal plant utilized in traditional medicine for chronic respiratory ailments.
Yu Wang, Jiamin Liu, Enhao Zhang, Yixi Yang, Qiuxia Lu, Ziwei Zhu, Rui Li   +6 more
doaj   +1 more source